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造血作用

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Objective To study angelica polysaccharides for mobilizing peripheral blood hematopoietic stem cell in BALB/c mice.

目的探讨当归多糖对小鼠外周血造血干细胞的动员作用。

Leptin activates several singal transduction pathways, can regulate ingestion and energy consumption, and enhance cell growth and hemopoiesis .It also can promote cell proliferation and differentiation, and enhance angiogenesis and regulate immunization.

瘦素通过与其受体的结合,活化细胞内多条信号转导通路,在调控摄食和能量消耗,促进细胞生长、造血等方面起重要作用,同时在促进细胞增殖分化、增加细胞侵袭性、促进血管形成和调节机体免疫等方面起作用。

Objective: To investigate the effect of tanshinone ⅡA on HL-60 and K562 cells apoptosis,and to assay the inhibition of the telome rase activities in the leukemia cell apoptosis induced by Tanshinone.

中文摘要:目的观察丹参酮ⅡA对HL60,K562细胞端粒酶活性的抑制作用和对凋亡相关基因的影响,探讨丹参酮ⅡA对造血细胞的作用机理。

Angiotensin II had stimulatory effect on erythroid progenitors invitro and this effect was mediated through its AT1 receptor.

血管紧张素Ⅱ对脐血红系造血祖细胞有优势扩增作用,且通过其表面的AT1R起作用。

The experiment confirmed the important role of SOCS-3 in erythropoietic development and provided a useful new way for production of erythroid lineage cells.

研究结果证明,SOCS-3在造血发育中有重要调控作用,而对其表达进行干涉或沉默将在规模化的红细胞诱导研究中发挥重要作用。

ConclusionAll results suggested that STF can enrich blood STF and recover the haematogenesis function of hemophthisis mice by increasing the level of IL-3 and regulating the EPO level.

结论鸡血藤总黄酮具有抗贫血作用,其作用机理可能与促进机体分泌IL-3、调节EPO水平,促进红系造血有关。

SMI had protection and therapeutic effects on leucocytopenia of mice induced by irradiation.

试验还显示,照射后四天SMI大、中剂量组小鼠骨髓有核细胞数与正常对照组无显著性差异,说明其骨髓造血功能比较活跃,提示SMI对放射性损伤所致小鼠血虚证有一定的保护和治疗作用,对于小鼠白细胞减少有较好的治疗效果。结论:SMI对小鼠放射性损伤所致血虚证有一定的保护和治疗作用。

Among its many biological activities, the major function of GM-CSF is to stimulate hematogenie stem cells prolification from silent stage to S phage, so that the stem cells can differentiate into granulocyte-macrophage cells.

有4个外显子和3个内含子,基因定位于5号染色体长臂5q21-5q32区,大多数器官均能产生GM-CSF,GM-CSF有多种生物活性,作用于多种细胞谱系,其主要作用是刺激造血祖细胞增殖即从静止期进入S期,并分化为粒细胞---单核巨噬细胞。

DS is a safe and effective pretreatment, which can mobilize HSC, but also vocate niches for transplanted HSC homing.

DS是一种安全、有效的预处理方案;DS对造血干细胞既有动员作用又有促进龛位腾出以供移植干细胞回巢的作用。

Study shows that strengthening body resistance and archaeus herbs have many effects,such as improving and adjusting immunity function,protecting bone marrow,improving haematogenesis function,raising digest and absorb function,improving substance metabolism,preventing gene mutation,inhibiting tumor cell proliferation,inducing tumor cell differentiation or apoptosis,resisting tumor invasion and metastasis,inhibiting formation of tumor vessel and activity of telomerase,etc.It's possibly the result of synergistic effect by multi-pathway and multi-target.

研究表明,扶正培本药物具有增强和调节机体免疫功能、保护骨髓及提高机体造血机能、增加消化吸收功能,改善物质代谢、阻止基因突变、抑制肿瘤细胞增殖、诱导分化、促使肿瘤细胞凋亡、抗肿瘤侵袭与转移、抑制肿瘤血管形成及肿瘤细胞端粒酶活性等多种作用,其发挥的扶正作用可能是多途径、多靶点联合协同作用的结果。

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