通路

In present study, the model of the low shear stress in carotid or hypertension was established by the ligation of partial distal branches of the left common carotid or the coarctation of aorta in SD rats respectively. In some rats the low shear stress in carotid was accompanied by the hypertension. The media and intimal thickness, as well as the ratio of vessel thickness to inner diameter were determined by morphometrical approach.

本文通过腹主动脉缩窄、结扎左颈总动脉的部分分支建立了高血压、左颈总动脉低切应力、以及高血压伴有低切应力大鼠动物模型；几何形态学方法观测左颈总动脉的壁厚及壁厚/内径比的变化；金属蛋白酶谱法分析MMP-2活性；免疫印迹法检测信号通路分子p-Akt、p-38分子以及Rho GDIα的表达变化。

Thus, IDH1 appears to function as a tumor suppressor that, when mutationally inactivated, contributes to tumorigenesis in part through induction of the HIF-1 pathway.

研究者认为，IDH1具有肿瘤抑制子的作用，一旦IDH1发生突变失活则导致HIF-1通路发生改变促进肿瘤发生。

ERK1/2 MAPK pathway plays a role in myogenesis.

那么，是否ERK1/2 MAPK信号通路参与了低氧抑制成肌细胞体外分化的调控呢？

These results indicated that increasing ERK1/2 activity by forced expression of MEK1 could partially reverse the inhibition of myogenic differentiation by hypoxia.

以上结果提示，ERK1/2 MAPK信号通路可能参与了低氧抑制成肌细胞体外分化的调控。

PKA-CREB signal transduction is involved in the spatial learning and memory function of the marginal division of the rat neostriatum.

PKA-CREB信号通路参与了大鼠纹状体边缘区及海马的空间学习记忆功能。

Traditionally, methods of urinary diversion include percutaneous nephrostomy, ureterocutaneostomy, ileal conduit and uretero-sigmoidostomy.

传统性的尿道分流方式有：经皮肾脏造瘻，输尿管皮肤造口术，回肠通路或输尿管乙状结肠吻合术。

Although an actie central nerous system is present by the eighth week of deelopment and a brainstem by the end of the first trimester (which could act as a rudimentary modulator of sensory information and motor actiity), Flower noted that the neocortex does not become a functional part of the neuraxis until at least mid-gestation when the thalamus (the major gateway for sensory input to the cerebrum) makes its first afferent contacts with the neocortex.

虽然在发育8周中枢神经系统即可有活性，在妊娠前三月结束时脑干具有活性（可充当感觉信息和运动功能的未完全发育的调制器），但是Flower表示，新皮质不会成为神经轴有功能的一部分，直到至少妊娠中期，丘脑（感觉传入大脑的主要通路）发挥其首先与新皮质系统输入联系的功能。

Acupuncture "Zusanli"(ST36) right at the time of the introduction - hub - news-axis can be summed up as follows:to stimulate the adoption of a specific pathway,upload it to the brain limbic system specific functions excited nuclei,and then through the neurohumoral mechanism of the serum gastrin level in order to regulate the physiological functions of target organs.

针刺右侧足三里穴时的传入-中枢-传出轴可以概括为：刺激通过特定传导通路，上传到大脑兴奋边缘系特定功能核团，进而通过神经体液机制影响血清胃泌素水平，以此来调节靶器官的生理功能。

Recent evidence derived from the study of animal models of various neuropathological conditions, however, has revealed that damage to axons and synapses long precedes the activation of death pathways.

近来从研究神经病理性损害的模型获得的证据，已经揭示了轴突和突触的损伤大大早于死亡通路的激活。

This effect may be closely related to the up-regulation of the BDNF signal pathways of hippocampus, therefore promotion of the neural neurotrophy and plasticity.

CTN-T在大鼠慢性应激模型上具有抗抑郁作用，其作用机制可能与上调海马BDNF相关的信号传导通路活性，改善神经营养和神经可塑性有关。

What would he tell Judith and the children?

他将怎样告诉朱迪丝和孩子们呢？

I this is at that time, the opinion with peacockish true girl is full of in a heart.

这就是当时的我，一个心中布满虚荣的女孩子真实的想法。