配体

The electron-rich and sterically hindered ligand 9d provides the best enantioselectivities (up to 97.8 % ee) for various chalcones as the substrates.

其中富电子且空间位阻较大的配体gd对查耳酮类底物表现了最好的手性诱导能力，加成产物的ee值达到94.7一97.8%。

Work 工作:(1) feasible process development for high-pure tetraalkyphosphonium salt as catalysts for polymerizations, potential sale 2-4 million us$;(2) simple and feasible preparation process for phosphonium salt as ionic liquids, biocides and phase transfer catalysts;(3) new and industrially feasible processes for highly sterically hindered alkylphosphines as catalyst ligands, these include tricyclohexyl-phosphine, phosphorinanes and dsmphos2,3- bis(9-phosphabicyclononylbutane;(4) sterically hindered dialkylphosphinic acid as new generation of co/ni extractant;(5) alkylphosphonium wittig reagents and the wittig reactions with them;(6) exploration of the application of borane chemistry in the synthesis of highly sterocally hindered organophosphines;(7) customer preparation of samples of a variety of organophosphorus compounds for customers all over the world.

用作高分子聚合反应催化剂的高纯度四烷基瞵盐的实用生产流程。产品销售前景 2-4 百万美元；(2)用作离子化液体，杀菌剂和相转移催化剂的烷基瞵盐的简单实用合成方法；(3)高位阻烷基磷化氢催化剂配体的工业实用合成路线的研究，这包括，三环己烷基磷， phosphorinanes 和 dsmphos 2，3-bis(9-phosphabicyclononylbutane ；(4)高位阻二烷基膦酸金属萃取剂的工业实用合成路线的研究；(5)烷基膦 wittig 反应试剂的研究；(6)硼化学在高位阻烷基磷化氢合成中的应用；(7)为世界各地提供顾客合成服务。

The ligand of the chiral Schiff base and acetylacetone vanadium are subjected to complexation in situ, hydrogen peroxide is taken as an oxidant, aryl alkyl thioether asymmetric oxidation reaction is catalyzed in a toluene or dichloromethane solution under low temperature or room temperature, enantioselectivity of chiral sulphoxide is 72 percent to 95 percent ee, and yield is 42 percent to 83 percent.

将上述手性西佛碱配体与乙酰丙酮氧钒原位络合，采用双氧水为氧化剂，在甲苯或二氯甲烷溶液中低温至室温下催化芳基烷基硫醚不对称氧化反应，手性亚砜的对映选择性为72％-95％ee，产率为42％-83％。

Basic on the special mechanism of action of Apo2L/TRAIL, the broad-spectrum antitumor activity and superordinary safety of recombinant human soluble Apo2L/TRAIL in preclinical researches, and the progression of the antitumor study on endogenous antiangiogenic factors, two studies were involved in this paper, including phase I clinical trial of rh-Apo2L and the study on expression of the fusion proteins of human Apo2L and endogenous antiangiogenic factors.

基于Apo2L／TRAIL独特的作用机制、重组人可溶性Apo2L／TRAIL临床前体现出的广谱的抗肿瘤作用和良好的安全性、以及内源性血管生成抑制因子抗肿瘤研究进展，本课题开展了下述两方面的研究：①国产重组人凋亡素2配体(rh-Apo2L)的Ⅰ期临床研究；②人Apo2L／TRAIL与人血管生成抑制因子融合表达的基础研究。

Hideyuki Doi, Nakui Madaki, Hrroshi, Hiromichi Komatsu, Keisei Fujimori and Susumu Satomi Tohoku. A New Preadipocyte Cell Line,AP-18,Established from Adult Mouse Adipose Tissue. J.Exp.Med,2005,207:209-216[2] Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPARγ 2, a lipid-activated transcription factor. Cell ,1994,79:1147－1156

PPARα调节脂肪代谢的机制总结如下：肝脏脂肪酸水平的增高激活PPARα，然后转录激活参与脂肪酸氧化的基因；配体与之结合后可激活编码乙酰辅酶A合成酶的基因，同时PPARα激活后可调节脂肪转运相关基因的表达如PPARα升高高密度脂蛋白和抑制ApoC－Ⅲ的表达。

They play a pivotal role in the regulation of synaptic transmission and synaptic plasticity in the central nervous system.

NMDA受体是包含谷氨酸和甘氨酸结合位点的配体门控性离子通道，在中枢神经系统的突触传递和突触可塑性调节中起着重要的作用。

Many chemists focus on the design and syntheses of small molecular ligands of biological receptors.

用于研究生物受体的有机小分子配体的分子设计和合成已成为许多化学家研究的焦点。

After treated with CuAz, the hydrogen from phenolic hydroxyl group in lignin was replaced by Cu from treated solution, being N-Cu-O complex, or two of the ammonia ligands of the tetrammine complex were replaced by copper-oxygen bonding from hydroxyl, being Cu-N-lignin complex.

在铜唑防腐剂处理后，木质素上酚羟基的H可以被Cu取代，形成&N-Cu-O&形式的络合物；或者处理液中四氨络合物中的2个氨配体被羟基取代，形成芳香族-铜络合物。

Synthesis, molecular structure and magnetic properties of tetranuclear copper complexes with pendant-arm macrocyclic ligands.

主研方向：金属离子导向的分子自组装研究，新型大环配体的设计与合成及其离子和分子识别研究，新药开发与铂药物筛选。

Two of the four alcohol oxygen atoms O3 in theligands act as oneμ2 bridged atom and the other two O6 act asμ3 bridge to link to Cuatoms together, resulting in the tetranuclear structure.

而立方烷型四核铜骨架配合物是分子中四个Schiff碱配体各提供一个亚氨基N、一个酚基O和一个醇羟基O，与四个Cu一起形成立方烷型四核铜骨架。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。