遗传学

Purpose To investigate the clinicopathological feature, immunophenotype and genetic of anaplastic large cell lymphoma, sarcomatoid variant.

目的 探讨肉瘤样型间变性大细胞淋巴瘤临床病理特点、免疫表型及分子遗传学特征。

Lead author Indrani Sarkar of the Max Planck Institute for Molecular Cell Biology and Genetics in Dresden, who co-partnered the breakthrough, said, The most important, and likely most difficult, among these is that the enzyme would need efficient and safe means of deliery and would hae to be able to function without aderse side effects on humans.

德累斯顿分子细胞生物学和遗传学Max Planck研究所的前驱者，也是这个突破的合伙人 Indrani Sarkar 说，这其中最重要的，可能也是最困难的是，这个酶去除的方式要是有效的和安全的，并且在作用时对人体没有不良副作用。

All the LOH on 〓 and 〓 was observed in invasive ductal carcino- ma, carcinoma simplex, medulary carcinoma and scirrhous carcino- ma, no deletions at these sites were observed in any invasive lobular carcinoma and others. These results imply an etiological difference.P53 gene is a hot point gene in the occurrence and development of breast, cancer. PCR-SSCP analysis was performed to detect P53 gene point mutation in the region between exon 5 and 8, 5 of 12 (41. 6%) stage I breast cancer patients contain mutation of P53, 3 of 5 patients were accompanied by 〓 deletion. These results suggested that point mutation and allelic loss of P53 gene are two vi- tal genetic events in earlier stage of breast tumorigenesis.

我们还发现，〓和〓位点LOH均分布在乳腺浸润性导管癌、单纯癌、髓样癌及硬癌中，在浸润性小叶癌和某些特殊类型乳腺癌中全部为LOH阴性，上述位点LOH可能与某些组织学类型乳腺癌的发生有关。P53基因是乳腺癌形成过程中的一个热点基因，本研究对12例Ⅰ期乳腺癌组织标本中P53基因热点区域第5、6、7、8外显子点突变进行了测定，发现41.6％（5／12）的病人有P53基因一个或多个点突变，其中3例同时伴有〓位点LOH，表明P53基因点突变和等位基因缺失是发生在乳腺癌形成早期的一个重要遗传学事件。

Because of illness, lack of space to exercise, and genetic manipulation that forces them to grow too big too fast, pigs often develop arthritis and other joint problems.19 Many pigs on factory farms live on slatted floors above giant manure pits.

因为疾病，缺乏运动和遗传学操作，猪会长得过大过快，致使它们患上关节炎和其他关节方面的疾病。在工业化农场，猪都住在有空隙的狭板地板上，下面则是巨大的粪池。

It has also become a good model system to study cross-talk of different plant hormones with the development of genetics and whole tomato genome sequencing from International Solanaceae Genomics Project.Jasmonic acidis a fatty acid-derived signal and exists in the plant kingdom extensively.

番茄是最重要的蔬菜作物之一，随着番茄遗传学研究和国际茄科基因组计划(International Solanaceae Genomics Project，SOL)的发展，番茄已成为研究植物激素相互作用的理想模式植物。

Epigenetics is the study of processes that establish metastable that is, somatically heritable state of gene expression without altering the sequence.

表观遗传学是研究没有DNA序列变化，但可遗传的基因表达的改变。

The phylogenetic relationship of the two types in Sparidae are also discussed in this paper and it is believed that the two types are of divergent evolution in Sparidae .

此外，还讨论了这两种鱼的亲缘关系和鲷科鱼类中两个类群及其核型的分化问题，认为从细胞遗传学角度看，鲷科鱼类的两个类群在演化过程中是分支进化的。

These results suggest that P300 reduction in both symptomatological and genetic high risk groups of schizophrenia might have different origin of disturbance in the neural circuitry for P300 generation.

这些结果提示分裂症的症状学及遗传学高危人群存在 P300 减少，且可能存在有不同 P300 神经通路的失调。

Methods: For 4 tetrameric STR loci (D5S818, D8S1179, D18S51and D21S11) genetic research, monoplex PCR methods were established to study the allele frequency and the applicability of forensic medicine.

应用聚合酶链反应，聚丙烯酰胺凝胶电泳及银染分型技术，对延边地区109名朝鲜族无关个体进行群体调查，获得四种基因座的群体遗传学资料。

As for the molecular genetics of plasmids in thermophilic bacteria, only preliminary observation of very few phenomena has been reported so far.

在高温细菌质粒的分子遗传学方面，已发表的少量文献仅限于对个别现象所作的初步描述。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。