造血

To observe the morphological characteristics and hematopoietic function of bone marrow megakaryocyte in children patients with idiopathic thrombocytopenic purpura,and to preliminary analyse the cause and mechanism of thrombocytopenia.

本研究观察特发性血小板减少性紫癫患儿骨髓巨核细胞形态与造血功能的改变，初步分析其血小板减少的发生机制。

Blood island, reticular cells and scattered CD34+ cells were found in the mesenchyme of placenta chorionic villi.

胎盘绒毛膜间质中可见到造血岛、网状细胞及散在分布的CD34+细胞。

MLL-AF4 itself is not sufficient for MSC transformation and the expression of MLL-AF4 in MSCs is compatible with a mesenchymal phenotype, suggesting a differential impact in the hematopoietic system and mesenchyme.

MLL-AF4本身对MSC的转化并不充足，而MSCs的MLL-AF4的表达与间充质干细胞基因型是相容的，表明其在造血系统和间充质系统的作用是不同的。

Mesenchymal stem cell, originating from mesoblast, resides mainly in post-natal bone marrow as well as human umbilical cord blood, and coexists with hematopoietic stem cell.

间充质干细胞起源于中胚层，主要位于成体骨髓和人胎儿脐血，与造血干细胞共存。

Classical chromosomal breakage tests in blood detected 4, but analyses on fibroblasts were necessary to diagnose 3 more patients with hematopoietic somatic mosaicism.

血液经典染色体断裂测试发现了1名，但是有必要进行成纤维细胞的分析来诊断另外3位造血细胞嵌合体患者。

Due to clinical variability and/or potential emergence of genetic reversion with hematopoietic somatic mosaicism, a straightforward Fanconi anemia diagnosis can be difficult to make, and diagnostic strategies combining different assays in addition to classical breakage tests in blood may be needed.

由于临床变异和/或潜在造血细胞嵌合体遗传回复变异的出现，一种简单的范可尼贫血的诊断将会变得复杂，并且可能需要联合不同的含量测定以及经典的血液断裂测试加以诊断。

The first stage in the process leading to such diversity is for the HSCs to become the precursor cells called multipotent progenitor cells.

导致这种多样性的步骤中，第一步就是造血干细胞发育成称为多能祖细胞的祖细胞。

METHODS Mustard-poisoned mice model was constructed by injected mustard gas 20 mgkg^(-1) subcutaneously.

Balb/c小鼠sc芥子气20mgkg^(-1)染毒，建立芥子气诱导的造血系统抑制模型。

The median percentage of erythrolineage, myeloblast of NEC and displasia were (58.3±8.0)%,(58.0±18.4)% and 66.7% respectively, that is different from typical AML. 52.4% of M6 patients transferred to RAEB/RAEBT and AMLM2 subtype in the disease progression. 11/19 cases (57.4%) achieved remission (CR 10; PR 1) after chemotherapy.

外周血分类显示85.7%患者有幼稚粒细胞和幼稚单核细胞，52.4%患者有幼稚红细胞和有核红细胞；骨髓涂片显示骨髓增生活跃或明显活跃；红系细胞占58.3±8.0%，原始粒细胞占NEC 58.0±18.4%；66.7%患者有病态造血，与典型AML不同。

The results indicated that in the FNAC smears of mediastinal tumor, neutropilic myelocyte, neutropilic metamyelocyte, neutropilic stab granulocyte and neutropilic segmented granulocyte were observed in granulocytic series; early normoblast, polychromatic normoblast and orthochromatic normoblast were observed in erythrocytic series; and granular megakaryocyte, thromocytogenic megakaryocyte, scattered platelet and matured lymphocyte also were observed. Cell morphology and distribution in different stages were are similar to that in bone marrow smear, and these cells belong to the extra-medullary hemopoietic tissue.

结果表明：纵隔肿块的细针抽吸活组织的细胞学涂片显示粒系细胞中可见中性中幼粒细胞、中性晚幼粒细胞、中性杆状粒细胞、中性分叶核粒细胞；红系细胞中可见早幼红细胞、中幼红细胞、晚幼红细胞；并可见颗粒巨核细胞、产血小板的巨核细胞、散在血小板及成熟淋巴细胞；细胞形态及各期细胞分布与骨髓片相似，为髓外造血组织。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。