配体

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

WD40域，在真核蛋白质的数量发现，涵盖了包括各种功能适配器/信号转导，mRNA前体细胞骨架组装加工和管理模式；通常包含一个从11月24日生长激素肽的N残留端和西部数据肽在其C端和40残留长，因而得名WD40；介于生长激素和WD一个保守的核心，作为一个稳定的螺旋桨式平台，可以绑定的蛋白可以稳定或可逆，形成了一个螺旋桨式与每个刀片是一个四叶片结构组成若干链反平行的β-片；与数份检测实例假设，形成了聚大结构，每个WD40重复序列形成了前三个一个刀片和绞线的最后在未来的刀片链，最后C -末端WD40重复完成了第一WD40重复叶片结构，创造螺旋桨的封闭环结构，对螺旋桨顶部和底部表面残留的建议，配合和其他蛋白质的相互作用/或小配体； 7重复副本，目前这条路。

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.

WD40域，在真核蛋白质的数量发现，涵盖了包括各种功能适配器/信号转导，mRNA前体细胞骨架组装加工和管理模式；通常包含一个从11月24日生长激素肽的N残留端和西部数据肽在其C端和40残留长，因此得名WD40；之间的生长激素和WD是一个保守的核心，作为一个稳定的螺旋桨式平台，可以绑定的蛋白可以稳定或可逆性；形式与每个刀片是一个四叶片组成的几个类似结构的螺旋桨，搁浅反平行β-负债表；很少检测副本实例假设，形成了聚大结构，每个WD40重复序列形成了前三个链的一个刀片，并在未来的刀片上链，最后C -末端WD40重复完成了第一WD40重复叶片结构，创造螺旋桨的封闭环结构，对螺旋桨顶部和底部表面残留物，则建议协调与其他蛋白质和/或小配体； 7重复副本存在于相互作用这条路。

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are propos

WD40域，在真核蛋白质的数量发现，涵盖了包括各种功能适配器/信号转导，mRNA前体细胞骨架组装加工和管理模式；通常包含一个从11月24日生长激素肽的N残留端和西部数据肽在其C端和40残留长，因而得名WD40；介于生长激素和WD一个保守的核心，作为一个稳定的螺旋桨式平台，可以绑定的蛋白可以稳定或可逆，形成了一个螺旋桨式与每个刀片是一个四叶片结构组成若干链反平行的β-片；与数份检测实例假设，形成了聚大结构，每个WD40重复序列形成了前三个一个刀片和绞线的最后在未来的刀片链，最后C -末端WD40重复完成了第一WD40重复叶片结构，创造螺旋桨的封闭环结构，对螺旋桨顶部和底部表面残留的建议，配合和其他蛋白质的相互作用/或小配体； 7重复副本，目前这条路。

Copper ion was assembled onto DL-cysteine membrane that was directly assembled on the gold surface via Au-S bond, and then NAA was assembled onto the Cu/Cys/Au via coordinate function between NAA and Cu~(2+).

2利用过渡金属铜离子的桥联作用将萘胺乙酸作为桥联配体间接组装于单层膜Cys/Au上，构建另一类自组装多层膜体系NAA/Cu/Cys/Au。

The HμOR overexpressed in this study, with a tag of six consecutive histidines at its carboxyl terminus, will facilitate the future studies on exploration of reconstitution and structural basis of ligand recognition of HμOR.

我们在HμOR的C-端锚定六个连续的组氨酸（6His），将有利于HμOR的分离纯化，研究HμOR的重组和配体识别的结构基础。

The chiral ligands la-lf were used in the copper catalyzed asymmetric addition of diethylzinc to imines.

第二部分探索了一个新的含氮杂环丙烷的手性膦配体2的合成方法。

Catalytic enantioselective reduction of imines and enamines represents one of the most straightforward and efficient methods for the preparation of chiral amines, which are not only important building blocks of many natrural products and chiral drugs, but also can serve as useful resolution reagents, chiral ligands and chiral catalysts.

中文摘要手性胺不仅是许多天然产物和手性药物的重要结构单元，而且也是非常有用的拆分试剂、手性配体和手性催化剂。

Objective: To approach the possible effects of syndecan-4 in theformation of keloid and provided a new method to prevent and treat keloids.

目的探讨多配体蛋白聚糖—4(Syndecan—4简称SDC4)对瘢痕疙瘩形成的促进作用，为预防和治疗瘢痕疙瘩提供新思路。

The present invention prepares aldehyde or ketone by catalytic oxidation of alcohol under microwave irradiation, which takes sodium tungstate and tungstic heteropolyacid salts as catalyst, takes bidentate ligand containing nitrogen and oxygen as additive and takes hydrogen peroxide as preparing oxidant.

本发明以钨酸钠和钨的杂多酸盐为催化剂，以含氧氮的双齿配体作为助剂，以双氧水为氧化剂，在微波辐照下催化氧化醇制备得醛或酮。

When we used ligand 3k-Zinc in the asymmetric addition of phenylacetylene to ketones at room temperature, the highest ee was up to 85%.

当我们用配体3k-Zinc作为催化剂在对苯乙炔对酮的不对称加成反应中，产物最高的ee可达85％。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。