通路

Although it meant that we had to work through all the minutiae of a new language design, rather than starting from an already welldeveloped basis, it allowed us the freedom to contemplate more radical approaches to many aspects of the language design.

尽管这意味著我们不得不作出新语言设计的每一个细枝末节，而不是从一个发展良好的基础上开始，但这样给予了我们自由来忖思语言设计许多方面更激进的通路。

The brain cells that control movement are formed into pathways,like telephone wires,which cross over one another to the body.

那听起来像是一个mixde-up系统但是，通过交叉通路让两边的大脑分享信息，他们需要使双方的身体一起工作。

The RhoA oncogene , have been revealed in recent years, are closely related to various malignant tumours. RhoA, belonging to Rho family, is one member of the ras superfamily, whose encoding production, namely RhoA protein, pertaining to micromolecular mass GTP conjugated protein family, in GTP conjunctive active form and GDP conjunctive unreactive form. It exist in the latter form in normal cells and the switch of the two forms enables them to educe functions, paralleling"molecular switch", the diminutive G protein in activated state being able to activate the wink dromo-iter to work functions, which is in the resemblance of process during which the Ras genic mutation induces its continous activations.

RhoA是近年来新发现的与多种恶性肿瘤密切相关的癌基因，RhoA属于Rho亚家族，是ras基因超家族的一员，其编码产物RhoA蛋白属于小分子量GTP结合蛋白族，分为GTP结合的活性型和GDP结合的非活性型两类，在正常细胞内以GDP结合的非活性型存在，两种活性形式之间的转换使他们能够发挥一种类似&分子开关&的作用，活性态的小G蛋白能激活下游的信号传导通路，行使其功能。

Recent investigations have gradually elucidated the function of retinoids and their signaling pathways,as well as the reason resulting in failure of secondary chemoprophylaxis,This article reviews the progress of retinal receptor about its effect on lung carcinogenesis.

最新研究逐渐阐明了类视黄醇的功能、信号通路及早期化学预防失败的原因。本文将阐述视黄醇受体在肺癌变方面作用的基本和最新的认识。

Topol L, Jiang X, Choi H, et al. Wnt5a inhibits the canonical Wnt pathway by promoting GSK3 independent catenin degradation ［J］. J Cell Biol, 2003,162:899-908.［2］ Olson DJ, Oshimura M, Otte AP, et al.

Wnt5A基因被认为是评价皮肤黑素瘤侵袭能力的重要指标［10］，并且进一步的研究显示： Wnt5A介导的Wnt/Ca2+信号通路主要通过激活蛋白激酶C增强黑素瘤的侵袭力［11］。

In control cubicle no access for Aux.

在控制小卧室没有 Aux 的通路方面。

Western blot showed that increased TGF-β1, p-Smad2/3 and phosphorylation of P-38 MAPK proteines in DCM were repressed with treatment of astragaloside, while Smad7 showed no evident variations. Collagen I, the target gene of TGF-β1/Smad and TGF-β1/p38MAPK signal transduction pathway, was cut down in group Astr.

蛋白定量检测结果显示：黄芪甲甙降低TGF-β1、p-Smad2/3及Smad4的表达，以Smad4表达降低最明显，对Smad7的表达无明显作用；抑制p38MAPK的磷酸化活动；Ⅰ型胶原是TGF-β1/Smad和TGF-β1/p38MAPK信号通路的靶基因，黄芪甲甙明显降低Ⅰ型胶原mRNA的表达。

We hypothesized that in vivo inhibition of p38 MAPK in mice bearing allogeneic aortic allografts would prevent CAV.

因此我们提出假设在行主动脉移植的小鼠体内抑制p38MAPK通路能够防止CAV的发生。p38MAPK是一种信号分子，与细胞分化、凋亡以及细胞死亡相关。

Studies in neuropsychopharmacology and molecular neurobiology indicate that neurotransmitters and its receptors play important roles in alcohol abuse and addiction, and post-receptor signal transduction pathways, including cyclic adenosine 3', 5'-monophosphate-protein kinase A, phosphoinositide, Ca(superscript 2+)-calmodulin, phospholipase D and tyrosine kinase Fyn signaling cascade.

神经精神药理学和神经分子生物学研究表明，酒精滥用和成瘾不仅与中枢神经系统的神经递质及其相关的受体有关，而且，受体后的信号转导通路参与了酒精依赖的形成过程。其中包括环磷酸腺苷-蛋白激酶A、磷脂酰肌醇、Ca(上标 2+)-钙调蛋白、磷脂酶D以及酪氨酸激酶Fyn等信号途径。

Studies have shown that endonuclease Gand apoptosis-inducing factor,as mitochondrial dysfunction downstream molecules,were involved in caspase-independent cell death pathway.

研究表明，Endo G和AIF作为线粒体功能障碍的下游分子，同样参与了caspase非依赖性细胞死亡通路。

Shop assistant: Please check at the door.

店员：请您到门口柜台交费。

In the end, transportation of PAHs in the environmental matrix was preliminarily investigated and discussed according to PAHs data of soils and sediments from a certain region in Shanghai. The result indicated that there are two or more pathways on PAHs transportation in the environmental matrix.

最后，对上海特定地区内PAHs在环境介质中的迁移径途进行了分析讨论，结果表明上海市土壤和沉积物等环境介质中PAHs的迁移存在多种途径。