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The absorption maxima and emission maxima didnt change obviously between the five-membered compounds when N-methyl as the bridge atom. The value of extinction coefficient was increased obviusly compared naphthalimide with naphthalic anhydride.

甲基化氮为桥原子的五元化合物之间最大吸收和发射波长相差不大,萘酰亚胺的消光系数比萘增加明显,loge最大相差可达0.45,荧光强度也略有增加,相差0.1左右。

Overloaded rat models were established by using abdominal aorta constriction method. The levels of creatinine and urea nitrogen in the rats?? serum as well as those of malonaldehyde and glutathion of the rats?? nephric tissue were measured respectively.

采用腹主动脉缩窄法制备压力超负荷大鼠模型,分别测定大鼠血清肌和尿素氮含量及大鼠肾组织匀浆丙二醛、谷胱甘肽含量。

The mouse was carried out half nephric duct ligation to induce the renal interstitial fibrosis animal model,afterwards,to set up three groups,control group,sham operation group(intragastric administration with normal sodium according to 10ml/kg weight),treatment group...

采用小鼠单侧输尿管结扎法诱导肾间质纤维化的动物模型,用盐酸青藤碱治疗,并设对照组、假手术组(小鼠每日按10m l/kg体重用生理盐水灌胃,直至治疗结束)、治疗组(选用正清风痛宁缓释片按每日30mg/kg体重给小鼠灌胃,连续3周,),检测血尿素氮、血肌、血清层粘连蛋白、纤维连接蛋白的含量,免疫组化法测肾脏组织转化因子β1(TNF-β1)的表达并进行肾脏病理学的观察。

The nephridial tissue of all the rats was taken for pathological examinations.

选用健康雄性SD(Sprague-Dawley)大鼠,腹腔注射8 mL/kg的DEG,于注射前和注射后第2天、5天、7天以及14天尾静脉采血检测血肌、尿素氮和CO2结合率(CO2CP),收集死亡大鼠及第7天和14天处死大鼠的肾组织进行病理检查。

Healthy SD male rats were given DEG with the dose of 8 mL/kg body weight (intraperitoneal injection I.P.). The level of the serum Cr, BUN and CO2CP(CO2 Combining Power CO2CP)were tested before and after the injection the 2nd , 5th , 7th, and 14th day. The nephridial tissue of all the rats was taken for pathological examinations.

选用健康雄性SD(Sprague-Dawley)大鼠,腹腔注射8 mL/kg的DEG,于注射前和注射后第2天、5天、7天以及14天尾静脉采血检测血肌、尿素氮和CO2结合率(CO2CP),收集死亡大鼠及第7天和14天处死大鼠的肾组织进行病理检查。

TCM group were intragastric administrated with Shenluotong 25 g/kg.d, Control group and the model group were intragastric administrated with benazepril 10 mg/kg.d, Normal group and model group were given equivalent physiological saline.24 hour urinary protein,Scr and BUN of different groups, and the expression of CTGF mRNA in nephridial tissue were detected.

检测各组大鼠24 h尿蛋白、血清尿素氮、肌和肾组织CTGF mRNA的表达。

Results Compared with CRF group, nephrogenic hypertension of hemin group was reduced significantly at the 6th, 8th, 10th week after operation, and followed with the decrease of serum creatinine, BUN,urinary protein and the improvement of nephrogenic anemia at the 10th week after operation. Hemin not only increased the expression of HO-1, reduced the expression of ET-1 in the kidney, but also increased the concentration of carbon monoxide, reduced the level of ET-1 in the plasm.

同时,在术后第10周hemin组比CRF组血肌、尿素氮、尿蛋白显著降低(P<0.05),贫血明显改善(P<0.05);肾组织中HO-1表达明显增加,血浆中内源性CO水平明显升高,肾组织和血浆中ET-1水平明显降低(P<0.05)。

The nitration of toluene was carried out in the presence of acetic anhydride with CCl4 as solvent, 95% nitric acid as nitrating reagent, and niobic acid calcinated at 300℃ for 3 h as catalyst for 60 min at 40℃.

实验结果表明,当反应温度为40℃,反应时间为60min时,以CCl4为溶剂,以质量分数为95%的硝酸为硝化剂,在醋存在条件下,以经300℃焙烧3h后的铌酸作为催化剂,甲苯硝化产物中异构体的邻对比达1.26,较硝硫混酸的1.67显著降低,产物得率达99.3%。

Urinary NAG activities were measured by nitrophenol colorimetric analysis technique.

用生化法测定血肌,用硝基苯酚比色法测定尿NAG。

Single-crystal X-ray diffraction analysis of 3, 3'-BTDA and 3, 4'-BTDA showed that they both have bent and noncoplanar structures.

发现螺双内酯在乙酸中回流可以直接有效地转化成二3,3'-BTDA,并提出了转化机制。

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