造血作用

It turned out that hematopoietic stem cells be immortalized by constitutive Notch1 and Delta has the function as the mitogenic regulators of hematopoietic stem cells.

研究人员将活化形式Notch受体导入造血干细胞，使其获得了细胞因子依赖性的"永生"；另外，Notch的配体Delta、Jagged具有类有丝分裂因子作用，可保持造血干细胞的自我更新能力，促进其体外增殖。

In the first step the hES cells were co-cultured with cytokines by formation of the day 5 embryoid bodies(5 d EBs).

在胚胎发育的不同阶段不同的造血微环境对造血发生发挥重要作用。

Can accelerate the bone marrow cell from G1 phase into S phase when we measure it's Cell cycle, it make S phase rate was increased .thus it promoted DNA synthesize and repaired. Mice irradiated at dose of 5.5 Gy gamma-irradiation showed timed-related decreases and restores in peripheral blood picture at day 1 through day 21, the counts of WBC of these group had taken drug has various degree to increase than irradiation control group in day 1. Grugs failed to protected the peripheral blood cell at lowest point, but seems promote their rescovery.9803 treated group was distinct. At 7days after mice were radiated in 3.5 Gy. we observed drug can Significantly hold back the decreased number of hematopoietic progenitors colony forming radiation induced. These findings indicated 9803 have a certain radioprotective activity against gammer irradiation in mice.

给药组的 CFU-S 数量较照射对照组明显增加，3.5Gy 照后第七天观察给药9803组对小鼠骨髓造血组细胞集落生成能力的影响，给药组的造血祖细胞集落的形成能力强于照射对照组，并且9803组明显优于523组。5.5Gy 照射引起的小鼠的外周血细胞数量的降低以 WBC 发生最早，照后24小时给药组的 WBC 数量均比照射对照组有不同程度的升高，以9803各给药组最为明显，药物未能使照射引起的外周血细胞最低值升高，而有降低的趋势，但给药对照射后期外周血象的总体恢复有较好的促进作用。7.5Gy 照射后第七天测定小鼠骨髓细胞周期的测定中发现9803具有促进骨髓细胞由 G1期进入 S 期的效应，致使 G0/G1期细胞显著减少， S 期细胞比率显著增加，这利于促进 DNA 合成修复，即促进骨髓细胞增殖，骨髓细胞 DNA 含量给药组显著高于照射对照组。

Haemotopoietic growth factors not only support growth of hemopoietic progenitorcells but also have important effect on hemopoiesis.

造血生长因子不仅是造血前体细胞所必需的生长因子，而且对血细胞的生长及功能有重要作用。

Functionally MSC not only exerts the crucial role of supporting hemopoiesis by participating in the formation of hematopoietic microenvironment, but also maintains its capacity for renewal and its potential of multilineage differentiation when induced properly.

MSC不仅参与构建造血微环境，发挥支持造血的作用；而且在动物出生后仍然维持一定程度的自我更新能力，以及具有分化为多种类型细胞的潜力，属于成体多能干细胞范畴。

Objective To study the role of placenta on fetal hematopoiesis during embryo ontogeny, so as to find a new source of hematopoietic stem/progenitor cells for clinical transplantation.

目的 探讨胎盘在整个胎儿时期造血中的作用，寻找造血干/祖细胞的新来源，供临床移植应用。

Thus gp130 is the common signal transduction molecule. Gp130 molecule expresses universally on many tissues including immune system, hemapoietic system, and nerve system. Gp130 has an essential role in the function and regulation of the above systems, especially in the development of hemapoietic system. The signal transduced by gp130 is necessary during the differentiation and proliferation of hemapoietic cells. It is evidenced that the embryo of gp130 gene-knockout mouse was dead due to a serious impediment of the development of hemapoietic system.

Gp130在人体组织细胞上广泛性表达，介导和调节机体的免疫、造血以及神经系统的生理功能，尤其是在造血系统的发育过程中，具有极其重要的作用，动物实验表明，敲除小鼠的gp130分子基因可以使其在胚胎的早期阶段产生严重的造血系统障碍，最终导致流产，由此表明在造血细胞的分化、发育和生物学行为中，gp130介导的信号是必不可少的。

The possible hematopoietic mechanism of colla corii asini is associated with the protection of hematopoeitic microenviroment and activation of auxiliary hemapoietic organs, liver and spleen and kidney.

该有效补血活性成分的升高红、白血球的作用机制可能与保护贫血小鼠造血微环境和造血干、祖细胞，刺激髓外造血器官相关造血细胞因子表达有关。

Furthermore, couples of molecules, including Scl, Flk1 and Runx1, are involved in formation and subsequent differentiation of the hemangioblast or hemogenic endothelium during embryonic hematopoiesis.

造血和血管内皮相关分子的表达和调控作用的研究，不仅体现了造血和内皮在发育中的密切关系，同时也加深了对造血发育调控的认识。

Objective:To explore the effect of different combination of hematopoietic cell growth factorson expanding umbilical cord blood hemopoietic cells in vitro.

目的：探讨造血细胞生长因子的不同组合对脐血CD34+造血干细胞的扩增作用。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。