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In conclusion, tobacco specific carcinogen, NNK, enhanced colon cancer metastasis through α7-nAChR and E-cadherin — one of the hallmarks of epithelial mesenchymal transition — and its transcription repressors, Snail and ZEB1. Besides, the nicotine also enhanced the colon cancer cell migration through non-E-cadherin pathway.

从我们的实验得知菸草中的致癌物质NNK能透过结肠癌细胞上的α7尼古丁受器而改变E-cadherin转录及其转录抑制因子(Snail和ZEB1)的表现量来增加结肠癌细胞的转移能力，而尼古丁则是透过E-cadherin以外的途径来促进结肠癌细胞转移。

This paper measured the transmittance spectrum of Sr_3NbGa_3Si_2O_(14),a new kind of piezoelectric single crystal,from ultra-violet to visible wavelength and studied its optical activity by a novel method—measuring the transmittance spectra in Z-direction between parallel polarisers. And the rotation dispersion was fitted.

本文测定了紫外、可见光区新型压电晶体—Sr3NbGa3Si2O14的透过率，并利用一种新方法即通过测量晶体在平行偏振系统中的透过率谱研究了其旋光性，且拟合出旋光色散曲线。

Gas looming through the fog in divers places in the streets, much as the sun may, from the spongy fields, be seen to loom by husbandman and ploughboy.

街道各处透过雾气隐约可见上升的烟气，就像农夫和耕童从肥沃的农田透过雾气隐约可见天上的太阳。

Can reverse JA-induced migration inhibition JA-treated cells also showed significantly higher adhesion to laminin In conclusion these results indicate a novel anti-tumor role of JA via reducing reorganization of cytoskeleton increasing integrin 3 expression and adhesion ability to inhibit tumor cells migration Furthermore immunofluorescence staining of phalloidin/actin indicated that JA-treated cells exhibited cytoskeleton rearrangement and significant decreases in the number and length of filopodia Activity of Rho-family small GTPases was detected by a GST-pull down assay and showed that GTP-loaded Cdc42 and Rac were decreased in JA-treated cells In the future we hope these findings will be helpful to further understand the mechanisms underlying tumor progression in oral cancer and subsequently improve the cancer prevention and treatment

以抗体阻断integrin ？3可以有效使OC2恢复被JA所抑制的迁移能力。细胞贴附实验指出JA能提高OC-2在laminin环境下的贴附能力。当我们进一步以免疫萤光染色观察细胞，发现在JA处理下的OC-2，其外形、细胞骨架和细胞边缘的filopodia的密度和长度明显减少，利用GST-pull down assay侦测到Cdc42-GTP和Rac-GTP的表现量降低。推论爵床素A可能透过刺激口腔癌细胞大量表现integrin ？3，使细胞贴附能力增加或是透过改变细胞骨架来降低细胞迁移能力。希望本研究对於JA所做的抗癌及抗转移效应评估能提供口腔癌治疗在研发上一些帮助。

The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase).

oestrogen 综合的抑制被最容易透过在oestrogen biosynthesis的小路抑制最后步骤取得，回应，透过在类固醇分子(因此酵的琐屑的名字，aromatase)内建立一个芳环把雄性激素转变成oestrogens。

The more practical section describes damages by viruses on trees and by bacteria on the xylem of trees and on structural timber, wood discoloration caused by molds and stain fungi, wood decays by rot fungi, and preservation methods.

更实际的部分对树和透过在树的木质部上和在架构的木材上细菌透过病毒描述损害，木头脱色以模型引起和污点菌，木头腐坏以腐烂菌和保护方法

Through analysis and discussion in the following chapters, four strategies are summarized for teachers' further reference.(1) The individualized physical education program－Through the plan with similar to IEP, teachers arrange physical activities properly for children with mental retardation.(2) Cognitive behavior modification－Through demonstration and guidance, students are able to change behaviors by modeling and correcting their cognitive patterns.(3) Task analysis approach－Teachers have to divide a particular movement skill into several individual sub-skills and then students would be able to master that specific skill by linking every well-practiced sub-skill.(4) Data processing mode－Students are motivated to learn with fun because the target skill has been analyzed into meaningful and organized procedures.

经过分析与探讨，本文提供四大体育教学策略供从事体育教学之教师参考：一、个别化体育计划——透过类似个别化教育计划（Individual Education Program， IEP）的计划，让教师先对智能障碍学童的需求与体育活动作适当的安排；二、认知行为改变技术——教师以示范、引导的方式，使智能障碍学童经由模仿，修正认知，让行为得以改变；三、工作分析法——教师先将动作技能分解成数个分项，智能障碍学童经充份练习每一分项，最后再将每个细部动作串联；四、讯息处理模式——透过教师引发学习动机，并将动作以有意义化与组织化的学习方式，让智能障碍学童从乐趣中学得动作技能。

Kansas may be soon known less for Dorothy and Toto and more for Dr. Dean Zollman and his atomic orbitals. Dr. Zollman came from Kansas State University to visit NEHS and speak to two hundred of our top-performing upper-grade science students on May 22nd. He shared with us his school掇 special teaching methods for making quantum mechanics easy to understand for all students (That掇 no small leap!).

美国堪萨斯州州立大学物理系系主任左门教授应邀来台访问，透过陈金枫老师的协助，特於五月二十二日莅临本校对高中部及双语部的同学发表有关量子力学方面的演说，左门教授的讲述透过实物操作及电脑上的虚拟实验，将此项对高科技有深远影响的量子力学概念生动的传达给同学。

The author through the creation of life, social phenomenon, observation, reflection, as well as data collection, Through the process of re-shaping of self-creation.

本创作是作者透过对生活，社会现象的观察、省思以及资料的收集，透过自我形塑的过程再创作。

Such doubts havesitimulated the researchers'curiosity and start to explore the students' terms This research proceeds by observation interview test using learning sheets and etc The purpose is to explore students' terms of scientific concepts sources of terms connections between students' usage nomenclature and chooses of usage The results of the research are as follows: 1 There are five kinds of naming principles for students' terms of scientific concepts: appearance habit function replacing and sound Appearance principle contains three categories: color shape and partial construction; habit principle contains custom and ability; replacing principle contains reality and non-reality 2 Students' terms of scientific concepts come from two ways: self-acquisition and learning through senses The former way is only a bit more common than the latter 3 There are three different relationships between students' usage of terms and nomenclature: one both the same in usage and meaning; the other both different; another different usage but the same meaning Normally terms that students used are various from nomenclature in the aspects of usage and meaning only a few would match and even rare for "Synonyms" to occur 4 Alternative options for students' scientific terms are maintenance adaptation or co-existence with formal scientific terms The most common way of selecting usage of terms is to maintain Sometimes students would adapt themselves once learn of scientist's term However some believe that very odd chances for both could exist at the same time

这样的疑问深深引起研究者的好奇，著手探索学生科学概念所使用的语言。本研究透过观察、访谈、学习单施测等方法来进行，目的在探讨学童在科学概念上所使用之学生惯用语、学生惯用语来源、学生惯用语与科学家用语之关联性、学生惯用语选择。研究结果如下：一、学童在科学概念上所使用之学生惯用语的命名原则有五种：外型、习性、功能、藉代称呼及声音，其中外型原则有颜色、体型及部份构造三类目，习性原则有习惯及能力两类目，藉代称呼原则有实体及虚拟两类目。二、学童在科学概念上所使用之学生惯用语有两种来源，分别为自己称取和听来。学生惯用语来源较多为自己称取，透过其他方式听来少一点，但两种来源的比率差距甚小。三、学童在科学概念上所使用之学生惯用语和科学家用语的关系有三种，分别为用语意涵均相同、用语不同意涵相同和用语意涵均不同。学生惯用语通常和科学家的用语是不同的，且其意涵也不同，只有部份学生惯用语和科学家用语意涵均相同，至於学生惯用语和科学家用语不同但意涵相同的极少。四、学童的科学概念相关学生惯用语选择有三种，分别为维持学生惯用语、改变成科学家用语和科学家与学生惯用语皆可。学童的科学概念相关学生惯用语选择，以维持学生惯用语最多，而有些时候学生会在得知科学家的用语后改变成科学家用语，但认为科学家用语和自己使用的学生惯用语皆可的则很少。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。