邻苯二酰

Benzyloxy benzoyldimethylsulfoxide was prepared by the reaction of ethyl 4-benzyloxybenzoate and dimethyl sulfoxide in the presence of sodium hydride, followed by Pummerer reaction with concentrated hydrochloric acid to afford eo-hydroxy-co-thio-methyl-(4/-benzyloxy) acetophenone, which reacted with urea, thiosemicarbazide, semicarbazide hydrochloride and o-phenylenediamine to give imidazolidine-2,4-dione, l,2,4-triazine-3- one and quinoxaline derivatives, respectively.

本文用4-苄氧基苯甲酸乙酯和二甲亚砜为原料，在氢化钠存在下反应，合成了(4′-苄氧基)-苯甲酰基-二甲亚砜。研究了该亚砜在浓盐酸的存在下发生的Pummerer重排反应，用重排产物ω-羟基-ω-甲硫基-(4′-苄氧基)-苯乙酮分别与尿素、氨基脲、氨基硫脲和邻苯二胺反应合成了2，4-咪唑啉-二酮、1，2，4-三嗪-3-酮、喹喔啉等含氮杂环化合物。

Products: 3 - benzoyl-ethyl acrylate (97% min), acyl phosphorus acid methyl ester (98% min), P acyl three ethyl acetate (98% min), a phosphorus acid acyl The ethyl esters (98% min), 3 - bromine -1,3,4,5 - tetrahydrocannabinol -2 H-1-benzo-Aza Zhuo -2, 1 - naphthalene-tetrahydrocannabinol (98% min), 3,5 - dimethyl benzoyl chloride (99% min), 3,5 - dichloro benzoyl chloride (97% min), the ethyl benzoyl chloride (99% min), a TCA Ester (99.5% min), o-benzoyl methyl benzene (99% min), 4 - phenyl benzophenone (99% min): glacial acetic acid (99% min), methanol (99% min), liquid chlorine (99.5% min), caustic soda (30% min), isopropyl alcohol (99% min), anthranilic acid (99% min), dichloroethane (99% min ), Chunben (99% min), toluene 99% min

3-苯甲酰基丙烯酸乙酯（97%min）、磷酰基乙酸三甲酯（98%min）、磷酰基乙酸三乙酯（98%min）、磷酰基乙酸甲酯二乙酯（98%min）、3-溴-1，3，4，5-四氢-2H-1-苯并氮杂卓-2酮、1-四氢萘酮（98%min）、3，5-二甲基苯甲酰氯（99%min）、3，5-二氯苯甲酰氯（97%min）、对乙基苯甲酰氯（99%min）、氯乙酸甲酯（99.5%min）、邻苯甲酰基苯甲酸甲酯（99%min）、4-苯基二苯甲酮

Phthalimide,anthranilic acid,2methyleneglutaronitrile bromina 1bromobutane 1,2benzisothiazole3one.

邻苯二甲酰亚胺，邻氨基苯甲酸，2亚甲基戊二脯，2溴2溴甲基戊二脯，溴代正丁烷，1.2苯并异噻唑3酮。

This dissertation is mainly focused on the reactivity of methylenecyclopropanes and comprises six parts. 1 The reactions of methylenecyclopropanes with phenylsulfenyl chloride, phenylselenyl chloride and diphenyl diselenide; 2 The coupling reactions of the ring-opening products derivated from methylenecyclopropanes; 3 The palladium-catalyzed ring-enlargement of mono-aryl group substituted methylenecyclopropanes to cyclobutenes. 4 The gold-catalyzed domino ring-opening and ring-closing hydroamination of methylenecyclopropanes with sulfonamides; 5 The Lewis acid-catalyzed reactions of mono-aryl group substituted methylenecyclopropanes with diethyl ketomalonate in the presence of water; 6 The iodobenzene diacetate mediated novel 1,3-dipolar cycloaddition of methylenecyclopropanes, vinylidenecyclopropanes, and methylenecyclobutane with phthalhydrazine.

本论文主要研究了亚甲基环丙烷类化合物的一些化学反应性能，共由以下六部分组成：1、亚甲基环丙烷类化合物与苯硫氯、苯硒氯及二苯基二硒的反应；2、亚甲基环丙烷类化合物开环产物的偶联反应；3、单芳基取代的亚甲基环丙烷类化合物在钯催化剂作用下的扩环反应；4、金化合物催化磺酰胺对亚甲基环丙烷类化合物的串联开环关环氨氢化反应；5、路易斯酸催化亚甲基环丙烷类化合物与丙酮二羧酸二乙酯在有水存在下的反应；6、醋酸碘苯促进的亚甲基环丙烷类化合物、亚乙烯基环丙烷类化合物及亚甲基环丁烷类化合物与邻苯二甲酰肼的新型1，3-偶极环加成反应。

Afterwards, N-(6-chloro-3-pyridinemethyl) phthalimide is prepared by using potassium phthalimide, as nucleophilic reagent, condensation reacting with 2-chloro-5-methylpyridine at a temperature of 70℃.

然后在70℃条件下，以邻苯二甲酸亚胺钾作为亲核试剂，与2-氯－5-氯甲基吡啶发生缩合反应，制备了N-（6-氯－3-吡啶甲基）邻苯二甲酰亚胺。

By using 4-chloro-5-nitro phthalimide as raw material and through aminoysis, reduction, cyclization and hydrolysis, end-produce benzimidazole-5,6-diformic acid is prepared.

本发明公开了一种苯并咪唑－5，6－二甲酸的制备方法。该方法是以4－氯－5－硝基邻苯二甲酰亚胺为原料，依次经过氨解、还原、环合、水解反应过程，制得最终产品苯并咪唑－5，6－二甲酸。

Third, we studied the N-alkylation of phthalimide, indole, benzimidazole, succinimide with a variety of halogen in ionic liquid [BF4], [PF_6]. The present method has many obvious advantages, compared to those reported in the literature, including the generality, simplicity of the methodology, the ease of product isolation, the higher yield and potential for recycling of ionic liquids.

第三、研究了离子液体[BF_4]、[PF_6]和BF_4促进邻苯二甲酰亚胺、吲哚、苯并咪唑、丁二酰亚胺的N-烷基化反应，克服了传统溶剂中进行N-烷基化反应要求强碱、反应条件苛刻、时间长、产率一般的不足，改善了反应条件、提高了产率。

To explore new synthetic methods, we set out a careful investigation of the reaction of benzimidazolium salt with many nucleophilic agents, including the active aromatic compounds and heteratom nucleophilic agents, and found that the quaternary C=N is not so active; when benzimidazolium salt is reacted with big nitrogen nucleophilic agent? phthalimide, it does not give the expected addition product, instead, produces N-alkyl phthalimide through alkyl-transfermation from benzimidazolium salt to phthalimide.

为了开发新的合成方法，研究了苯并咪唑盐与各种亲核试剂（活泼芳环与杂原子亲核试剂）的反应，发现苯并咪唑盐不与活泼芳环及杂原子亲核试剂发生2位加成反应；在与体积较大的位阻型N亲核试剂邻苯二甲酚亚胺反应时，未得到亲核试剂与极化的C＝N的加成产物，而是得到N烷基化的邻苯二甲酰亚胺，进一步研究表明，苯并咪唑盐将1（3）位N上的烷基转移给了邻苯二甲酰亚胺，并讨论了其反应机理和取代基，溶剂效应。

Seven of them have not been reported.Their structures were confirmed by IR,~1HNMR,MS,and element analysis. 4.Meanwhile,the green methylation procedure of imides was developed by using dimethyl carbonate as methylation reagent.A series of imides,for example,phthalimide,3,4-dibromo-maleimide and succincide were used for substrates.The effects of DABCO(1,4-diazabicyclo [2.2.2]octane)and DBU(1,8-diazabicyclo[5.4.0]undec-7-ene)as a catalyst in this kind of reactions were investigated.2-Bromo-3-(1-methylindolyl-3-yl)-1-methyl-1H-pyrrole-2,5-dione was prepared by using dimethyl carbonate,which further expanded the use of dimethyl carbonate,as a green agent in organic synthesis.

在以硫酸二甲酯为甲基化试剂对3，4-二溴马来酰亚胺进行N-甲基化反应合成3，4-二溴-N-甲基马来酰亚胺的同时，以碳酸二甲酯为甲基化试剂，对3，4-二溴马来酰亚胺、邻苯二甲酰亚胺、琥珀酰亚胺等酰亚胺类化合物的N-甲基化反应进行了研究；考察了1，4-二氮杂双环[2.2.2]辛烷，1，8-二氮杂双环[5.4.0]十一碳-7-烯、碳酸钾和四丁基溴化铵等作为催化剂对碳酸二甲酯N-甲基化反应的反应时间和收率等的影响，并应用碳酸二甲酯为甲基化试剂，合成了N-甲基-3-溴-4-(1-甲基-吲哚-3)-马来酰亚胺。

Amino-monomethoxypoly(ethy1ene glycol)(mPEG-NH2) was synthesized based on the principle of Gabriel synthesis.Monomethoxypoly(ethy1ene glycol) tosylate was prepared at first,and then reaction with potassium salt of phthalimide as nucleophile to produce the monomethoxypoly(ethy1ene glycol)phthalimide derivative.

摘 要：首先合成了单甲氧基聚乙二醇对甲苯磺酸酯，然后根据盖布瑞尔合成法原理，以邻苯二甲酰亚胺钾盐为亲核试剂与mPEG-OTs反应，生成单甲氧基聚乙二醇的邻苯二甲酰亚胺衍生物，mPEG-PI与水合肼反应肼解生成伯胺，合成了一端为氨基的单甲氧基聚乙二醇(mPEG-NH2)。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。