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Objective: To explore the characteristics of the synaptic transmission from contralateral ventrolateral funiculus to motoneurons in neonatal rat spinal cord slices.

目的:了解对侧腹外侧索至离体脊髓运动神经元突触传递的细胞电生理特性和介导递质。

Long-term potentiation of synaptic transmission in motoneurons induced by tetanic stimulation of ventrolateral funiculus of neonatal rat spinal cord in vitro

应用新生大鼠脊髓薄片运动神经元细胞内记录技术,对电刺激腹外侧索诱发的突触反应进行了电生理特征分析。

In more than 80% MNs, depolarization potentials with latency of 1.2±0.2 ms could be evoked by focal stimulaton of ventrolateral funiculus.

大鼠腹外侧索刺激可在80%的运动神经元诱发去极化反应。

Expression of islet-1 in spinal cord of adult rat.In grey of the spinal cord of adult rat, the results of both of ISL1 immunohistochemistry and islet-1 mRNA in situ hybridi-zation showed that islet-1 gene expressed predominantly in the nuclei of motoneurons in ventral region and some cell around central canal and dorsal region. In white of spinal cord, the expression of islet-1 located in astroglia in anterior and dorsal funiculus.

在正常成年大鼠脊髓灰质中,ISL-l免疫组化和islet-lmRNA原位分子杂交结果都显示islet-1在腹侧角运动神经元中有相当强度的表达;在中央管周围和背侧角胶状质也有islet-1阳性表达细胞存在;在脊髓白质中,islet-l在腹侧索和背侧索中的星形胶质细胞有表达,外侧索相对较少。

Results: On day 12~ 18, rats were paralyzed on its 2 hind limbs, the coronal sections of lumbosacral enlargement of spinal cord with HE stainning showed that there were dilated capillaries, perivascular oversleeve-like inflammatory infilltration and anterior-horn motor-neuron hydropic degeneration.

结果:在接种后12~18天,大鼠出现双后肢瘫,脊髓横切片HE染色可见血管周围袖套样炎性细胞浸润和前角运动神经元肿胀变性。

We have used our anti-MNTF monoclonal antibody and MNTF-anti- idiotypic monoclonal antibody (MNTF-Id-McAb) to study the changes in localization and quantities of MNTF and its receptor in tongue muscles of 30 adult rats after 4 days, 2, 3 and 5 weeks, and 2 and 5 months of post-denervation of the hypoglossal nerve.

用本实验室制备的运动神经元诱向因子单克隆抗体和与其受体能特异结合的MNTF抗独特型单抗(MNTF-Id-McAb),对切断一侧舌下神经的30只大鼠舌内肌,分别在手术后4d,2周、3周和5周以及2个月和5个月,检测其MNTF和MNTF受体定位和含量的变化。

Lamina Ⅸ is composed of nuclei containing larger motor cells.

层主要由含大型运动神经元的核团组成。

The main purpose of this study is to develop a BCI system for patients with lower motoneuron diseases to control external effectors.

本研究的主要的目的是发展一具由人脑电脑介面所控制的机械手臂来辅助患有下运动神经元疾病患者控制周遭环境。

GDNF has a potential clinical value and inestimable future in the treatment of motoneuron diseases.

运动神经元疾病的治疗上,具有潜在的临床价值和不可估量的前途。1GDNF的分子结构人GDNF基因位于5号染色体(5p12-13.1)处

Overall, these findings have challenged the diagnostic classification system set by clinical judgement and triggered the notion of heterogeneity in motoneuron disease.

这些发现已经挑战了以临床判断为基础的诊断分类系统,触发了运动神经元疾病多相性的观念。

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