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The patients achieved complete remission after induction course would enter the next grouping:the patients,aged 15-45 years, who had suitable donors and transplantation will were assigned to allogeneic stem-cell transplantation,and for the rest,they would be assigned to accept chemotherapy or autologous stem-cell transplantation randomly.CT and ASCT group both received early intensification and consolidation therapy orderly,which contained high-dose methotrexate,intermediate/high-dose cytarabine and high-dose or high-fraction cyclophosphamide,followed by ASCT or re-induction,later consolidation and maintenance chemotherapy for CT group.

符合入组条件的成人非Ph+ALL患者纳入研究,患者接受标准VDCP±L诱导治疗达到完全缓解(complete remission,CR)后进入下一阶段分组研究:年龄≤45岁,有合适供者及移植意愿者接受异基因造血干细胞移植allogeneic stem cell transplantation,Allo-SCT其余患者根据意愿分别接受自体造血干细胞移植(autologous stem cell transplantation,ASCT和化疗Chemotherapy。

That analysis reealed good congruency, with r = 0.998 for unselected HCTs and r = 0.999 for selected HCTs.

分析显示完全一致,未筛选的造血干细胞移植物的相关系数r = 0.998;筛选的造血干细胞移植物的相关系数r = 0.999。

It turned out that hematopoietic stem cells be immortalized by constitutive Notch1 and Delta has the function as the mitogenic regulators of hematopoietic stem cells.

研究人员将活化形式Notch受体导入造血干细胞,使其获得了细胞因子依赖性的"永生";另外,Notch的配体Delta、Jagged具有类有丝分裂因子作用,可保持造血干细胞的自我更新能力,促进其体外增殖。

In the first step the hES cells were co-cultured with cytokines by formation of the day 5 embryoid bodies(5 d EBs).

在胚胎发育的不同阶段不同的造血微环境对造血发生发挥重要作用。

There was no significant difference in the engraftment of hematopoietic stem cells between HBV infected group and control group.

在自体造血干细胞移植和异基因造血干细胞移植中包括HBsAg组和HBsAb组在内的HBV感染组白细胞恢复到1×109/L所需的平均天数与对照组比较均无统计学的显著差异(P>0.05),乙肝病毒感染组白细胞恢复到1×109/L所需的平均天数为(14.54±5.49)d。

The data also shows that the erythropoiesis kinetics of adult peripheral blood is rather faster than the cord blood.

实验结果亦显示,成人周边血液造血干细胞其erythropoiesis kinetic较脐带血造血干细胞得快。

Can accelerate the bone marrow cell from G1 phase into S phase when we measure it's Cell cycle, it make S phase rate was increased .thus it promoted DNA synthesize and repaired. Mice irradiated at dose of 5.5 Gy gamma-irradiation showed timed-related decreases and restores in peripheral blood picture at day 1 through day 21, the counts of WBC of these group had taken drug has various degree to increase than irradiation control group in day 1. Grugs failed to protected the peripheral blood cell at lowest point, but seems promote their rescovery.9803 treated group was distinct. At 7days after mice were radiated in 3.5 Gy. we observed drug can Significantly hold back the decreased number of hematopoietic progenitors colony forming radiation induced. These findings indicated 9803 have a certain radioprotective activity against gammer irradiation in mice.

给药组的 CFU-S 数量较照射对照组明显增加,3.5Gy 照后第七天观察给药9803组对小鼠骨髓造血组细胞集落生成能力的影响,给药组的造血祖细胞集落的形成能力强于照射对照组,并且9803组明显优于523组。5.5Gy 照射引起的小鼠的外周血细胞数量的降低以 WBC 发生最早,照后24小时给药组的 WBC 数量均比照射对照组有不同程度的升高,以9803各给药组最为明显,药物未能使照射引起的外周血细胞最低值升高,而有降低的趋势,但给药对照射后期外周血象的总体恢复有较好的促进作用。7.5Gy 照射后第七天测定小鼠骨髓细胞周期的测定中发现9803具有促进骨髓细胞由 G1期进入 S 期的效应,致使 G0/G1期细胞显著减少, S 期细胞比率显著增加,这利于促进 DNA 合成修复,即促进骨髓细胞增殖,骨髓细胞 DNA 含量给药组显著高于照射对照组。

As a traditionally hematopoietic factor,Erythropoietin has other important biologic effects besides hematogenesis.

促红细胞生成素作为一种传统意义上的造血生长因子,有着造血作用以外的重要生物学作用。

During the whole course, the renovation to making - blood microenvironment of the marrows influences the renewal, multiplication and differentiation by itself of the making - blood stem cells, as well as has the significance to the making-blood function of the organic rebuilding.

其中,骨髓造血微环境的修复,影响着归巢造血干/祖细胞的自我更新、增殖和分化,对于机体重建造血功能具有重要意义。

Sichuan cord blood stem cells Centre Ltd is mainly engaged in cord blood collection, preparation, cryopreservation, genetic testing, clinical applications and related biotechnology development and utilization of the high-tech enterprises, under the "Sichuan cord blood stem cell bank" by the Ministry of Health Approved setting, which includes the functions of the public library and the library in two parts, the public library for the vast number of patients as a source of hematopoietic stem cell cord blood, cord blood stem cell transplantation since the body can be frozen cord blood for the needs of individuals and Family members provide services.

四川省脐血干细胞中心有限公司是主要从事脐血采集、制备、冻存,基因检测、临床应用及相关生物技术开发利用的高新技术企业,下属的&四川省脐带血造血干细胞库&由卫生部批准设置,该库的功能包括公共库和自体库两部分,公共库可为广大患者提供作为造血干细胞来源的脐血,进行脐血造血干细胞移植;自体库可为需要冻存脐血的个人及家庭成员提供服务。

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