通路

Its absence perturbs the balance between actiation of the JAK–STAT and SHP-2–ERK-1/2–MAPK pathways, resulting in less self-renewal and a greater potential for differentiation into the primitie endoderm lineage.

SOCS-3的缺乏破坏了激活JAK–STAT和SHP-2–ERK-1/2–MAPK信号转导通路之间的平衡，这就导致了较少的自我更新，而是较强的分化成原始内胚层谱系的潜能。

Its absence perturbs the balance between actiation of the JAK-STAT and SHP-2-ERK-1/2-MAPK pathways, resulting in less self-renewal and a greater potential for differentiation into the primitie endoderm lineage.

它的缺乏干扰了JAK-STAT和SHP-2-ERK-1/2-MAPK 通路之间的平衡，最终导致自我更新能力减弱和更易于向原始内胚层分化。

Insufficient energy metabolism is a potentially reversible biomarker in the early stage of sporadic Alzheiner's disease. it may associate with abnormal insulin receptor dysfunction in the brain. The decrease production of energy substrates in astrocytes potentiates oxidative stress in the neurons.

能量代谢减退是散发型阿尔茨海默病早期可逆性标志，可能与脑内胰岛素受体信号传导通路异常有关，星型细胞能量底物生成减少，神经细胞氧应激增加。

In the first part,we carried out the study of the predisposing genes related to the NMDAR-LTP pathway.

第一方面的工作是在依赖NMDAR的LTP通路上进行精神分裂症易感基因的研究。

Objective To investigate the relationship of Wnt signaling pathway and E-cadherin/catenins as well as their roles in the invasion and metastasis of gastric carcinoma in order to provide valuable molecule marker to clinical diagnoses and prognoses.

目的 探讨胃癌中Wnt信号通路与E-cadherin/catenins复合体的关联性及其与胃癌浸润转移的关系，为指导临床治疗与判断预后提供有价值的分子指标。

Various DNA repair pathways exist: one group of mechanisms rectifies errors in the DNA sequence, another group checks the integrity of the chromosomes.

各种修复通路存在：一组机制，纠正错误的基因序列，另一组检查了完整的染色体。

What is making the pathway blocked and how do you clear it for easy redoing my icons if they continue to disappear?

是什麼使通路阻塞，你如何清除它便於重做我的图标，如果他们继续消失？

However, this is the first discovery that GAPDH actively regulates the insulin pathway.

然而，这是首次发现GAPDH能积极的调节胰岛素通路。

9 Rooks – Put them on open files, half-open files, files that are likely to be opened, or behind advanced passed pawns.

把车放在通畅的线上，或是半通畅的线上，或是放在那些有可能被开通的线上，或是放在向前推进的通路兵后面。

In vivo, CXCR4-A549 and A549 cells were injected subcutaneously into nude mice(each group in 6).Four weeks later the mice were scarified and the tumors in situ and the lungs were taken out to be examined histologically.(3) Th cell cycle distribution was measured by flow cytometry to analyse the effect of SDF-1/CXCR4 in the cell proliferation and atoposis. The changes of the intracellular calcium concentration after SDF-1 activation were aslo measured by flow cytometry. Western blot was used to anlayse the phosphorylation of AKT and ERK, and the expression of MMP-2 and VEGF-C.

3为探讨SDF-1/CXCR4在肺癌侵袭和转移中的作用机制：①利用流式细胞仪检测CXCR4-A549与A549两组细胞的增殖和凋亡，分析上调CXCR4的表达后，对细胞生长周期的影响；②利用流式细胞仪检测两组细胞钙离子内流强度，分析SDF-1/CXCR4对钙离子通道活性的调控；③采用Western blot实验检测两组细胞PI3K/AKT、MAPK/ERK相关信号通路的活性，分析SDF-1/CXCR4可能激活的下游信号分子；④采用Western blot和RT-PCR检测两组细胞肿瘤转移相关基因VEGF-C、MMP-2的表达，探讨SDF-1/CXCR4与VEGF-C、MMP-2的相互作用关系。

What would he tell Judith and the children?

他将怎样告诉朱迪丝和孩子们呢？

I this is at that time, the opinion with peacockish true girl is full of in a heart.

这就是当时的我，一个心中布满虚荣的女孩子真实的想法。