遗传学

Objective: To identify EDA gene mutation in a pedigree of Han nationality in Xinjiang with X-linked hypohidrotic ectodermal dysplasia so as to provide a basis for gene and genetics diagnosis of this disorder.

目的：检测一新疆汉族X连锁少汗性外胚叶发育不全家系引起先天缺牙的EDA基因突变，为XLHED综合征的基因和遗传学研究提供理论依据。

This research, which provides new molecular level data for species identifying and resources evaluation of different geographical Engraulis japonicus populations in Huanghai and Donghai sea areas, fills up the blank in the fields of population genetics and molecular biology of marine animals.

本研究填补了海洋动物种群遗传学与分子生物学领域的空白。

Here, we review pioneering computational studies that have contributed to epigenetic research.

这里，我们回顾一些表观遗传学中的开创性计算学研究。

At the same time, more and more studies have suggested that epigenetic regulation may play important roles in cancer stem cell development.

与此同时，越来越多的研究表明，对于肿瘤干细胞的发生与功能维持，表观遗传学的调控机制可能发挥着极其重要的作用。

The big difference between these two alternatie ways that tumour cells use to inactiate tumour suppressor genes is that, while the reersal of genetic alterations is technically almost unfeasible in clinical scenarios, the function of these epigenetically inactiated suppressor genes is easily reactiated by pharmacological means.

这两种改变方式最大的不同之处在于肿瘤细胞利用失活的肿瘤抑制基因，而在同时相反的遗传学改变在临床方案上是很难实施的技术。

The hypermethylation of 5 CpG in promoter region serves as a mechanism of the inactivation of RASSF1A gene. This mechanism has been widely confirmed in multiple tumorgenesis including prostate carcinoma cell line DU145. Object Our study is to disclose the epigenic mechanism of the carcinogenesis of prostate cancer. Including: 1. We use demethylation agents in combination with chemotherapeutic drugs, to disclose whether demethylation agents can enhance the anticancer effect of chemotherapeutic drugs. 2. to study whether demethylation drugs can affect the methylation level of RASSF1A gene in.

目的 本研究旨在探讨前列腺癌的表遗传学发生发展机制，包括： 1、甲基化抑制剂与多种化疗药物联合应用，探讨二者间的协同作用，增强化疗药物疗效； 2、体外应用甲基化抑制剂对前列腺癌细胞DU145的RASSF1A基因甲基化水平的影响； 3、体外应用甲基化抑制剂对前列腺癌细胞DU145的RASSF1A基因及蛋白表达的影响，以期为进一步深入探索通过改变抑癌基因的甲基化而为前列腺癌发生机制和基因治疗提供有意义的数据和理论依据。

Both of these two genes were cloned into Escherichia coli for overexpression.

在生化测定的同时，我们又应用遗传学方法构建突变株分析基因功能。

Thermoanaerobacter tengcongensis is a rod-shaped, Gram-negative, anaerobic eubacterium that was isolated from a fresh water hot spring in Tengchong, China. Using a"whole-genome-shotgun"method, we sequenced its 2, 689, 445-bp genome from an isolate, MB4〓(Genbank Accession Number AE008691). The genome encodes 2, 588 predicted coding sequences . Among them, 1, 764 (68. 2％) are classified according to homology to other documented proteins, and the rest, 824 CDS (31. 8％), are functionally unknown. One of the interesting features of the T. tengcongensis genome is that 86. 7％ of its genes are encoded on the leading strand of DNA replication.

中文题名腾冲嗜热厌氧菌全基因组测序及分析副题名外文题名 A complete sequence of the T.tengcongensis genome 论文作者包其郁导师杨焕明研究员学科专业遗传学研究领域\研究方向学位级别博士学位授予单位中国科学院遗传与发育生物学研究所学位授予日期2002 论文页码总数88页关键词腾冲嗜热厌氧菌基因组嗜热菌馆藏号BSLW /2003 /Q939.1 /33 腾冲嗜热厌氧菌（MB4＇）是分离于我国腾冲地区温泉内的革兰氏阴性厌氧真细菌。

This results, combining pathological, evolutionally biological and genetic evidences, suggested it was possible that foreign transposable elements exist widely both in prokaryotes and in eukaryotes.

并且结合许多病理学、进化生物学及其遗传学的证据对异源转座子在原核和真核生物中广泛存在的可能性进行了讨论。

The cytogenetic toxic effects of different concentration of As2O3 within different time on the cell of Vicia Faba root tip were studied.

本文以蚕豆根尖为材料，研究不同浓度As2O3在不同的处理时间内对蚕豆胚根根尖的细胞遗传学毒性效应。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。