部分抗原

Since 1997, the goose flocks in some regions of South and East China have experienced severe outbreaks of Newcastle disease virus infection. The results of the in vitro tests indicate that the goose isolates have stronger ability to induce syncytium formation, when compared to chicken and pigeon isolates.

1997年以来我国华南和华东部分地区发生了由新城疫病毒(Newcastle disease virus， NDV)导致的鹅的临诊疾病，而且发现鹅源NDV在体外具有比鸡源和鸽源毒株更强的致细胞融合的能力，这表明NDV的抗原可能发生了变异。

Based on the above-mentioned, two kinds of target glycoclusters with different glycoterminus, flexible linkers and different scaffolds were designed, disaccharide glycocluster (including TM1-TM7) and trisaccharide glycocluster (TM8-TM9) respectively, with the purpose of obtaining glycoclusters with high binding affinity to anti-Gal antibody and thus better inhibiting the HAR.

基于上述，针对HAR产生的机制，以人体中天然存在的anti-α-Gal抗体及B细胞表面的相应受体为靶点，以α-Gal抗原末端的二糖Galα1→3Gal和三糖Galα1→3Galβ1-4GluNAc片段为糖基部分，采用柔性的连接臂（氨基保护的2-乙醇胺和3-巯基丙酸）和刚性的芳香骨架及柔性的脂肪链骨架，设计了两类结构新颖的糖簇分子：即氧苷和硫苷键连接的二糖糖簇TM1-TM7）和三糖糖簇（TM8-TM9），目的在于寻找与anti-Gal抗体及B细胞相应受体有较高结合力的糖簇分子，以便有效地抑制HAR反应的发生。

Methods: the first experiment Immunetolerance in mice sciatic nerve allograft by intrathymic injection of allogene: 48 mice were divided into 4 groups randomly: Group A,Group B, Group C and Group D(nerve allograft under immunosurppressant).

研究技术路线：第一部分：小鼠胸腺内注射异基因抗原在同种异体坐骨神经移植免疫耐受中的作用 1、动物分组：48只Balb／c小鼠随机分为4组，A组；B组；C组；D组(异体神经移植加用免疫抑制剂组)。

Twenty five patients with gastritic carcinoma were vaccined with dendritic cells pulsed with tumor antigen and T cell subsets of peripheral blood, Th1 type and Th2 type (IL-4) cytokines of these patients serum were detected at different time point.

第三部分，从外周血诱导制备DCs疫苗，皮下注射治疗25例胃癌患者，初步观察DCs疫苗治疗前后胃癌患者迟发性超敏反应，T淋巴细胞亚群，NK细胞，外周血清IFN-γ、IL-4的水平及外周血PBMC在自体肿瘤抗原刺激下分泌IFN-γ、IL-4的能力。

The partial nucleotide sequence of the gene fragment showed high homology with the essential spectrin gene of Caenorhabditis elegans and the erythrocyte surface antigen gene of Plasmodium falciparum , when the gene fragment was homologically analyzed in GenBank.

与GenBank中的基因进行同源性分析，其部分核苷酸序列与秀丽隐杆线虫红细胞膜内蛋白和恶性疟原虫红细胞表面抗原高度同源

In the last part, a coordination control strategy of multi-controller is proposed on basis of idiotype immune network and coordination mechanism among multi-antigen and multi-antibody.

第四部分介绍了独特型免疫网络，以及在此基础上的多抗原多抗体之间的协调作用机制，提出了多个控制器的协调控制策略。

More than 6% of total bacterial proteins were soluable and can be detected in the part of periplasm, which can bind with rhuTNF α by E...

这部分可溶性的表达产物占菌体总蛋白的6％，经双抗体夹心法和斑点印迹分析表明它具有抗原结合活性

ANP and CX43 began to express at 2nd week after induction and increased gradually,about 60% of the resulting myogenic cells were positive at 4th week after induction ,they were negative for uninduced cells.hMSCs'surface antigen profiles obtained by Flow Cytometry were negative for CD31\CD34\CD45 before and after induction,but CD90 expressed higher after induction while was weak positive before induction(P.05). Apotosis index was correlated with the cultural time after induction,The apoptosis rate of induced hMSCs was remarkably higher than control group(P.01),and the variation between groups was notable(P.05),the cell cycle analysis showed that the percentages of G_0/G_1phases were reduced significantly after induction. The expresstion levels ofβ-MHC and CTNT mRNA were undetectable before induction,began to increase at 1st、4th week after induction,reached the peak at 6th week and decreased after that,the expression of Bcl-2 and Bax mRNA varied regularly after treated with 5-azacytidine. hMSCs'resting membrane potential、range and rate of depolarization were heightened gradually after being induced.

结果：hMSCs诱导前为纺锤形，诱导后第2天部分细胞即开始发生形变，呈球形或短棒状，1周后胞浆中颗粒增多，约20～30%细胞边缘呈毛刷样变化；hMSCs表面抗原CD31、CD34、CD45在诱导前后差异无统计学意义，CD90未诱导时表达呈弱阳性，诱导后明显增高(P.05)；ANP和CX43在诱导前无表达，诱导后第2周开始表达且表达随时间逐渐增强，但CX43在诱导后第5周表达量开始降低。hMSCs诱导后凋亡指数随诱导后培养时间增加，低浓度诱导组低于标准浓度诱导组，组间差异有统计学意义(P.05)，G_0/G_1期细胞比例诱导后较对照组显著减少(P.05)；β-MHC和CTNT基因分别在诱导后第1周和第4周时表达开始增强，在第6周时均达到高峰，第8周时表达开始衰减，Bcl-2、Bax基因表达呈时间依赖性变化，hMSCs经诱导后随心肌样细胞特征的表达膜静息电位、去极化幅值和去极化速率逐渐增高。

The promoter and partial GAG domain of CFG1 element are unmethylated, however, the partial RT domain is highly methylated.

CFG1元件的启动子和部分组特异性抗原域处于未甲基化状态，而部分RT域则处于高度甲基化状态。

Results No apparent cytopathic effects could be observed during the first 24 hours of infection with L-form and elementary bodies, but the cytoplasm of some MA104 cells became vacuolated when the L-forms entering into the cells as shown by immunohistochemical staining and PCR.

结果 发现金葡菌L型及滤过的原生小体对细胞致病性降低，细胞不出现明显病变，部分细胞出现空泡样变，免疫组化及金葡菌PCR显示感染细胞内出现金葡菌抗原及DNA。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。