配体

AIM: To synthesize 2 novel chiral ligands derived from cinchona alkaloids and study their catalytic performance in asymmetric dihydroxylation of 5 olefins.

目的：合成两种新的金鸡纳生物碱类衍生物配体并将其用于催化五种烯烃的不对称二羟化反应，考察催化效果。

In the synthetic procedure to chiral docetaxel C13 side chain, the expensive cinchona alkaloid derivatives can be recycled, which dramatically decreased the reaction cost.

在多烯紫杉醇手性C13侧链的合成过程中，对价格昂贵的金鸡纳生物碱衍生物配体进行了回收和再利用，大大降低了反应成本。

METHODS: Inexpensive quinine and cinchonine were transformed to 9NH2quinine and 9NH2cinchonine, which reacted with 4chlorobenzoyl chloride to afford 2 novel chiral ligands. The AD reactions of olefins were performed in H2OtBuOH (1∶1) using the 2 ligandsK2OSO24 as catalysts.

以价廉易得的奎宁和辛可宁为原料，经过结构转换得到9氨基奎宁和9氨基辛克宁，进而与对氯苯甲酰氯反应制得两种新型手性配体，并将其用于锇催化的烯烃的不对称双羟化反应。

Complete chiral induction from enantiopure-DPEN to achiral bisphosphine ligand 3a was observed in solution, with the complex adopting a single, stable and non-fluxional (even at 70 ℃) configuration.

光学纯-DPEN在溶液中对非手性双膦配体3a产生完全的手性诱导，形成构型单一的稳定RuII络合物，即使在70°C下构型仍保持不变。

Moreover, the concision of synthetic route and the stability of ligand were also pursued goals.

同时，合成方法的简单和配体的稳定也一直是研究人员的追求目标。

The effects of pH and matrix on the intensity of RRS were analyzed based on the conditional stability constant and matrix effect.

它利用待测物与配体缔合后，生成的缔合物因疏水作用聚集形成纳米粒子，能产生强烈的共振散射，从而对待测物进行定性、定量分析。

One important aspect in correlation between structure and function is the ability of recognition and bond between proteins and ligands.

蛋白质结构与功能间关系的一个重要方面是蛋白质与配体的识别和结合能力问题。

The copolymerization of cycloolefin and α-olefin, and structure of the obtained polymer are significantly affected by the structure and symmetry of metallocene catalysts, electronic effect and steric hindrance of ligands.

着重介绍了加成聚合法中茂金属催化剂的结构对称性、配体的电子和体积效应、反应条件等对聚合活性、产物组成与序列分布及相关热性能的影响。

The copolymerization of cycloolefin and α-olefin,and the structure of the obtained polymer are significantly affected by the structure and symmetry of metallocene catalysts ,electronic effect and steric hindrance of ligands.

着重介绍了加成聚合法中茂金属催化剂的结构对称性、配体的电子和体积效应、反应条件等对聚合活性、产物组成与序列分布及相关热性能的影响。

(1) Exon 6,7,8 have no relation with the susceptibility of HCV infection. The genetic basis of the four amino acids is highly conserved in Chinese population. Because other sites of CD81 protein are highly conserved among species, there is no or very rare polymorphism of CD8I in Chinese people.(2) The susceptibility of HCV infection has nothing to do with the genetic basis of the ligand binding region of LDLR.Postgraduate DongQiumingDirected by Professor Gao Jinsheng Professor Lu Daru

（1）CD81外显子6、7、8与HCV感染的易感性无关，以上四个氨基酸的遗传基础在中国人中是高度保守的；由于CD81蛋白的其它位点在种间是高度保守的， CD81，LDLR单核菩酸多态拄与丙型肝炎病毒感染易感性的相关性研究摘要因此，在中国人群中 CDSI蛋白的多态性稀少或不存在。u）HCV感染的易感性与LDLR的配体结合结构域的遗传基础无关。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。