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METHOD The serum concentrations of AZP metabolite 6-Mercapto prine(6-MP) in different time were determined by reverse phase HPLC,when AZP was used alone and combined with Pred in nine rabbits.The pharmacokinetic parameters of the two groups wer statistically analysed by paired t test.

采用反相高效液相色谱法对单用硫唑嘌呤及醋酸泼尼松与硫唑嘌呤合用后,对家兔体内硫唑嘌呤的代谢产物六巯基嘌呤(6-MP)的血清药物浓度进行了测定,并对两组药物动力学参数进行配对t检验统计处理。

The frequency pairs of quadratical phase coupled harmonics are obtained by directly evaluating the generalized eignvalues of this matrix pencil without pairing.

通过直接计算该矩阵束的广义特征值确定二次相位耦合谐波频率对,从而避免解决配对问题。

Study Design. A retrospective, age- and sex-matched radiographic study.

研究设计:一个年龄、性别配对的回顾性影像学研究。

Recombinant human erythropoietin treatment in the anaemia associ atedwith multiple myeloma: case-control study Abstract Objective:To evaluate the efficacy of recomb inant human erythropoietin in the anaemia of multiple myeloma.

目的:评价重组人红细胞生成素多发性骨髓瘤贫血的效果。:采用配对方法观察Epo治疗MM贫血患者9例的治疗效果,使用剂量Epo为25~150 u/kg,每周3次皮下注射或静脉推注,连续治疗8周。

Heteroduplex molecules have been made by mixing pJSA1175 and pJSAl175ADRV4, pJSA1175ADRV4 and pJSAl175RRV4 DNA molecules which have been linearized by Pst Ⅰ and Bgl Ⅱ respectively, denaturing them in alkaline or high temperature, allowing them to renature and then spreading in the presence of formamide.

以痘苗病毒表达载体pJSA1175及重组质粒pJSA1175ADRV4(含ADRV VP4基因)、pJSA1175RRV4(含猴轮状病毒VP4基因)为材料,用碱变性方法或热变性方法制备了载体质粒与重组质粒DNA之间的异源双链,电镜下成功观察到载体序列部分经变性、复性后配对呈双链状态,而外源基因区域突出呈单链环状结构,测量长度为2.3kb。

Every wild animal, all cattle, every bird, and every repile that moves on the ground, came out of the ark by families.

各种地上生物:野兽、牲畜、鸟类和爬虫都是雌雄配对的,也都下了船。

Farmland green treefrog belonging to the family Rhacophoridae is endemic to Taiwan. The mating system of Rhacophorus arvalis is lek. From April 2003 to June 2004 at Yunling in central Taiwan, I investigated the lekking behavior and daily activity pattern, and analyzed the ecological factors on habitat to understand the lek preference in male frogs.

诸罗树蛙属於树蛙科为台湾特有种两栖类,其配对系统属於典型的群集展示系统。2003年4月至2004年6月间,研究者在云林县斗南镇观察记录本种树蛙的群集展示行为及日活动模式,并分析栖地的生态因子,以了解雄蛙对於展示场地选择之偏好。

Sepals oblong or linear, erect or spreading, base of lateral pair saccate.

萼片长圆形或线形,直立或开展,基于侧配对

Second, residues in the reactive site of the inhibitor were replaced by the consensus substrate recognition sequence of furin, namely, Arg at P_1, Lys at P_2, Arg at P_4 and Arg at P_6. In addition, the P_7 residue Asp was substituted with Ala to avoid possible electrostatic interference with furin inhibition. Finally, the extra N and C terminal residues beyond the doubly conjugated disulfide loops were further truncated. However, all resultant synthetic peptides were found to be temporary inhibitors of furin and kexin during a prolonged incubation, with the scissile peptide bond between P1 and P'1 cleaved to different extents by the enzymes.

高活性、低分子量的furin酶抑制剂有可能发展成为新型的抗细菌内毒素和抗病毒感染的药物,我们以绿豆胰蛋白酶抑制剂Lys片段长链22肽为模板,设计了一系列能抑制furin和kexin活性的突变体,采用如下三种方法逐步优化:一、去除Lys片段长链三对二硫键中的一对,用Ser替换Cys,减少可能存在的二硫键错误配对;二、抑制剂的活性中心根据furin底物的专一性逐步改变,即P1、P2、P4和P6位分别变为Arg、Lys、Arg和Arg,同时为了避免P7 Asp和P6 Arg之间可能存在的相互作用,将P7位Asp替换为Ala;三、将两对二硫键形成的双环的外面5个氨基酸残基去除。

When paired with cropped trenchcoats and slouchy sweatshirts bearing beaded epauletlike shoulders, the result was a vibrant sportswear collection the "gyp-setting" ADAM girl can pair with the existing contents of her closet or suitcase.

当搭配剪裁trenchcoats与肩膀覆满小珠的懒散的运动衫,结果是一个充满活力的运动装收集&诈骗设置&亚当女孩可以配对她的壁橱或手提箱现有的东西。

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She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了,但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场,你等着挨绳子吧!

Several theories about reigniting and extinguishing of the arc have been refered.

本文综合考虑了几种电弧重燃和熄灭理论。