配基

Fluouricil is usually used as anticancer drug, its derivative, 5-fluoro-uracil-1- acetic acid has good biological activity. Its complexes were presented in literatures. However, the coordination modes of it are paradox in literatures. The single crystal structure was resolved to clarify the confusion. The result indicates the carboxylic group coordinates to zinc ion in unidentate, and the heteroatoms of pyrimidine ring are not involved in coordination. Antitumor activity against SMMC-7721 was also examined.

7.5-氟尿嘧啶是临床上广泛使用的抗癌药物，它的衍生物5-氟尿嘧啶-1-乙酸亦具有良好的生物活性，有关它的金属配合物亦有报道，但其结构指认相当混乱，为此研究了它与锌的配合物单晶结构，证明了5-氟尿嘧啶以单齿羧基与锌配位，而嘧啶环氮并未配位，也研究了它对SMMC-7721细胞株的抗肿瘤作用。

The fluorescent emission mechanism, and the some factors that affect the energy and the intensities of the fluorescent peaks were studied. The strong powder second harmonic generation efficiencies for complexes (1),(2),(3) and (4) were found. The determination of variable-temperature magnetic susceptibility for complex (3) and complex (5) was performed. The magnetic data were analyzed with their structure properties, and the further information about the magnetic coupling capacity of Carbamyldicyanomethanide as bridging ligand was obtained.

测试了配合物(1)，(2)，(3)，(4)的荧光光谱，从配体的结构特点等方面研究了该荧光光谱的产生机理，研究了影响荧光谱峰能量及强度的因素；发现了配合物(1)，(2)，(3)，(4)显示有强的二阶非线性倍频效应；测试了配合物(3)和(5)的变温磁化率，对所得磁数据进行了结构性质分析，进一步获得了甲氨酰二氰基甲基阴离子作为桥联配体的磁耦合信息。

In this article,we report a study on the duplex stability affected by mismatches and insertions.The effects of the chemical nature,the positions,the numbers,and the cooperative behavior of mismatches as well as insertions on the 20-mer and 30-mer duplexes were examined.

在本实验中，我们系统地研究了20-mer和30-mer的杂交双链中错配与插入碱基的化学性质，位置，数目及协同效应对杂交双链稳定性的影响，总结了相关的稳定性趋势；应用温度梯度PCR实验来验证错配双链的不稳定性。

By utilizing three benezenemulticarboxylate derivatives (H2chdc, H2aip, NaH2sip), we obtain 12 coordination polymers. Especially, compelexes 1 and 2 are based on one-dimensional ···OHInOHIn···chains as building units, while complex 3 is based on double four-ring [In8(μ2-O)4(μ2-H2O)8]16+, complex 4 is based on trinuclear In3(μ3-O)(CO2)6, complexes 11 and 12 are both based on nested bistranded helices.

选择了三类取代苯羧酸配体： 2，5-二羟基-1，4-对苯二甲酸(2，5-H2chdc)； 5-氨基间苯二甲酸(5-H2aip)； 5-磺酸基间苯二甲酸钠盐(5-NaH2sip)和InCl3反应合成了十二个配位化合物：其中1、2以···OHInOHIn···链为构筑单元， 3以双四元环[In8(μ2-O)4(μ2-H2O)8]16+为构筑单元，4以棱柱状三核铟In3(μ3-O)(CO2)6为构筑单元，而11、12以嵌套的双股螺旋链为构筑单元。

These observations demonstrate that the alteration of the glycosidic group as well as its configuration does not,at least in the case of the above compound studied,interfer with the course of formatio...

以上的转化证明了配醣基的不同和构型的改变，至少在所研究的一个配醣物的结果来看，对于内醚环形成的构型是没有影响的。

It has been found that the DNA-binding mechanisms and oxidative cleavage of the macrocyclic single nuclear copper complexes are relevant to the rigidity of macrocycle, substitute groups on the side chain, the shape and structure of the complexes.

对一系列结构不同的单核铜配合物的研究表明，大环配体结构的刚性、配体支链上的取代基、配合物的形状与结构等因素对配合物与DNA的相互作用及对质粒DNA的氧化断裂有显著的影响。

Hydrolysis of the mischarged amino acids in theediting reaction will rely on the proper binding and correct recognition of both mainchain and side chain of the substrate. In general, the editing active site ofLeuRS-ED has a very rigid structure with a defined stereochemistry and usesa number of conserved residues to precisely bind and recognize the misactivatedamino acids and discriminate and reject the cognate amino acid, specifically usingMet336, Asp345, and possibly Thr247 for main-chain recognition and Thr252,Met336, and Val338 for side-chain recognition.

在编校反应中错配的氨基酸的水解依赖于对底物主链和支链的适当的结合和正确的识别。ecLeuRS-ED的编校活性位点有一个非常刚性的有很精确设计的立体化学性质的结构，采用一系列保守氨基酸残基来精确结合和识别错配的非共轭氨基酸而区分排斥正确的共轭氨基酸，具体就是采用Met336、Asp345，另外可能还有Thr247对底物主链进行识别，采用Thr252、Met336和Val338对支链进行识别。

In the third chapter, eight new complexes of 4, 6-dimethylpyrimidine 2-thioacetic acid with rare earth metals has been synthesized and characterized by means of elemental analysis, molar conductivity, IR,〓 NMR and TG-DTA. The general formula of the complexes is Ln〓(n=4 or 5). In the complexes, the deprotonated ligand coordinated to the rare earth metal ions in chelate bidentate mode. 4 or 5 molecular of crystal water existed in the complexes.

第三章合成了八种4，6-二甲基嘧啶-2-硫代乙酸的稀土配合物，通过元素分析、摩尔电导、红外光谱、核磁共振氢谱和热重-差热对配合物进行了表征，研究结果表明，配合物的组成为Ln〓n=4或5），在配合物中配体羧基脱去质子后采用螯合双齿的方式与稀土离子形成配位键，同时，配合物中含有4或5个结晶水。

The complexes areneutral as shown by values of molar conductivity in aqueous solution, namely,〓 The crystal structure determinations show that, in complexes, metal ions werecoordinated by four nitrogen atoms and form slightly distorted square planar configuration,relationship between fluorene ring plane and coordination plane is similar to those betweenpeptide planes of β-folding in proteins. The complex molecules linked by hydrogen bonds formone dimension chain or two dimension network structure.

摩尔电导测定表明他们都是二氧四胺中酰胺氮去质子化后形成的产物。X-射线衍射晶体结构测定表明〓的铜、镍配合物的配位多面体都是稍微畸变的平面正方形，配合物分子中芴基平面与配位平面的关系类似于蛋白质β-折叠结构中肽平面之间的关系，配合物分子之间通过氢键连接成一维链状或二维网状结构。

The experiment results indicate that higher phase splitting speed and extraction factor can be achieved when low-carbon alcohols such as n-butanol are used as organic solvents; by using five different N-carbobenzyloxy-L-amino acids as chiral ligands that are formated with Cu(superscript 2+) or Ni(superscript 2+), it is found that as a ligand, Z-Phe has a low extraction factor, while Z-Hyp, Z-Pro, Z-Glu, Z-Val have higher extraction factors, and among these, Z-Val has the highest distribution coefficient; pH value of extractant, when near to the PI of phenylalanine, helps to improve extraction resolution effect; temperature has no obvious effect on the resolution result.

结果表明：以低碳醇类正丁醇作有机稀释剂，所用5种N-苄氧羰基氨基酸（分别为Z-Phe、Z-Hyp、Z-Pro、Z-Glu、Z-Val）与Cu(上标 2+)或Ni(上标 2+)形成手性配位体后，以Z-Val作手性配体，萃取相pH值接近苯丙氨酸等电点时，萃取拆分效果最佳。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。