遗传型

Objective To explore the parents phenotypes in women with polycystic ovary syndrome.

目的 探讨多囊卵巢综合征患者父母亲的遗传表型。

Positive and Negative Syndrome Scale , Global Assessment of Function Scale , Modified Overt Aggression Scale , Premorbid Schizoid and Schizotypal Trait and Premorbid Social Adjustment were used in assessment of various phenotypes in affected siblings. It was found that there were high similarities of these phenotypes in siblings with schizophrenia. The results suggested that common etiology, whether genetic or environmental factors, might existed in this pattern of family.

本研究采用阳性症状和阴性症状评定量表、功能全面评定量表、外显攻击行为量表、病前社会适应和病前分裂样分裂型特质对同胞患者进行评定，结果显示各种表现型具有较好的一致性，说明同胞对患者间具有相同的遗传、环境性家族致病因素。

Results:The intramembrane proteinic particles of cell membranes of erythrocyte as well as of muscular cells were diminished significantly in DMD.

Duchenne型肌营养不良症是一组由遗传因素所致的的X连锁隐性遗传病，越来越多的学者认为细胞膜的缺陷在本病中有重要地位。

Epigenetic effects,which were defined clearly in recent years,are most often used to denote all those somatically heritable changes in gene expression that do not involve changes in DNA sequence.

后生效应是近几年才定义清楚的一类现象，指所有那些DNA序列没有改变的基因表达后体细胞的遗传表型发生改变的现象。

RAPD analysis indicated that somatically compatible strains and strains having identical mating type factors were classified into a group firstly in a cluster dendrogram based on DNA similarity coefficient.

RAPD分析显示，体细胞亲和的菌株，交配型因子完全相同的菌株，在基于DNA相似系数的遗传相关聚类中，首先聚为小类。

Objective Machado-Joseph disease/Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder caused by an expansion of polyglutamine tract near the C-terminus of the MJD1 gene product, ataxin-3. The precise mechanism of the MJD/SCA3 pathogenesis remains unclear.

目的 马查多-约瑟夫病/脊髓小脑共济失调3型，是由 MJD1基因产物ataxin-3的C-末端的多聚谷氨酰胺发生重复扩展突变而引起的一种常染色体显性遗传的神经退行性疾病，目前它的发病机制还不清楚。

The HardyWeinberg equilibrium for genotypic distribution was estimated by the goodnessoffit test.The UNPHASED program was applied to perform the transmission disequilibrium test and the combined effect analysis of the paired SNPs.

利用拟合优度χ2检验分析等位基因和基因型分布频率是否符合哈迪-温伯格定律，应用遗传统计学软件进行2个SNPs的传递不平衡检验以及双位点联合作用分析。

To develop novel live attenuated influenza vaccine, we explored the feasibility to attenuate influenza virus by codon deoptimization of NS1. According to the codon usage bias in influenza A virus, we designed and synthesized a condon-deoptimized NS gene by substituting codons of 110 amino acids in the NS1 gene of A/Puerto Rico/8/34(H1N1) with unpreferred synonymous codons.

根据A型流感病毒密码子使用偏嗜性，选取稀有密码子对A/Puerto Rico/8/34(H1N1)病毒NS1基因内部110个氨基酸区域进行密码子同义突变改造，并全基因合成NS基因，利用反向遗传操作技术拯救出含有密码子去优化NS1基因的重组病毒。

Considerable progress has been made in our understanding of the molecular basis of Rh in the past 10 years. The bases of Rh inheritance, RH gene and its evolution, the structure and function of Rh complex, as well as nonerythroid Rh homolog, have been determined.

过去的10年间，Rh血型的研究取得了极大的进展，得到了大量分子生物学的研究资料，如Rh血型的遗传方式、RH基因及其进化过程、Rh复合体的结构与功能、红细胞外Rh相似蛋白的表达，Rh基因分型技术也进一步得到发展与改进。

In especial whether or not this advantage will keep on in the course of execution of multigeneration selection scenario.

在基因型选择具有优势的世代范围之内，所获得的额外遗传进展至少可达 10％。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。