配体

Methods Accelerated rat crescentic nephritis were induced by rabbit anti-rat GBM nephrotoxic serum.

目的 探讨CD44及其配体骨调素在实验性新月体肾炎发展过程中的表达和作用。

NMDA(N-methyl-D-aspartate) receptors are a subtype of excitatory transmitters-glutamate receptor which belong to a heteromeric ligand-gated ionotropic receptors and play an important role in many complex physiological and pathological processes, such as nerve development, neuronal excitatory synaptic transmission, synaptic plasticity, central sensitization and neuronal death.

NMDA(N-methyl-D-aspartate)受体是兴奋性神经递质谷氨酸受体的一种亚型，是一种异聚体配体门控型离子通道，参与体内神经发育、神经元的兴奋性突触传递、突触可塑性、中枢敏化、神经元死亡等多种不同的生理和病理过程。

Methods Fibroblastic stromal cells were isolated from fresh pseudomembrane from 7 patients undergoing revision arthroplasty for aseptic loosening of the hip and cultured in the presence and absence of bone cement (PMMA+BaSO4) particles.

酶消化法从人工假体周围假膜标本中分离FBSCs并作体外培养并加入骨水泥颗粒，检测FBSCs核因子kB受体激动剂配体和肿瘤坏死因子mRNA表达的变化。

Both iron atoms of the binuclear unit are bridged by one oxy atom and two acetate groups. Each iron atom is also bound to facially - coordinating tridentate IDB ligand with the aliphatic nitrogen donor situated trans to theμ- oxy atom. Each iron centers is in a distorted octahedral symmetry.

每个双核单元的两个铁原子均通过一个氧原子和两个醋酸根连接，每个铁原子同时还与位于桥氧原子对位的三齿配体IDB重脂肪链上氮原子相结合，每个铁中心为一变形八面体结构。

SAA ligand Lg could catalyze asymmetric addition of phenylacetylene to unactivated aromatic ketones in high yields (up to 83%) and high enantioslectivities (up to 83%ee).

SAA配体Lg用于催化炔基锌对未活化酮的不对称加成反应，对于芳香酮的催化反应，收率可达83%，对映体选择性可达83%ee。

AR signalling can be activated in HR tumours through several mechanisms. First, activation of intracellular signal transduction pathways can sensitize the AR to castrate levels of androgens. Also, mutations in the AR can change AR ligand specificity, thereby allowing it to be activated by non-steroids or anti-androgens. Finally, overexpression of the wild-type AR sensitizes itself to low concentrations of androgens.

HRPC的AR信号通路活化机制包括：胞内信号传导途径可以增加 AR对于去势治疗后低水平雄激素的敏感性；AR的突变也可改变其对于配体的选择，使得非甾体类激素甚至抗雄激素药物也能够激活AR；此外，野生型AR的过表达也促进了自身对于低浓度雄激素的敏感性。

Chiral SalanCrX complexesa saturated version of SalenCr(ⅢX are designed,and in conjunction with an ionic quaternary ammonium salt or organic strong base can efficiently catalyze the asymmetric,regio-and stereoselective alternating copolymerization of CO_2 with rac-PO at mild conditions to afford isotactic-enriched polycarbonates with～95%head-to-tail linkages and moderate enantioselectivity.

本论文在Salen构型配体的基础上，设计合成了一系列手性Salan型铬配合物，并将其与季铵盐/有机强碱组成亲电-亲核双组分催化体系，在室温下可以有效的催化CO_2和环氧丙烷的不对称交替共聚反应，实现了CO_2和环氧丙烷的不对称交替共聚反应的区域和立体化学控制，得到95%的头尾连接单元和中等光学纯度(对映体过量值ee%≈70%)的全同结构的聚碳酸酯。

The incline and base structure, carton ring and mainframework, second grade structure and fag end, cooperating structure of metalloprotein,crystal structure of collagen peptide, hydration structure and multi-gather structurewere studied accordingly.

直观地观察了氨基酸的倾向结构和底部结构、卡通环和主骨架、二级结构和末端、金属化合物的配体结构、胶原肽的晶体结构、水合结构以及多聚体结构等。

It has been tried to in- duce active hydrolytic grop to the ligands of BAT, attempting to use chemical hydrolyses instead of biological hydrolyses to find ide- al brain radiopharmaceuticals. However, because of the immense work, the shortage of funds, only the syntheses of some latents have been done in this theses, and further study is still needed.

本论方中企图通过对BAT类配体引入活泼水解基因，采用化学水解代替生物水解找到理想的脑放射性药物，但因工作量大，消耗经费等问题，本论文中只作了一些潜体的合成，有关工作，有待于进一步研究。

The stability constants for the new macrocycle and binary complexes of the amino acid with the macrocyclic ligand are reported.

大环多胺配体对各种小分子的识别与大环的腔体大小、环的刚性程度及环上取代基的性质有关。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。