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Since 2002, Institute of Coal Chemistry, Chinese Academy of Sciences has been developing a new technology to prepare high-purity glyoxylic acid by maleic anhydride ozonation, which has been completed, and now the research of the downstream products of glyoxylic acid including vanillin, heliotropin and the substituted mandelic acid is underway.

中科院山西煤化所从2002年开始进行研究,完成顺臭氧化法制备高纯乙醛酸新技术工艺的开发,现正进行乙醛酸下游产品香兰素、洋茉莉醛、取代扁桃酸的技术研究。

Laboratory evaluation consists of hematocrit (hemoconcentration suggests preeclampsia), platelet count, protein excretion, serum creatinine, serum uric acid, serum alanine and aspartate aminotransferase concentrations, and lactic acid dehydrogenase concentration.

实验室评估包括红细胞压积,血小板计数,蛋白排泄,血肌,血尿酸,血清丙氨酸氨基转化酶和天门冬氨酸氨基转化酶,和乳酸脱氢酶浓度

The detection wavelength was selected at 220 nm. Results The method was linear over the concentration range of 2100 mgL^(-1) for creatine, uric acid, creatinine and hippuric acid and 100-1000 mgL^(-1) for urea. The mean recovery of the method was 97.6%-105.7%. The precisions were less than 4.2%.

结果肌酸、肌、尿酸和马尿酸的质量浓度在2~100 mgL^(-1)内、尿素的质量浓度在100~1 000 mgL^(-1)内线性关系良好,方法平均回收率为97.6%~105.7%,RSD均小于4.2%。

The detection wavelength was selected at 220 nm. Result The method was linear over the concentration range of 2–100 mg·L-1 for creatine, uric acid, creatinine and hippuric acid and 100 – 1000 mg·L-1 for urea.

结果 肌酸、肌、尿酸和马尿酸的质量浓度在2~100 mg·L-1内、尿素的质量浓度在100~1000 mg·L-1内线性关系良好,方法平均回收率为97.6%~105.7%,RSD均小于4.2%。

Objective To establish an RP-HPLC method for the simultaneous determination of 5 kinds of nonprotein-nitrogen metabolites in urine(urea, creatine, creatinine, uric acid and hippuric acid).

目的 建立RP-HPLC法同时测定尿液中尿素、肌酸、肌、尿酸和马尿酸5种非蛋白氮代谢产物。

Then the protected D-mannitol, mixed with lead tetraacetate, hippuric and acetic anhydride, were refluxed in THF for 18 h in a one-pot two step reaction to afford a chiral precursor-2-phenyl-4-[-2,3-O-]-propylidene-5(4H)-oxazolones.

产物与四乙酸铅、马尿酸、乙于THF中回流18 h完成一釜二步反应,纯化后得到含有手性碳原子的环丙烷氨基酸前体-2 苯基-4-[-2,3-O-]丙叉?

Results Compared with low-salt diet control group, the renal changes in CsA-L group were not obvious at the 2nd weeks, the urine volume and the level of BUN were remarkably increased in CsA-H group. At the 4th weeks, the urine volume was decreased; the levels of Crea and BUN were significantly increased and showed a significant positive correlation with the blood CsA concentration. Morphologic changes consisted of vacuolization of renal tubular cells, hyalinization of small arterioles and the light renal interstitial fibrosis.

结果 与低盐对照组相比,药后第2周CsA-L组各指标无明显变化,CsA-H组尿量增多,尿蛋白降低,尿素氮升高;药后第4周时,尿量呈减少趋势,肌和BUN明显升高,且与CsA血药浓度呈显著正相关,病理表现为肾小管细胞空泡变性及小动脉和肾间质病变,CsA-H组各种变化较CsA-L组更为明显。

Results CsA clearly decreased creatinine clearance and increased urinary excretion of N-acetyl-β-D-glucosaminidase in rats as compared with those in the vehicle group. Morphologic changes consisted of vacuolization of tubular cell, expansion of the interstitium and interstitial fibrosis, hyalinization of afferent arterioles. Severity of the injury was related to the dosage of CsA. Striped interstitial fibrosis and arteriolopathy were more severe in the rats treated with CsA and low-salt diet than with CsA and normal diet.

结果 用CsA的大鼠出现尿量增多、内生肌清除率下降、尿N-乙酰-β-D-氨基葡萄糖苷酶排泄增多等;病理上表现为不同程度的细胞浊肿、空泡变性及灶性分布的间质纤维化和小动脉病变,随CsA剂量的增加,病变呈加重趋势;结合低钠饮食,CsA慢性肾毒性病变明显加重。

Methods 36 cases of UE with sustaining hemodialysis between March 2008 and June 2009 was retrospectively analyzed,20 of which received hemoperfusion online continuous venovenous hemofiltrationand 16 only underwent continuous venovenous hemofiltration.Heartrates,mean arterypressure,APACHEII score,kalium ion,hydrocarbonic radical,blood urea nitrogenand serum creawere detected before and aftertherapy.

回顾性分析我院2008年3月至2009年6月维持性透析合并尿毒症脑病的患者36例,其中20例行血液灌流串联连续性静脉-静脉血液滤过,16例行单纯连续性静脉-静脉血液滤过,比较两组治疗前后心率、平均动脉压、APACHEⅡ评分、钾离子、碳酸氢根、尿素氮、血肌变化以及神经精神症状缓解情况和到达缓解所需时间。

Hematocrit and blood viscosity at shear rate in 150/s, 30/s, 5/s, 1/s, renal fibrosis serum markers, serum creatinine and blood urea nitrogen were detected respectively in sham operation and model group; microcirculation microscope was used to observe the thread of hypoglottis and auricle in rats.

建立单侧输尿管梗阻致大鼠肾间质纤维化模型,观察肾间质纤维化大鼠全血粘度150/s切变率、30/s切变率、5/s切变率、1/s切变率、红细胞压积、舌下及耳廓的脉络变化,同时检测肾纤维化指标、血清肌及尿素氮。

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