遗传作用

Objective To study the mutagenic effect of azamethiphos active compound, then to predict its genetic risk and the possibility of potential carcinogenic effect.

目的探讨甲基吡噁磷原药的致突变性，预测其遗传危害和潜在致癌作用的可能性。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

Family and twin studies indicate that autism is one of the most strongly genetic neuropsychiatric disorders.

近年来，孤独症双生子及家系研究结果证实遗传因素在其发病中起着重要的作用。

The swainsonine mainly originated from the metabolism of Oxytropis endophyte, and its concentration was related with the nitrogen fixation of nodule, but not genetic characteristics.

棘豆中苦马豆素主要来源于内生菌的代谢产物，其含量与根瘤菌固氮作用有密切关系，而与遗传无关。

To understand the role of pharmacogenetics, pharmacokinetics and pharmacodynamic in the psychopharmacological treatment of different ethnic group.

目的： 1 、理解遗传药理学、药代动力学、药效学对不同种族人群的精神药物治疗的作用。

The research results indicated that in the genetic background of weak photo-sensitivity of flowering, photoperiodic sensitive genic male sterility and fertility restoration were controlled by two sep...

结果表明，在弱感光型遗传背景下光敏不育性及其育性恢复受两对独立的细胞核隐性主基因控制和修饰基因的作用。

Part I: Angiotension I Converting Enzyme Gene Polymorphism in Chinese Patients With Obstructive Sleep Apnea SyndromeObjective Obstructive sleep apnea syndrome is a complex, multifactorial, and polygenetic disease that is thought to result from an interaction between an underlying genetic background and several environmental factors.

第一部分：血管紧张素转化酶基因多态性与阻塞性睡眠呼吸暂停综合征阻塞性睡眠呼吸暂停综合征是一种复杂的多因素和多基因疾患，是由于潜在的遗传背景和外在因素作用的结果。

As a polygenetic inheritance disease, KED exhibits obvious familial aggregation, and genetic susceptibility accounts for 1/4 of the risk factors for KBD.

大骨节病有明显的家庭聚集性，符合环境－基因交互作用的复杂性疾病，大骨节病发病的危险因素中，遗传易感性因素约占1/4。

Hypertension is a polygenic disease, it is generally believed that the combined effects of genetic and environmental results.

高血压病是多基因的疾病，一般认为是遗传和环境综合作用的结果。

However,essential hypertension is a polygenic disease and both genetic and environmental factors play important roles in its development.

原发性高血压是一种多基因遗传病，其发病系遗传与环境因素共同作用的结果，这为高血压易感基因研究带来很大困难。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。