通路

The researchers conclude that the absence of functional Tyk2 caused the defects in the multiple cytokine signals that were observed in the patient and identify human Tyk2 mutation as a unique type of primary immunodeficiency with characteristics similar to autosomal recessive HIES.

研究人员总结到，Tyk2功能缺失会导致多种细胞因子信号通路发生缺陷，就像在人类HIES患者中观察到的一样；人类Tyk2突变作为原发性免疫缺陷的一种类型，特征与常染色体隐性HIES相似。

Take SYBR Green I as the intercalating fluorescence dye in Real-time PCR,the overexpression of WIPK and SIPK,which were the key genes of MAPK cascades,and the resistant gene PR1 in tobacco treated with copper and magnesium solution were studied.

采用SYBR GreenⅠ作为荧光染料的Real-time PCR方法，明确了铜、镁素能调控烟株体内蛋白激酶级联信号转导途径的关键基因WIPK、SIPK及抗病信号通路末端PR1基因的过量表达，进一步揭示了矿质营养调控烟草对病毒抗病性的分子机制。

Research progress of anti-tumor mechanisms of ginsenoside Rh2（G-Rh2） extracted from ginseng was expounded,and the anti-tumor activity and mechanisms of G-Rh2 were discussed on regula-ting signal access system of tumor cells,reversing abnormal differentiation and tolerance of tumor cells,reducing telomerase activity of tumor cells,strengthening immunological ability,improving anti-tumor ability ,and interdicting synthesis and metabolism of tumor cellular important components etc.

论述了从人参中提取的有效成分人参皂苷-Rh2（G-Rh2）的抗肿瘤机理的研究进展，并探讨了G-Rh2在调节肿瘤细胞信号通路系统、逆转肿瘤细胞的异常分化与耐药性、降低肿瘤细胞端粒酶活性、增强机体免疫力、提高抗肿瘤能力以及阻断肿瘤细胞某些重要成分的合成与代谢等方面的抗肿瘤活性及其作用机理。

It was found that this pathway did not involve an orthoester intermediate, as has been reported to form in other intramolecular reactions between epoxy and ester moieties.

有人认为，这通路不涉及一个酸酯中间，如据报道，在其他形式的分子内反应与环氧酯基。

Maybe you're trying to prove to your landlord that some of the more questionable members of the general East Vancouver public are using the pathway between your building and the one next door as a shortcut between streets.

也许你正在试图证明您的房东表示，一些较有问题的成员一般东温哥华公共使用的是通路之间您的建设和一隔壁作为一个捷径之间的街道上。

Confocal microscope detection experiments showed that, in morulae and blastocysts, with theincreasing concentration of BPA, embryo of cytochrome C release rate increased. This showedthat the cytochrome C involved in BPA-induced the embryos apoptosis process. This processis regulated by the mitochondrial pathway.

激光共聚焦显微镜检测细胞色素C结果显示：在桑椹胚期和囊胚期，随着BPA处理浓度的升高，释放细胞色素C的胚胎比率逐渐增加，说明细胞色素C参与了BPA诱导胚胎细胞凋亡的过程，这一过程是通过线粒体通路来调节的。

Although HP's board nixed the merger, Perez' prowling later resulted in a joint venture, established in 2000, to produce high-quality inkjet photo printers for retail outlets.

即使HP的董事会拒绝这项合并案， Perez 稍后暗中搜寻的动作结果是在2000年创立一家合资企业，帮零售通路生产高品质的喷墨相片印表。

In 1922, State Farm was formed by George Mecherle, a farmer from Merna, Illinois, who aimed to take advantage of the pricing umbrella maintained by the high-cost giants of the industry. State Farm employed a "captive" agency force, a system keeping its acquisition costs lower than those incurred by the bureau insurers (whose "independent" agents successfully played off one company against another). With its low-cost structure, State Farm eventually captured about 25% of the personal lines business, far outdistancing its once-mighty competitors. Allstate, formed in 1931, put a similar distribution system into place and soon became the runner-up in personal lines to State Farm. Capitalism had worked its magic, and these low-cost operations looked unstoppable.

1922年州农保险由伊利诺州Merna的农夫George Mecherle所创立，目标锁定在打破业界掮客所树立的高价保护伞，州农雇用专属中介人员，这套系统让州农取得保单的成本远低于一般保险同业，其独立业务代表接二连三成功地搞倒其它业者，拜其低成本结构所赐，州农最终拮取25%的个人业务大饼，含车险及住宅险在内，远远超越昔日强大的竞争对手，而创立于1931年的Allstate也仿效设立类似的行销通路，并一举跃居第二，仅次于州农，资本主义再度发挥神奇的效用，而这种低成本的营运确已势不可挡。

In 1922, State Farm was formed by George Mecherle, a farmer from Merna, Illinois, who aimed to take advantage of the pricing umbrella maintained by the high-cost giants of the industry. State Farm employed a "captive" agency force, a system keeping its acquisition costs lower than those incurred by the bureau insurers (whose "independent" agents successfully played off one company against another). With its low-cost structure, State Farm eventually captured about 25% of the personal lines business, far outdistancing its once-mighty competitors. Allstate, formed in 1931, put a similar distribution system into place and soon became the runner-up in personal lines to State Farm. Capitalism had worked its magic, and these low-cost operations looked unstoppable.

1922年州农保险由伊利诺州Merna的农夫George Mecherle所创立，目标锁定在打破业界掮客所树立的高价保护伞，州农雇用专属仲介人员，这套系统让州农取得保单的成本远低于一般保险同业，其独立业务代表接二连三成功地搞倒其它业者，拜其低成本结构所赐，州农最终拮取25%的个人业务大饼，含车险及住宅险在内，远远超越昔日强大的竞争对手，而创立于1931年的Allstate也仿效设立类似的行销通路，并一举跃居第二，仅次于州农，资本主义再度发挥神奇的效用，而这种低成本的营运确已势不可挡。

Dysfunctions of transcription factors, which are key elements in the regulation pathways, are involved in numerous pathologies.

调控通路中关键因素----转录因子的功能失调涉及到很多疾病。

What would he tell Judith and the children?

他将怎样告诉朱迪丝和孩子们呢？

I this is at that time, the opinion with peacockish true girl is full of in a heart.

这就是当时的我，一个心中布满虚荣的女孩子真实的想法。