造血

Objective: To study the effects of ABO-incompatibility on the hematopoietic reconstitution, particularly the erythropoiesis reconstitution, in HLA-matched allogeneic hematopoietic stem cell transplantation.

目的：探讨ABO血型不合对异基因造血干细胞移植患者造血重建，特别是红系造血重建的影响。

In this study, we try to explore if MSC can regulate hematopoiesis in vitro and what effects it has.

但目前对MSC与造血调控之间的关系所知甚少。本研究的目的，是探讨MSC是否能在体外调控造血，以及如何调控造血。

No significant effects were observed at 30 Gy, but the hemopoietic organs capacity was disrupted at 50~300 Gy. The hemocyte density of the larvae irradiated at different developmental stages showed suppressed increments, and carbon-ion irradiation given to the larvae at early stages compared to the later stages had a significant suppressive effect on the hemocyte density.

结果表明 30 Gy 照射对造血器官的造血机能没有明显的影响， 50 Gy 照射能引起造血器官的机能低下， 50 ～ 300 Gy 之间没有明显的剂量依存关系；不同发育阶段幼虫的造血器官表现为随着个体的发育对重离子射线的感受性降低，雌雄间没有明显的性别差异。

The recovery of hemopoiesis perhaps is increase of ability of surviving hemopoietic tissue , but is not recovery for all of bone marrow to patients with aplastic anemia.

雄激素治疗有效的病例其造血功能的恢复可能是残存造血岛的代偿性造血功能增加的结果，而非骨髓造血的普遍恢复。

Cloned leukemic cells can proliferate in quantity and accumulate in marrow and the other blood-cell forming tissues,and also infiltrate in other organs and tissues,which will inhibit the normal hemopoiesis.

白血病是一类造血干细胞的克隆性疾病，克隆的白血病细胞在骨髓和其他造血组织中大量增生积聚，并浸润其他器官和组织，而使正常造血受抑制。

By retrovirus vector the foreign mdr1 gene could be efficiently transferred into bone marrow mononuclear cells of mouse in vitro, and it was confirmed that mdr1 gene was expressing stably and effectively in cells; in short terms there is no significant influence on the bone marrow MNC by transfection of mdr1 gene,but in the long run(in our study we had surveyed 2 months),there is a decline in the expression of apoptosis factor Bax in the MNC which transfected by mdr1 gene,in favour of the recovery of the receptor mouse;on the other hand it also poses a blance problem between multiplication and apoptosis in the process of receptor hematopoiesis after transplanting HSC which was transfected with mdr1 gene.

通过逆转录病毒载体可在体外将外源性mdr1基因转入小鼠骨髓单个核细胞中，转染的mdr1基因能整合到骨髓单个核细胞基因组中并有功能性表达；mdr1基因转入小鼠骨髓单个核细胞在移植后短期内对受体造血细胞没有显著影响，但从长期看来(本研究观察2个月)转染了mdr1基因的造血干细胞的凋亡因子Bax表达降低，更有利于受体鼠造血的恢复；另一个方面它也同时提出一个问题，即mdr1基因转染造血干细胞在回输受体后造血过程的增殖凋亡平衡。

Thus gp130 is the common signal transduction molecule. Gp130 molecule expresses universally on many tissues including immune system, hemapoietic system, and nerve system. Gp130 has an essential role in the function and regulation of the above systems, especially in the development of hemapoietic system. The signal transduced by gp130 is necessary during the differentiation and proliferation of hemapoietic cells. It is evidenced that the embryo of gp130 gene-knockout mouse was dead due to a serious impediment of the development of hemapoietic system.

Gp130在人体组织细胞上广泛性表达，介导和调节机体的免疫、造血以及神经系统的生理功能，尤其是在造血系统的发育过程中，具有极其重要的作用，动物实验表明，敲除小鼠的gp130分子基因可以使其在胚胎的早期阶段产生严重的造血系统障碍，最终导致流产，由此表明在造血细胞的分化、发育和生物学行为中，gp130介导的信号是必不可少的。

The possible hematopoietic mechanism of colla corii asini is associated with the protection of hematopoeitic microenviroment and activation of auxiliary hemapoietic organs, liver and spleen and kidney.

该有效补血活性成分的升高红、白血球的作用机制可能与保护贫血小鼠造血微环境和造血干、祖细胞，刺激髓外造血器官相关造血细胞因子表达有关。

TSPG has the similar effect as HGFs, can directly or/and indirected effect and regulate proliferation and differentiation of CD34〓 HSC/HPC to bring into full play in"invigorating qi"of Panax ginseng. 2. During the process of the extensive proliferation, orderly differentiation, functional activation and gene transfer of hematopoietic stem/progenitor cells in ex vivo culture systems, TSPG may be used to regulate the proliferation and differentiation of hematopoietic cells to perform potential application in the domain of hematpoietic stem cell engineering.

我们的研究结果提示：1、TSPG具有类似造血生长因子的功效，能直接或间接影响和调控造血干/祖细胞的增殖与分化，促进血细胞的生成，从而发挥人参&补气生血&之功效。2、在进行对造血干/祖细胞的扩增与诱导分化，功能激活，基因转染等造血干细胞工程研究中可利用人参皂甙的药理作用来调控细胞的增殖分化，发挥其在造血干细胞工程领域的潜在应用价值。

The hematopoietic system was reconstituted and the chimaeras were formed.The results showed that hematopoietic stem cells coming from ES-D3 cells could reconstitute the mice following high dose chemotherapy in vivo. This research offers theories for HSCs induced from embryonic stem cells supporting the high dose chemotherapy of cancer.

将鉴定的造血干细胞移植入大剂量化疗的C57BL/6鼠，观察造血重建功能并证明有嵌合体形成，从体内实验方面证实了ES-D3细胞来源的造血干/祖细胞移植能够重建接受大剂量化疗小鼠的造血功能，为胚胎干细胞来源的造血干细胞支持大剂量化疗提供了实验依据。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了