造血药

Can accelerate the bone marrow cell from G1 phase into S phase when we measure it's Cell cycle, it make S phase rate was increased .thus it promoted DNA synthesize and repaired. Mice irradiated at dose of 5.5 Gy gamma-irradiation showed timed-related decreases and restores in peripheral blood picture at day 1 through day 21, the counts of WBC of these group had taken drug has various degree to increase than irradiation control group in day 1. Grugs failed to protected the peripheral blood cell at lowest point, but seems promote their rescovery.9803 treated group was distinct. At 7days after mice were radiated in 3.5 Gy. we observed drug can Significantly hold back the decreased number of hematopoietic progenitors colony forming radiation induced. These findings indicated 9803 have a certain radioprotective activity against gammer irradiation in mice.

给药组的 CFU-S 数量较照射对照组明显增加，3.5Gy 照后第七天观察给药9803组对小鼠骨髓造血组细胞集落生成能力的影响，给药组的造血祖细胞集落的形成能力强于照射对照组，并且9803组明显优于523组。5.5Gy 照射引起的小鼠的外周血细胞数量的降低以 WBC 发生最早，照后24小时给药组的 WBC 数量均比照射对照组有不同程度的升高，以9803各给药组最为明显，药物未能使照射引起的外周血细胞最低值升高，而有降低的趋势，但给药对照射后期外周血象的总体恢复有较好的促进作用。7.5Gy 照射后第七天测定小鼠骨髓细胞周期的测定中发现9803具有促进骨髓细胞由 G1期进入 S 期的效应，致使 G0/G1期细胞显著减少， S 期细胞比率显著增加，这利于促进 DNA 合成修复，即促进骨髓细胞增殖，骨髓细胞 DNA 含量给药组显著高于照射对照组。

rhG-CSF is effective to treat leucopenia induced by food poisoning.

结果 rhG-CSF给药后可明显减轻中毒症状和改善造血机能。

In this topic we detected the expression level of SDF-1,CXCR4,VEGF of the above two malignant hematological tumors as well as their relations to the tumor cell"s characters of drug resistance and infiltration etc, and then elucidated the change of the microenviroment" on the occurrence and development of hematologic tumor. This topic may provide some theoretical and clinical proofs for finding out some new therapeusis to the above two malignant hematological tumors.

本课题旨在通过研究急性白血病和恶性淋巴瘤患者SDF-1、CXCR4、VEGF的表达水平及其与肿瘤细胞迁移、耐药、浸润的关系，阐明骨髓造血微环境和恶性淋巴瘤局部病变微环境的改变在上述血液肿瘤发生发展中的作用及其与血管新生的联系，为从新的角度探索白血病、淋巴瘤的治疗方法提供理论及临床依据。

However, this approach conferred the resistance to not only myelopoietic cells but also tumor cells that have invaded or metastasized into bone marrow or circulating blood for nonspecific expression of the exogenous genes.

详细骨髓造血细胞中导入耐药耐辐射基因是克服放化疗对造血系统抑制作用的有效手段，但外源基因的非特异性表达也增加了残存在血液或者侵犯至骨髓中的肿瘤细胞耐受性。

Methods Colony-forming unit of spleen, number of nucleated cells in bone marrow and spleen index were used to investigate the effect of polysaccharides at 50, 80 mg/kg from parmelia tinctorium intraperitoneal injection on hematopoietic function of mice irradiated with 137Cs γ-rays; DNA double-strand breaks were detected using alkaline single cell gel electrophoresis.

用内源性脾结节形成，骨髓有核细胞计数，脾脏指数观察石花多糖50，80 mg/kg腹腔注射对137 Csγ射线照射小鼠造血功能的影响；单细胞凝胶电泳技术检测小鼠淋巴细胞照射后的DNA双链断裂，观察给药后小鼠DNA损伤修复情况。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。