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We retrospectively analyzed clinical and radiographic parameters to predict the final kyphotic angle in spinal tuberculosis and to identify patients at risk of unfavorable outcomes at an early stage of the disease when surgery may be indicated.

回顾性的分析了临床和X线方面的指标来预测脊柱结核最终的后凸角,以此来预测那些在疾病的早期阶段、有手术指征的患者所面临的进行性恶化的情况。

A multinational team coordinated by Tom Misteli at the National Cancer Institute of the National Institutes of Health in Bethesda, Md., has found that, in mice with a disease resembling Emery-Dreifuss muscular dystrophy, lamin A or C protein defects interfere with the way cell nuclei normally localize in skeletal-muscle fibers at the point where each fiber receives signals from a nerve cell.

由美国国立卫生研究院所属的国家癌症研究院的研究者Tom Misteli所领导的多国合作的研究团队在对 Emery-Dreifuss muscular dystrophy Emery-Dreifuss进行性肌营养不良实验鼠的研究中,发现了这些实验鼠的不正常的lamin A 或 C 蛋白,干扰了骨骼肌细胞核在骨骼肌细胞中的正确位置,而这一位置正是肌肉细胞从神经细胞处接受刺激信号的地方。

Methods: Fifteen cases were divided according to their clinical characteristics: 7 cases of MELAS, 4 cases of pure mitochondrial myopathy, and 4 cases of CPEO.

线粒体病患者15例,根据临床表现分为3组,线粒体脑肌病伴高乳酸血症、卒中样发作组7例,单纯型线粒体肌病组4例,慢性进行性眼外肌麻痹组4例。

Parkinson's disease is one of aging diseases, of which progressive degeneration of the mesencephalic dopaminergic neuron is its pathologic hallmark.

帕金森氏病(Parkinson's disease,PD)是以中脑多巴胺神经元进行性退变为主要病理特征的老年性疾病。

Autosomal dominant polycystic kidney disease , one of the most common monogenetic human disorders, is characterized by the formation and progressive expansion of multiple cystic lesions, which compromise the function of normal renal parenchyma and lead to nearly 10% of cases of end-stage renal failure in adults.

中文题名角质细胞生长因子在ADPKD肾囊肿组织中的表达及对囊肿衬里上皮细胞增殖作用的研究副题名外文题名 Expression of keratinocyte growth factor in ADPKD cystic tissue and effect of proliferation on ADPKD cyst-lining epitheliar cells 论文作者刘沙勤导师梅长林朱有华教授学科专业内科学研究领域\研究方向学位级别博士学位授予单位第二军医大学学位授予日期2002 论文页码总数104页关键词角质细胞生长因子肾病囊肿衬里上皮细胞株肾囊肿馆藏号BSLW /2003 /R692 /1 ADPKD是人类为之付出昂贵代价的一种全身性遗传性疾病,是引起慢性肾功能衰竭的第四位病因,在临床上以肾脏满布大小不一并不断增大的囊性液泡、最终引起肾功能进行性损害为特征性的改变。

Myoblastic cells from patients with PM had a weaker ability of developing into the myotubules, thus they were unable to perform effective regeneration, which resulted in a progressive necrosis. The exogenous bFGF could promote the division and proliferation of the muscle cells in vitro . These results shield a light on bFGF's potential role in preventing and treating PM.

PM患者受损腓肠肌在体外有再生能力,但融合成肌管能力极弱,存在再生障碍,不能对变性、坏死的肌纤维形成有效再生,故呈进行性肌纤维耗竭;外源性bFGF可促进PM患者体外培养骨骼肌细胞增殖分裂,并可促进肌管成熟,对进展性肌病应具有防治作用。

Affected individuals may present with sleep disturbances, personality changes, ATAXIA; APHASIA, visual loss, weakness, muscle atrophy, MYOCLONUS, progressive dementia, and death within one year of disease onset.

受感染的人可以有睡眠紊乱,个性改变,共济失调,失语症,视觉丧失,物理,肌肉萎缩,肌阵挛,进行性痴呆等症状,并且会在发病的一年内死亡。

Results The initial and prominent symptoms include depression, insomnia, headache, dizziness, memory impairment and gait ataxia. The most common symptoms include progressive dementia and myoclonus.

结果 CJD患者以进行性痴呆和肌阵挛最常见,首发症状多为抑郁、失眠、头痛、头晕、记忆力减退及行走不稳。

To discuss the clinical features and diagnosis of Myositis Ossificans Progressiva.

目的 探讨进行性骨化性肌炎的临床特征和诊断要点。

Methods Report a case of Myositis Ossificans Progressiva, analyze the clinical features, diagnosis, differential diagnosis with a review of literature.

报告1例进行性骨化性肌炎病例,结合文献,分析该疾病的临床特征,总结诊断要点和鉴别诊断。

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