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Age, sex, activity, genetic phenotype, stress, disease (eg, achlorhydria, malabsorption syndromes), or previous GI surgery can affect drug bioavailability.

年龄、性别、活动情况、遗传表型、应激、疾病(如胃酸缺乏,营养不良综合征)或既往胃肠手术等均能影响药物的生物利用度。

Age, sex, activity, genetic phenotype, stre , disease (eg, achlorhydria, mala orption syndromes), or previous GI surgery can affect drug bioavailability.

年龄、性别、活动情况、遗传表型、应激、疾病(如胃酸缺乏,营养不良综合征)或既往胃肠手术等均能影响药物的生物利用度。

To investigate the genetic polymorphism of nine short tandem repeat loci in Han population of Southern China. The 9 STR loci (D11S2368, D12S391, D13S325, D18S1364, D22-GATA198B05, D6S1043, D2S1772, D7S3048, D8S1132) were amplified with STR_Typer_10_v1 kit for 1619 unrelated individuals of Han population in Southern China. The PCR products were analyzed with 3100 genetic analyzer and GeneMapper ID 3.1v software. The forensic efficiency parameters were calculated by PowerState V12.xls and the Hardy-Weinberg equilibrium was tested with Arlequin 3.11v software.

用STR_Typer_10_v1荧光标记试剂盒,对1 619例中国南方汉族无关个体的9个STR基因座(D11S2368,D12S391,D13S325 D18S1364,D22-GATA198B05,D6S1043,D2S1772,D7S3048,D8S1132)进行扩增,用AB公司3100遗传分析仪和GeneMapper 3.1v软件作STR分型,用PowerState V12.xls分析软件进行等位基因频率和法医学常用参数统计分析,用Arlequin 3.11v软件包作Hardy-Weinberg equilibrium平衡检验。

Its alterations of phenotype and structure have been further studied at whole, organic and cellular levels. By means of backcross between wildtype and the mutant, its genetic background has been analyzed.

本文在整体水平、组织水平和细胞水平上深入研究了该突变体的表型和结构的变化、通过突变体与野生型之间的杂交对其遗传背景进行了分析,并运用分子生物学手段对突变体相关基因进行了克隆和定位,初步探讨了该基因的表达模式和功能。

MGD stries to proide a comprehensie knowledgebase about the mouse with experiments and data annotated from both literature and online sources.

MGD提交公认的和实验的数据,代表鼠的遗传信息、基因型和表型信息,包括基因和基因产物的详细报告。

The authors proposed that heterochromatin change in genome might play an important role in balancing the germplasms between maize and its distant relatve after cross and parthenocarpy.

这种变异不仅存在于表型不稳定的早代孤雌系中,而且还存在于表型稳定的高代系中,造成这种变异的原因可能是因为远缘种质的引入影响到遗传平衡进而引起染色体发生结构重排并引起染色质的变化,这种变化与玉米染色体组中非同源染色体间存在的同源片段和因此造成的减数分裂过程中非同源染色体配对有着直接的关系。

The phenotype values of the major gene and polygene mixed inheritance of quantitative trait demonstrate multimodality, showing the mixture of more than one normal distributions, that is corresponding to more than one major gene genotypes, so the selection is different from common quantitative trait in model hypothesis and analysis.

主基因-多基因混合遗传的数量性状,其表型值呈现多峰性,表现为多个正态分布的混合,即对应多个主基因基因型,其选择与普通数量性状的选择在模型假定以及分析上都有很大的不同。

Solenopsis invicta Buren, the red imported fire ant, was first found in Taiwan in October 2003. It has two social forms, monogyne in which a colony has a single queen, and polygyne in which a colony has multiple egg-laying queens.

入侵红火蚁於2003 年10月在台湾被发现,它的群落具有两种社会型:单蚁后(monogyne, M)与多蚁后(polygyne, P);而不同的社会型在生态、生理、行为甚至遗传方面都有相当显著的差异。

Methods The method of PCR- RFLP was conducted to examine the genotype of 3 cPLA2 genes ( PLA2G4A, PLA2G4B and PLA2G4C genes) in 263 subjects, including 121 cases of T2DM and 142 controls. The conditional test was used to test the combined effect of distinct loci on the T2DM by conditioning on allele or by conditioning on genotype with UNPHASED analysis platform. Results The genotypic frequencies of the 3 genes did not deviate from Hardy-weinberg equilibrium in both case and control groups.

采用聚合酶链反应-限制性内切酶片段长度多态性方法检测T2DM患者(病例组121例)和健康对照(对照组142例)3个cPLA2基因(PLA2G4A、PLA2G4B和PLA2G4C基因)的基因型;借助UNPHASED分析平台,利用等位基因条件分析和基因型条件分析方法分析基因的联合作用与T2DM的遗传相关性。

R. Del Prato : Yeah you are right; there is a strong genetic background for type 2 diabetes although there is no major very strong genes in confirming the risk.

el Prato教授:尽管没有很强的基因可以确定2型糖尿病的风险,但是2型糖尿病有很强的遗传背景。

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