通路

Similar as in major thalamocortical visual pathway, short-term synaptic depression was also prominent in extrageniculate pathway.

与丘脑皮层主要视觉通路相似，膝体外通路也具有显著的短时程突触抑制特性。

The results suggest that there is prominent short-term synaptic depression in the rat thalamocortical visual pathway. Presynaptic transmitter depletion and postsynaptic GABAergic inhibition are the main possible mechanisms of this synaptic depression. The short-term synaptic depression is helpful in neuronal correlated firing detection.

以上结果表明：丘脑皮层视觉通路具有显著的短时程突触抑制特性，突触前的递质耗竭和突触后的GABA能抑制系统很可能是产生视通路短时程突触抑制作用的主要机制，突触抑制作用有助于视觉系统对同步发放活动的检测。

The results suggested that vascular remodeling was the most prominent in LCA subjected to low shear stress accompanied by hypertension, which is regulated through the changing expression of p-Akt, p-p38, Rho GDIα. Tributyrin could affect the flow mediated carotid remodeling by both increasing apoptosis and decreasing proliferation of VSMCs through PI-3K/Akt, bcl-2, p53, p27. Tributyrin could have potential roles in treatment of vascular diseases, such as artherosclerosis and vascular restenosis, etc.

结果提示，高血压与切应力协同作用对血管重建的影响最为显著，Akt、p38和Rho GDIα信号通路参与了高血压与低切应力诱导的血管重建过程；Tributyrin对血管重建的干预作用是通过影响PI-3K信号通路，调节凋亡相关蛋白bcl-2以及细胞周期调控蛋白p53和p27的表达水平而实现的；Tributyrin有可能成为一种在动脉粥样硬化、血管再狭窄等疾病防治中有潜在临床应用价值的药物。

Furthermore, the network was searched for interactions linking uncharacterized gene products and human disease proteins to regulatory cellular pathways. Two novel Axin-1 interactions were validated experimentally, characterizing ANP32A and CRMP1 as modulators of Wnt signaling.

作者们进一步分析了这个网络里面未知功能的蛋白和跟疾病相关蛋白与细胞调控通路的关系，发现了两个新的Axin-1相互作用并被实验证实，及ANP32A and CRMP1在Wnt信号通路里的调控作用。

Our researches include:To establish the rat experimental model of VILI and study the the activation of the receptor of cellular membrane in VILI;To observe the change of transmembrane signal transduction and inflammation cytokine after applying the specific blocking agent of receptors;To observe the change of transmembrane signal transduction and inflammtion cytoking after applying the no specific blocking agent of receptors.

主要内容建立大鼠VILI实验模型，观察各种细胞膜受体（包括整合素受体、生长因子受体、G蛋白偶联受体）及其配体在大潮气量机械通气时的表达变化；应用各种受体的特异性阻断剂，观察对大鼠VILI信号转导通路以及炎症因子表达的影响；应用各种非特异性阻断剂，观察对大鼠VILI信号转导通路以及炎症因子表达的影响。

The method of determining the paths based on backdating method according to the network is given,and the method of computing the path reliability is proposed.

针对该网络给出了基于回溯法的通路确定方法，进而给出了通路可靠性的计算方法。

In 1922, State Farm was formed by George Mecherle, a farmer from Merna, Illinois, who aimed to take advantage of the pricing umbrella maintained by the high-cost giants of the industry. State Farm employed a "captive" agency force, a system keeping its acquisition costs lower than those incurred by the bureau insurers (whose "independent" agents successfully played off one company against another). With its low-cost structure, State Farm eventually captured about 25% of the personal lines business, far outdistancing its once-mighty competitors. Allstate, formed in 1931, put a similar distribution system into place and soon became the runner-up in personal lines to State Farm.

1922年州农保险由伊利诺州 Merna 的农夫 George Mecherle 所创立，年州农保险由伊利诺州所创立，目标锁定在打破业界掮客所树立的高价保护伞，州农雇用专属仲介人员，标锁定在打破业界掮客所树立的高价保护伞，州农雇用专属仲介人员，这套系统让州农取得保单的成本远低于一般保险同业，套系统让州农取得保单的成本远低于一般保险同业，其独立业务代表接二连三成功地搞倒其它业者，拜其低成本结构所赐，州农最终拮取连三成功地搞倒其它业者，拜其低成本结构所赐，州农最终拮取25%的个的个人业务大饼，含车险及住宅险在内，远远超越昔日强大的竞争对手，人业务大饼，含车险及住宅险在内，远远超越昔日强大的竞争对手，而创立于1931年的 Allstate 也仿效设立类似的行销通路，并一举跃居第二，立于年的也仿效设立类似的行销通路，并一举跃居第二，仅次于州农，资本主义再度发挥神奇的效用，仅次于州农，资本主义再度发挥神奇的效用，而这种低成本的营运确已势不可挡。

Then we take the two channel type (on-line channel and traditional channel) to be permuted as eight channel combination.

并以实体、虚拟两种通路在此六个阶段中进行组合，产生八种通路组合。

Furthermore, Oridonin activates retinoic acid and cAMP/PKA signal pathways and potentiates differentiation induced by ATRA and G-CSF in t(8;21) positive cells.

在细胞水平，冬凌草甲素可以在很短的时间内激活AML1-ETO阳性细胞的cAMP/PKA通路及维甲酸信号通路，增强全反式维甲酸和粒细胞集落刺激因子引起的促细胞分化作用。

Janus protein tyrosine kinase-signal transducer and activator of transcription signaling pathway may be one of the most important signaling pathway to control the biological states of thrombi.

Jak蛋白酪氨酸激酶－信号转导子和转录激活子信号通路可能是调控血栓的生物学状态的重要信号通路之一。

The reasons of iron ions content overproof in grade Ⅱ desalting water system,such as variation water quality,contamination of regenerant , operation adjustment of pretreatment system and switching operation of bed were discussed.

对二级脱盐水系统中铁离子含量超标的原因，如来水水质发生波动、再生剂受到污染、预处理系统操作调整、床体运行切换等进行了论述。

You were hired to drum up new business, so go and do it.

公司雇你招徕新业务，你就做你的事好了。