酪氨酸

On the basis of the instrumentation to study intact-receptor based on maxillary palp of cockroach Periplaneta Americana, a thermoplate was designed for constant temperature control during the experiment and a new electrode holder was also designed for improving reproducibility.

依响应频率将氨基酸分成了三类：响应频率最高的第一类为天冬氨酸、谷氨酸、甘氨酸和脯氨酸，其次为第二类包括组氨酸、精氨酸和苯丙氨酸，第三类为没有响应信号的包括丙氨酸、色氨酸、酪氨酸和苏氨酸等。

Results\ The levels of some essential amino acids like valine,leucine and histidine were significantly lower than those of normal controls.

结果 血透患者在透析前的必需氨基酸除苯丙氨酸外均较正常对照组降低，其中以缬氨酸、亮氨酸和组氨酸下降为显著；非必需氨基酸中精氨酸、甘氨酸和鸟氨酸明显升高；酪氨酸/苯丙氨酸和丝氨酸/甘氨酸的比值较对照组明显降低。

In these reactions the alkyl and alkyloxy groups in the 4-positions are displaced by the arylamino-group. Since the enzyme tyrosinase exits in melanoma cells and it is uniquely associated with melanocytes, which suggested a highly focused drug delivery system.

基于该反应机理，设计了酪氨酸酶的三个前药模型化合物并进行了体外模型实验，即以酪氨酸酶的底物苯酚和邻氨基苯酚作为药物布洛芬和5—氟脲嘧啶的载体，经酪氨酸酶和亲核试剂的作用，实现药物的释放。

The cancers studied here were throat cancer, aute non- lymphoblas He leukem ia and acut lymphoblastic leukemia. The result s indicated that,(1)the levels of Leu, Lys, Ser Asn,Ile,Gly,and Thr were obviously decreased whea lse the levels of orn, Trp evidently increased in cultural liquid of throat can cer cell line indicating that the growth of HepⅡ cell consumed 7 amino acids and releaced 2 amino acids into cultural liquid.(2)the levels of Glu, Gls, Leu, Phe, Tyr and Trp were evidently increased while the levels of Thr , His, Ala decreased in plasma from patient with ANLL. These r esults were consistent with the previous report.(3)the levels of Gly, Trp and Phe in plasma from patients with ANLL evidently de creased and the levels of Ala, His increased after therapy indicating that cance r cells were growing in an anaerobic catabolism state.

这些癌肿包括喉癌HepⅡ细胞，急性非淋巴细胞白血病和急性淋巴细胞白血病，结果表明：(1)喉癌细胞株培养过程中亮氨酸、赖氨酸、丝氨酸、天冬酰胺、异亮氨酸、甘氨酸以及苏氨酸等水平明显降低，而色氨酸水平明显增加，说明喉癌细胞的生长繁殖必须依赖以上7种氨基酸同时释放了色氨酸；(2)急性非淋巴细胞白血病患者血浆中的谷氨酸、甘氨酸、亮氨酸、苯丙氨酸、酪氨酸和色氨酸等水平明显升高，而苏氨酸、组氨酸、丙氨酸等水平明显降低，这些结果与国际报道相一致；(3)经治疗后，ANLL患者血浆中甘氨酸、色氨酸和苯丙氨酸等水平明显降低，而丙氨酸、组氨酸等水平明显升高，表明肿瘤细胞处在无氧代谢。

Specificity studies on the substrate revealed that the HdPO was capable of oxidizing not only the o-diphenol, but also tyrosine. The apparent Km value on tyrosine was about 9.52 mmol/L. As shown in the experiments, HdPO behaved oxidizing activities both on diphenol and monophenol, which implies that the HdPO was probably not only a type of tyrosinase-type PO but also a catechol-type.

底物特异性研究还发现此HdPO不仅对邻苯二酚具有氧化活性，对酪氨酸底物也具有氧化活性，且对酪氨酸的Km值约为9.52mmol/L，说明该酶既具有酪氨酸酶活性，又具有儿茶酚酶活性。

Xinjiang medicine's content of amino acid of fruit juice of mulberry fruit is concrete: 2,6-diaminocaproic acid 0.089, serine 0.044, histidine 0.025, glycine 0.049, ammonia 0.088, valine 0.057, 2-amino-5-guanidinovaleric acid 0.051, isoleucine 0.042, Radix Asparagi 0.068, 0.020, threonine 0.076, 0.022, 0.128, 0.069, third 0.048, benzene third 0.042 leucine glutaminic acid methionine hydroxyphenylaminopropionic acid.

新疆药桑椹果汁氨基酸含量具体为：赖氨酸0.089、丝氨酸0.044、组氨酸0.025、甘氨酸0.049、氨0.088、缬氨酸0.057、精氨酸0.051、异亮氨酸0.042、天门冬氨酸0.068、酪氨酸0.020、苏氨酸0.076、蛋氨酸0.022 、谷氨酸0.128、亮氨酸0.069、丙氨酸0.048、苯丙氨酸0.042。

The thermal decomposition of tyrosine was studied by the methods of DTA and TG. The molecular geometries of tyrosine, intermediates and the products were optimized by AM1 method. The thermolytic mechanism is put forward through the results of the experiment and the calculation.

用差热曲线、热重曲线法测得了酪氨酸的热解曲线，用AM1方法优化了酪氨酸及其中间产物和产物分子的构型，计算了有关分子的键长和键级，通过对其热解过程的分析及AM1研究的结果，首次提出了酪氨酸的热解机理。

Vernonia anthelmintica can significantly enhance the activity of tyrosinase in vitro and proliferation of B-16 murine melanoma cell.

结果驱虫斑鸠菊体外可激活酪氨酸酶活性，增强B - 16鼠黑素瘤细胞增殖，提高酪氨酸酶和黑色素合成能力；对整体动物黑素细胞具有促进合成和分泌作用。结论在白癜风的治疗中，驱虫斑鸠菊可增强酪氨酸酶活性，进而促进黑素合成

Aim:(1) The purpose of this study is to examine whether protein tyrosine kinase and AMPA receptor in the nucleus tractus solitarius and nucleus ambiguus were involved in the regulation of normoxia and hypoxia respiratory response by microinjection of PTK inhibitor and non-NMDA receptor antagonist;(2) To observe the change of number of phosphotyrosine immunopositive neurons in NTS and NA before and after hypoxia using immunohistochemical methods and whether tyrosine phosphorylation and GluR1 in postsynaptic membrane co-localize in NTS and NA neurons.

目的：(1)观察向家兔脑干孤束核或疑核内微量注射酪氨酸蛋白激酶阻断剂和谷氨酸AMPA受体阻断剂对常氧呼吸和低氧呼吸反应的影响，探讨PTK和AMPA受体在低氧呼吸反应中的作用。(2)观察低氧通气后NTS和NA磷酸化酪氨酸免疫阳性神经元的数量变化；观察磷酸化酪氨酸和AMPA受体亚单位GluR1在突触后膜共存的情况，推测在低氧呼吸反应中AMPA受体和PTK信号转导途径的关系。

1、Cur inhibits K562 cells growth and induces cell apoptosis may be correlated with the down-regulation of p210~、inhibition of protein tyrosine phosphorylation and the signaling molecules such as p-Erk1/2、c-myc which are relevant with cell growth and apoptosis; 2、Cur synergizes STI571 to inhibit K562 cell growth and induce cell apoptosis may be correlated with the down-regulation of p210~、inhibition of protein tyrosine phosphorylation and the signaling molecules such as Hsp90、PKC which are relevant with cell growth and apoptosis; 3、Cur reverses the resistance of K562/G01 cells to STI571, and synergizes STI571 to inhibit K562/G01 cell growth and induce cell apoptosis; 4、Cur inhibits human originated CML CD34~+ cell growth、induces cell apoptosis, and enhances STI571 to down-regulate the expression of p210~, finally inhibit cell growth and induce cell apoptosis.

从以上实验结果我们得出如下结论： 1、Cur抑制K562细胞增殖、诱导细胞凋亡的作用可能与其下调p210~、蛋白酪氨酸磷酸化水平以及抑制下游p-Erk1/2、c-myc等信号分子有关； 2、Cur协同STI571抑制K562细胞增殖、诱导细胞凋亡的作用可能与其下调p210~、蛋白酪氨酸磷酸化水平以及抑制Hsp90和下游PKC等信号分子有关； 3、Cur可逆转K562/G01细胞对STI571的耐药性，并与STI571协同抑制K562/G01细胞增殖和诱导凋亡，其抑制K562/G01细胞增殖、诱导细胞凋亡的作用可能与其下调p210~、蛋白酪氨酸磷酸化水平以及抑制下游Procaspase-3和NF-κB等信号分子有关； 4、Cur可抑制来源于CML患者骨髓的CD34~+细胞的增殖并诱导其凋亡，还可协同STI571下调CML CD34~+细胞p210~表达，进而协同抑制细胞增殖、诱导细胞凋亡。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。