通路

Rats were bilaterally implanted with cannulas in the dHP or mPFC and were microinjected with U0126, a specific inhibitor of ERK upstream activator, or vehicle for 7 consecutive days.

结果表明海马ERK信号通路阻断大鼠表现了抑郁症的核心症状快感缺乏和明显的焦虑行为；前额叶皮质ERK信号通路阻断大鼠表现为快感缺乏和活动水平的降低。

METHODS: Firstly,depanding on the methods of FCM,MTT etc,we got the best density and actiontime of adriamycin.and then,we used several depressors of different signal transduction pathways to observe the possible pathway of osteosarcoma cell apoptosis.

首先通过FCM，MTT等方法探讨引起成骨肉瘤细胞凋亡的最佳药物作用浓度及时间；在此条件下应用不同信号转导通路的抑制剂观察导致细胞凋亡的可能通路；最后应用Western？？？？

Methods: firstly,depanding on the methods of fcm,mtt etc,we got the best density and actiontime of adriamycin.and then,we used several depressors of different signal transduction pathways to observe the possible pathway of osteosarcoma cell apoptosis.finally, we observed different expression including phosphorylation and non phosphorylation of correlated signal molecules,by the methods of westernblot.

首先通过fcm，mtt等方法探讨引起成骨肉瘤细胞凋亡的最佳药物作用浓度及时间；在此条件下应用不同信号转导通路的抑制剂观察导致细胞凋亡的可能通路；最后应用western blotting来检测在成骨肉瘤细胞凋亡过程中相关信号分子的表达水平及磷酸化水平的变化。

To investigate the change of mitogen activated protein kinase signaling pathway during prostate cancer progression, and therefore to explore its role on cell proliferation.

目的：研究前列腺癌进展中细胞丝裂原活化蛋白激酶信号通路的变化，探讨阻断此通路对前列腺癌细胞增殖的影响。

Furthermore continuous visitings paid to distributors, agents and dealers in each local country market provide the case company with in-depth information about establishment and operation of its global distribution channels.

另外，持续安排拜访全球各国通路商、代理商或经销商，以深入了解各国家地区间行销通路及据点布建和运作状况，俾使合作厂商之资源及策略能与个案公司之全球行销策略结合，发挥最大力量，创造最大绩效。

In vertebrate organisms,thesignaling pathway is initiated by the binding of ligandsto the membranousreceptor patchedwhich in turn alleviates the suppression on smoothened,subsequently Smo triggers a series of intracellular events with resultant activation of thezinc-finger transcription effectors,glioma-associated oncogenes(Glil,Gli2,Gli3)transcription factor,which induces the expression of numerous target genes,such as Ptch-1,Hip,Gli1 and Wnt,that regulate proliferation,differentiation.

Hedgehog信号通路是高度保守的调控胚胎组织分化发育的通路，在脊柱动物体内，Hh蛋白与跨膜受体Ptch结合后，解除了Ptch对Smo的抑制，随后Smo从共受体上解离下来进入胞浆，将信号下传并激活锌指转录因子Gli，后者启动Ptch-1、Hip、Gli1、Wnt等目的基因的表达，进而调控细胞的增殖、分化。

The Salk Institute team, led by Siler Panowski and Andrew Dillin, said the new pathway is mediated by a gene already known from its role in building the worm's gut while the worm is an embryo.

Siler Panowski和Andrew Dillin领导的索尔克学院研究团队认为，在蠕虫的胚胎期，基因就开始对这个新的通路进行调解，且该基因对通路得调节不同于对蠕虫肠道形成的调节。

The only access to the town is the bridge.

接近；进入；入口；通路到镇上唯一的通路是一座桥。

Cut off cut-off valve is mainly used for fluid pathway, including the cut-off valves, gate valves, plug valves, ball valves, butterfly valves, diaphragm valves, control API Cast Steel Valves valves and other folders; The main control valve for regulating fluid pressure, flow, etc., including control valve, throttle, valve and float valve, etc.; Check valve used to prevent reverse flow of fluid; Shunt valve fluid channel for distribution of destination, or two-phase separated, including slide valves, multi-valve, trap, and emptying valves and so on; Safety valve is mainly used for security, to prevent the boiler, pressure vessel or pipeline overpressure due to the damage; Multi-valve is a valve with more than one function, such as the cut-off valve can both start and end back from the role of the role of drying.

截断阀主要用于截断流体通路，包括眼镜阀截止阀、闸阀、旋塞阀、球阀、蝶阀、隔膜阀、夹管阀等；调节阀主要用于调节流体的压力、流量等，包括调节阀、节流阀、减压阀和浮球调节阀等；止回阀用于阻止流体的逆向流动；分流阀用于分配流体的通路去向，或将氧气专用阀、铜阀门两相流体分离，包括滑阀、多通阀、疏水阀和排空气阀等；安全阀主要用于安全保护，防止锅炉、压力容器或管道因超压而破坏；多用阀是具有一种以上功能的阀门，如截止止回阀既能起断流作用又能起止回作用。

Finally, the influence of W/L of nMOS and pMOS in the path for charge self-compensation and input of the circuits on this technology is analyzed thoroughly.

最后，系统分析了补偿通路中晶体管宽长比，电路输入矢量等多方面因素对补偿通路的影响。

The reasons of iron ions content overproof in grade Ⅱ desalting water system,such as variation water quality,contamination of regenerant , operation adjustment of pretreatment system and switching operation of bed were discussed.

对二级脱盐水系统中铁离子含量超标的原因，如来水水质发生波动、再生剂受到污染、预处理系统操作调整、床体运行切换等进行了论述。

You were hired to drum up new business, so go and do it.

公司雇你招徕新业务，你就做你的事好了。