通路

GSK-3βis now recognized as not only a key rate-limiting enzyme of glycogen metabolic process, which phosphorylats hepatic glycogen synthase and makes it devitalize by insuline regulation, but also plays an important role in at least three signal transductory systems, namely, the Wnt/wingless, PI3'-kinase and Hedgehog pathways,which influence cellular processes, such as protein synthesis, cell proliferation, cell differentiation, cell motility and apoptosis.

GSK-3β是糖原代谢过程中的重要限速酶，除了可以在胰岛素调控下磷酸化肝糖原合成酶并使之失活外，GSK-3β还在多个重要信号通路中扮演了关键角色，例如Wnt/β-catenin pathway，PI3K/AKT pathway，Hedgehog pathway，在蛋白合成、细胞增殖、细胞分化、细胞运动、细胞凋亡以及肿瘤发生等方面都扮演了重要角色。

Cells were marked with Oxidation-susceptible fluroscent probe 2,7-dichorofluoresin diacetate and were assayed by flow cytometry.

分别用不同浓度的MGO、AGE-HSA、细胞内信号传导通路抑制剂、抗氧化剂及Simvastatin作用于HPMC.1。

At the mesencephalic, diencephalic, and pontine levels, thrombosis of small veins might be accompanied by a very large, sometimes hemorrhagic lesion, since there is nearly no collateral venous pathway.

但在间脑、中脑、脑桥水平，由于几乎没有静脉侧支循环通路存在，因此一旦这些部位的小静脉受累形成血栓，就会产生较大的、甚至有时伴出血的病灶。

Dimeric structure and several signaling pathways have thus far been proved to be closely correlated with the activation of c-Kit.

迄今为止，二聚化结构及磷酯酰肌醇3′-激酶（PI3K）、JAK-STAT等十几条激酶介导的信号通路被陆续证实与c-Kit的活化密切相关，而针对抑制c-Kit活化设计的靶向药物也陆续投入应用，与特异性的单克隆抗体一起在临床相关肿瘤的诊断及治疗等方面起到了关键性的作用。

IUGR can induce the obstacle of signal transduction and effecter molecule by impacting on IRS?2,which might be one of the molecular mechanisms of IUGR with insulin resistance at adult.

宫内发育迟缓对胰岛β细胞上胰岛素信号分子胰岛素受体底物2的影响导致胰岛素信号转导通路障碍，这可能是胎儿宫内发育迟缓鼠成年后发生胰岛素抵抗的原因之一。

ABSTRACT Hairy and Enhancer-of-split-type protein 1 (Hes1) is a main effecter of the Notch pathway and acts as a differentiation repressor and/or as a pro-expansion factor during the pancreatic development.

由于人们尚未找到胰腺干细胞的特异性标志，因而给胰腺干细胞的分离纯化及其特性的研究带来了极大的困难。来自hes1-/-敲除小鼠的研究提示，Hes1作为Notch信号通路的一个关键分子，在胰腺发育过程中扮演着扩增促进因子或分化抑制因子的角色，因而有可能用作胰腺干细胞的备选标志分子，但这一推论缺乏直接的证据。

It is our first to find that H2S may up-regulate HO-1/CO in the tissue of endotoxic shock rat model.

4首次发现H2S可上调内毒素休克大鼠组织中的HO-1/CO通路。

The human engrailed homolog En2 functionally substitutes the role of ceh-16 in promoting self-renewal expansion division of seam cells.

此外，ceh- 16突变后还会影响线虫中一个多巴胺神经元的形成，作者还证明这种异常表型也是和侧线细胞的不对称分裂和Wnt信号通路有关。

E. , ACTH antagonizes the analgesia mediated byμand δ opioid receptors, but notκreceptor;(2) The antagonizing effect of ACTH on opioid analgesia is proposed to be mediated by ACTH receptors, although the latter has not been characterized;(3) A contradictory interaction on intracellular cAMP content may constitute one of the postreceptor mechanisms underlying ACTH antagonism of opioid analgesia;(4) Another proposed mechanism of the anti-opioid effect of ACTH is that ACTH can modulate opioid-induced suppression of calcium influx;(5) ACTH has been shown to induce Fos protein expression in selected areas of the rat brain including the nuclei involved in pain regulation as well as the ependyma of the third ventricle and the aqueduct.

根据以上实验结果，本论文首次提出以下论点：（1）ACTH在脊髓水平对抗阿片镇痛具有受体选择性，即ACTH可对抗μ受体和δ受体介导的镇痛，不对抗κ受体所介导的镇痛；（2）由于ACTH与阿片μ受体的肽类配体的结合位点仅有很低的亲和力，与μ受体的非肽类配体的结合位点以及δ受体无亲和力，推测ACTH是通过中枢内的ACTH受体介导发挥抗阿片效应的；（3）ACTH抗阿片作用的受体后作用机制之一是在cAMP信使通路水平与阿片发生相互作用；（4）ACTH抗阿片作用的另一受体后机制是在〓水平影响阿片的效应；（5）通过Fos蛋白的诱导揭示：ACTH可以作用于脑内多个核团，其中包括许多与痛觉调制有关的核团，推测ACTH可能通过激活这些核团的神经元而发挥其中枢效应。

Analysis of five other epigenetically repressed genes indicates that Ras directs the silencing of multiple unrelated genes through a largely common pathway.

分析另外5个表观抑制基因显示Ras通过一个主要的共有通路指导多相关基因的沉寂。

What would he tell Judith and the children?

他将怎样告诉朱迪丝和孩子们呢？

I this is at that time, the opinion with peacockish true girl is full of in a heart.

这就是当时的我，一个心中布满虚荣的女孩子真实的想法。