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In this study, we try to explore if MSC can regulate hematopoiesis in vitro and what effects it has.

但目前对MSC与造血调控之间的关系所知甚少。本研究的目的,是探讨MSC是否能在体外调控造血,以及如何调控造血。

No significant effects were observed at 30 Gy, but the hemopoietic organs capacity was disrupted at 50~300 Gy. The hemocyte density of the larvae irradiated at different developmental stages showed suppressed increments, and carbon-ion irradiation given to the larvae at early stages compared to the later stages had a significant suppressive effect on the hemocyte density.

结果表明 30 Gy 照射对造血器官的造血机能没有明显的影响, 50 Gy 照射能引起造血器官的机能低下, 50 ~ 300 Gy 之间没有明显的剂量依存关系;不同发育阶段幼虫的造血器官表现为随着个体的发育对重离子射线的感受性降低,雌雄间没有明显的性别差异。

Cloned leukemic cells can proliferate in quantity and accumulate in marrow and the other blood-cell forming tissues,and also infiltrate in other organs and tissues,which will inhibit the normal hemopoiesis.

白血病是一类造血干细胞的克隆性疾病,克隆的白血病细胞在骨髓和其他造血组织中大量增生积聚,并浸润其他器官和组织,而使正常造血受抑制。

Among the two oxygen condition, after high intensity training, the function of hemopoiesis is restrained.

高、低强度的模拟HiLo对骨髓造血功能产生不同程度的影响,高强度、极限强度训练骨髓造血功能相对常氧受到显著抑制;在两氧环境下,高强度运动后即刻骨髓增殖活性受抑,而极限强度运动可在一定程度上刺激骨髓造血,休息40h后,模拟HiLo出现代偿性恢复。

Hematopoietic stem cells, also known as multipotent stem cells, is present in the blood of the Organization of the original group of hematopoietic cells.

造血干细胞又称多能干细胞,是存在于造血组织中的一群原始造血细胞。

Hematopoietic stem cells known as pluripotent stem cells, present in the hematopoietic tissue in a group of primitive hematopoietic cells.

造血干细胞又称多能干细胞,是存在于造血组织中的一群原始造血细胞。

Thus gp130 is the common signal transduction molecule. Gp130 molecule expresses universally on many tissues including immune system, hemapoietic system, and nerve system. Gp130 has an essential role in the function and regulation of the above systems, especially in the development of hemapoietic system. The signal transduced by gp130 is necessary during the differentiation and proliferation of hemapoietic cells. It is evidenced that the embryo of gp130 gene-knockout mouse was dead due to a serious impediment of the development of hemapoietic system.

Gp130在人体组织细胞上广泛性表达,介导和调节机体的免疫、造血以及神经系统的生理功能,尤其是在造血系统的发育过程中,具有极其重要的作用,动物实验表明,敲除小鼠的gp130分子基因可以使其在胚胎的早期阶段产生严重的造血系统障碍,最终导致流产,由此表明在造血细胞的分化、发育和生物学行为中,gp130介导的信号是必不可少的。

Within three years following-up, 5 patients with NHL were survival, but one case of NHL died at the 2 months after auto-PBSCT, one patient suicided.

通过8例非霍奇金淋巴瘤及3例淋巴细胞白血病患者在前期化疗基础上进行造血干细胞移植,分别观察造血重建、并发症及生存期等指标,以了解造血干细胞移植对该类疾病的疗效。

Transgenic CD34+ cells in the experimental group still could generate brust forming unit-erythroid, colony-forming units granulocute/monocyte and multipotential hematopoietic progenitors; especially, CFU-GM was the main cell in hemopoietic progenitor cell.

实验组转基因CD34+细胞于12周后仍可产生造血祖细胞集落红系祖细胞、粒单系祖细胞、脐血多向造血祖细胞,所形成的造血祖细胞集落以粒单系祖细胞为主。

During the whole course, the renovation to making - blood microenvironment of the marrows influences the renewal, multiplication and differentiation by itself of the making - blood stem cells, as well as has the significance to the making-blood function of the organic rebuilding.

其中,骨髓造血微环境的修复,影响着归巢造血干/祖细胞的自我更新、增殖和分化,对于机体重建造血功能具有重要意义。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

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