还原酶

Antifolate Alimta derived from pyrrolo[2,3-d]pyrimidine is a multitargeted antitumor agent, it can inhibit at least five major folate-dependent enzymes: thymidylate synthase, dihydrofolate reductase, glycinamide ribonucleo -tide formyltransferase, aminoimidazole ribonucleotide formyl transferase and C-1 tetrahydrofolate synthetase(C1-S).

吡咯并[2，3-d]嘧啶类叶酸拮抗剂Alimta是一种多靶向的抗癌药物，它能抑制至少五种叶酸依赖性酶：胸苷合成酶、二氢叶酸还原酶、叶酰多聚谷氨酸合成酶、甘氨酰胺核糖核苷酸转甲酰酶及C1-四氢叶酸合成酶(C1-S)。。

In nature, some green algae can produce hydrogen after incubation under anaerobic conditions, during which hydrogenase is synthesized and activated.

自然界中存在于藻类和细菌中的氢酶是高效的催化氢气氧化和质子还原的氧化还原酶，在生物产氢和能量转换过程中发挥着重要的作用。

From the femur bone density analysis of protein expression, we can see that light chain lactoferrin, annexin decreased and the expression of enolase, ATP synthase, acetyl-coenzyme A reductase, the expression of troponin, may be related to ovariectomized femoral bone density in osteoporosis-related happened; strong bone of the femoral osteoporosis Po intervention effect may be related to reduced enolase, ATP synthase, troponin, CK-MB, acetyl phosphoglycerate enzyme, the expression of myosin, and the increase in lactoferrin light chain, pyruvate kinase isoenzyme, protein expression crown.

从股骨密质骨蛋白质组表达分析可知，乳铁蛋白轻链、膜联蛋白A3的表达下降及烯醇化酶、ATP合酶、乙酰辅酶A还原酶、肌钙蛋白的表达增强，可能与去卵巢后股骨密质骨骨质疏松的发生相关；强骨宝对股骨骨质疏松的干预效应可能与下调烯醇化酶、ATP合酶、肌钙蛋白、肌酸激酶同工酶、磷酸甘油酸变味酶、肌球蛋白的表达，和上调乳铁蛋白轻链、丙酮酸激酶同工酶、冠蛋白的表达有关。

In addition, SW480 and HCT116 cells were treated with deoxycholic acid for 15, 30, 45, 60, 90 and 120 minutes. It was found that the deoxycholic acid treated cells showed an elevation of ATP activity by 12.35 %, 20.08 %, 29.69 %, 33.56 %, 45.85 %, 54.32 %, respectively. While the HCT116 treated cells, showed an elevation of ATP activity by 3.69 %, 5.59 %, 8.52 %, 12.26 %, 16.52 %, 19.71%, respectively.From the experiments conducted using the cell lines described above, it was further confirmed that genes CYP7A1 (cytochrome P450, family 7, subfamily A, polypeptide 1), AKR1D1 (aldo-keto reductase family 1, member D1), ALDH1A1 (aldehyde dehydrogenase 1 family, member A1), BAAT (bile acid Coenzyme A: amino acid N-acyltransferase), ABCA1 (ATP-binding cassette, sub-family A, member 1), APOC3 (apolipoprotein C-III), LIPA, LIPE (lipase, hormone-sensitive), PTGER2 (prostaglandin E receptor 2) and PTGS2 (prostaglandin-endoperoxide synthase 2) were up-regulated.

此外，为了证实其脂肪代谢产物胆酸对细胞癌化的影响，亦使用SW480和HCT116细胞株，经由脱氧胆酸在15分钟、30分钟、45分钟、60分钟、90分钟和120分钟处理后，其细胞增生比率分别有12.35%，20.08%，29.69%，33.56%，45.85%和54.32%(p.05)以及3.69%，5.59%，8.52%，12.26%，16.52%和19.71%(p.05)上升情形，并从这些细胞株进一步证实CYP7A1(细胞色素P450-7A1)、AKR1D1(醇醛酮还原酶-1-D1)、ALDH1A1(醛脱氢酶-1-A1)、BAAT(胆酸辅酶A：氨基酸N-醯基转移酶)、ABCA1(三磷酸腺苷结合盒转运体A1)、APOC3、LIPA、LIPE(脂肪酶/激素敏感脂肪酶)、PTGER2(前列腺素E受体2)和PTGS2(前列腺素内过氧化物合成酶2)等基因表现皆有呈现向上调控的情形。

The effects of zhixiaotongmaining granules and sorbinil (a typica l aldose reductase inhibitor) on the activity of renal aldose reductase and sorbitol dehydrogenase, and on renal lesions were observed in sd rats wit h streptozotocin-induced diabetes.

利用链脲佐菌素糖尿病sd大鼠模型，观察了中药复方止消通脉宁及典型的醛糖还原酶抑制剂对大鼠肾组织醛糖还原酶和山梨醇脱氢酶活性及肾脏病变的影响。

Part one (chapter 1~4) is about the coppermediated biomimetic oxidation of naphthols and 2-naphthylamine.

中文题名氧化还原酶模型及在仿生有机合成中的应用副题名外文题名 The model of oxidoreductases and its application in biomimetic organic synthesis 论文作者谭端明导师许遵乐教授学科专业有机化学研究领域\研究方向学位级别博士学位授予单位中山大学学位授予日期2002 论文页码总数172页关键词模拟酶氧化还原酶仿生氧化铜胺络合物抗肿瘤药物馆藏号BSLW /2003 /O629 /5 本文包括两部分内容：第一部分（1~4章）为萘酚类和2-萘胺化合物在含铜化合物作用下的仿生氧化偶合反应研究。

Drugs of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors family are usually used as a very effective lipid-lowering preparations but they simultaneously block biosynthesis of both cholesterol and ubiquinone Q10, which is an intermediate electron carrier in the mitochondrial respiratory chain. It is known that reduced form of ubiquinone Q10 acts in the human LDL as very effective natural antioxidant.

HMG-CoA还原酶抑制剂是非常有效的降脂药物，但它同时抑制胆固醇和辅酶Q的生物合成，而其中辅酶Q是线粒体呼吸链中的中间电子载体，其还原形式在人LDL中是有效的天然抗氧化剂。

The results showed that the activities of urease, nitrate reductase, nitrite reductases and the yield of above ground plants were the highest with the fertilization pattern of taking 50 percent nitrogen from organic fertilizer and the other 50 percent nitrogen from urea.

结果表明：采用50%的N由有机肥提供，50%的N由尿素提供的施肥模式时，黑麦草根际土壤脲酶、硝酸还原酶、亚硝酸还原酶活性最强，黑麦草地上部产量最高。

BST16 was also proved to encode gene of PSII lOkD protein by protein prosite and conserve domain analysis. The protein encoded by BST16 contained a conserve domain PsbR of PSII lOkD protein from 48 to 140 and its carboxy terminal had an ADH_SHORT prosite of Short-chain dehydrogenases/reductases family signature from 94 to 122, which showed the protein encoded by BST16 would be a reductases.

对该基因可读框架编码的蛋白进行功能位点和结构功能域的分析，同样证明了该基因为PSⅡ 10kD蛋白编码基因，其氨基酸摘要序列 48刁位含有一个保守的光合系统＊ 10kD蛋白结构域 PSbR，在蛋白的猿基端有一个保守的短链脱氢酶／还原酶家族特征序列ADHSHORT（Short－chain dehydrogenases／reductases family signature），位于94－122位，说明了该蛋白可能具有还原酶活性。

This article made a systematic and deep research on the property of soybean polyphenol oxidase and soybean peroxidase,including the function of the activity of polyphenol oxidase,heat stability,pH value as well as the inhibiting effect of soybean lecithin and dimercaprol.

对大豆氧化还原酶系中的多酚氧化酶和过氧化物酶的酶学特性进行了较深入系统地研究，其中包括酶活力、酶热稳定性、pH值的影响，以及大豆卵磷脂、二巯基丙醇对酶活力的抑制作用。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新