过氧

Aegle marmelos ; Anti-lipid peroxidation ; 4-Methoxy-1-methyl-2-quinolone; Superoxide dismutase; Catalase ; GSH-peroxi

木桔；抗脂质过氧化作用； 4－甲氧基－1－甲基－2－喹诺酮；超氧化物岐化酶；过氧化氢酶；谷胱甘肽过氧化物酶

In this thesis,the AM1,MNDO,MINDO/3(mainly AM1)and INDO/S-CI semiempirical MO methods were used toinvestigate the excited-state intramolecular protontransfer reactions of salicylic acid derivatives—salicylic acid,methyl salicylate,salicylaldehyde,o-hydroxyaceto-phenone,salicylamide and 3-hydroxy-picolinamide (6 conformers and 2-3 anion species);2-(2'-hydroxy-5' methylphenyl) benzotriazole(4 conformers),2-(2' hydroxyphenyl) benzimidazole (3 conformers and 3anion species),Bis-2,5-(2-benzoxazolyl)hydroquinone(3 conformers),2-(2'-hydroxyphenyl)benzothiazole(2conformers) and 7-azaindole dimer (2 conformers).Theinvestigations were described as follows.Geometry optimization,relative stability andhydrogen bonding energy First,for sylicylic acid derivative molecules,the AM1,MNDO and MINDO/3 methods were used toinvestigate ground-state geometry optimization,energies,relative stabilities and hydrogen-bondingenergies on the five kinds of the molecules(designing 6 conformers and 2-3 anion species).Comparing with experimental data,the optimizedgeometry,the order of stability,the hydrogen-bonding energies and the distances between O-O in O-H..O hydrogen bonds by AM1 method were in agreementwith the experimental data,however,the C-C bondlengths optimized by MNDO and MINDO/3 were longer,C-O and O-H bond lengths were shorter;for C-N bondlengths,the results opitimized by MNDO method werethe same as those by AM1 method,nevertheless the C-Nbond lengths given by MINDO/3 method were muchshorter.For some sylicylic acid derivatives(e.g.methyl salicylate,salicylamide),the order ofstabilities on the conformers given by MNDO andMINDO/3 methods were not in agreement with theexisting conformers deduced by experimental methods,and the hydrogen bonding energies calculated by MNDO.and MINDO/3 methods were smaller.Second,the studyon the other systems found that the optimizedgeometry of the proton-transfered product with INDOmethod could not be obtained,only could theoptimized geometry of reactant be obtained,and thecalculated hydrogen bonding energies were greater.Many results of calculation indicated that the studyon the excited-state intramolecular proton transferreaction system using AM1 method was suitable andreliable.

本论文用AM1、MNDO、MINDO/3（主要是AM1）和INDO/S-CI半经验分子轨道方法对水杨酸衍生物系列——水杨酸、水杨酸甲酯、水杨醛、O-羟基乙酰苯酮、水杨酰胺和3-羟基吡啶酰胺（6种异构体和2-3种阴离子）；2-（2'-羟基-5'-甲基苯基）苯并三〓唑（4种异构体）；2-（2'-羟基苯基）苯并咪唑（3种异构体和3种阴离子）；2，5-二间氮杂氧茚氢醌（3种异构体）；2-（2'-羟基苯基）间〓杂硫茚（2种异构体）和7-〓吲哚二体（2种异构体）的激发态分子内质子转移反应在以下几个方面进行了较系统的理论研究：几何构型优化和相对稳定性及氢键能首先以水杨酸衍生物系列分子为例，用AM1、MNDO和MINDO/3方法考察了5种分子（每种分子设计6种异构体和2-3种阴离子）的基态几何构型优化，能量、相对稳定性和氢键能计算，通过和实验数据进行比较，AM1方法给出的优化几何构型、稳定性次序、氢键能和O—H。。。O氢键的0—0距离与实验数据吻合最好，MNDO和MINDO/3方法优化的C-C键长偏长，C-O键和O-H键长偏短；对于C-N键长，MNDO和AM1优化结果差别不大，而MINDO/3给出了过短的C-N键长，MNDO和MINDO/3方法给出的有些水杨酸衍生物分子（如水杨酸甲酯和水杨酰胺）异构体的稳定性次序和实验上推测的可存在异构体结果不一致，MNDO和MINDO/3方法给出的氢键能偏低，对其他体系的研究发现INDO方法常常不能得到质子转移产物的优化几何构型，只能得到反应物的优化构型，并且估算的氢键能偏高，大量的计算结果表明AM1方法对本论文研究的激发态分子内质子转移反应体系是适宜和可靠的。

The staining of F-actin in the ischemia reperfusion group was decreased significantly （P.05） compared with the normal control group. There was a marked loss of canalicular microvilli and distension of canalicular lumen in the ischemia reperfusion group. The staining of F-actin in the LA group was significantly increased than those in the I/R group （P.05）. Conclusions: Ischemia reperfusion induces an disruption of bile canalicular F-actin microfilaments and a loss of microvilli. Alpha-lipoic acid can protect bile canalicular F-actin microfilaments against IRI.

肝脏I/R可造成胆小管F-actin微丝破坏、微绒毛丧失，导致胆小管收缩减弱，胆汁排泄功能受损，这可能是大鼠肝脏I/ R后缺血型胆道病变发生的主要机制；α-硫辛酸通过清除氧自由基，降低脂质过氧化反应，调节细胞内氧化剂-抗氧化剂的含量，保护胆小管F-actin微丝结构免遭缺血再灌注损伤破坏，进而预防和治疗缺血型胆道病变。

The effect of various preservative flukd with or without antagonists at 15℃ and 4℃ on the ultrastructure of fetal rat brain tissue in vitro hak been observed. The levels of oxygen free radical and liperoxide were also analysed by measuring SOD and MDA.

观察了室温与4℃条件下，含钙拮抗剂和不含钙拮抗剂的不同保存液对胎鼠脑组织超微结构的影响；并利用超氧物岐化酶和丙二醛为指标，观察了不同保存液保存的离体胎鼠脑组织中自由基和脂质过氧化水平的变化。

tonifing qi and nourishing yin and promoting blood to restore luo theropy can improve the endothelial function, relief coronary spasm, get rid of OFR and inhibit hyperoxidation of lipid, reduce blood thickness and platelet activity, so reliefathrosclerosis and prevent the formation of throbosis. So unstable angina is treated.

益气养阴活血通络法能缓解冠脉痉挛，改善血管内皮功能，清除氧自由基，抑制脂质过氧化，降低血液粘度和血小板活化，从而起到延缓动脉粥样硬化，防止血栓形成的作用。

Objective: To observe oxygen-free-radical clearing ac tivity and anti-l ipid peroxidation of Shengyaling injection in vitro.

目的：观察升压灵注射液清除氧自由基能力和抗脂质过氧化作用。

BMG alloys were annealed isothermally at different temperatures and the precipitation phases were investigated.

全面系统地研究了母合金氧含量、熔体过热水平和冷却速率对合金的玻璃形成能力的影响。

The total flavone in antioxidant substance extracted from leaves of tartary buckwheat and its scaveninging function to OH and O(superscript - subscript 2) were determined by photometry and the inhibitory action to Lipin peroxidation and its synergy with other substances were studied by iodimetry in the experiment.

从苦荞叶中提取抗氧化性物质，用光度法测定提取物中总黄酮的含量及对羟自由基和超氧阴离子O(上标-下标 2的清除作用，并采用碘量法研究了苦荞叶提取物对脂质过氧化的抑制作用及与其他物质的协同作用。

These findings suggested that protection of VEC and inhibition of platelet activation as well as ET releasing, and strengthening intracellular antioxidant defense system might be one of the potential machinism of the beneifitial effects of YXT capsule in treating UA.

提示愈心痛胶囊的疗效可能是通过保护VEC免受损伤，对抗ET，抑制血小板活化，清除体内氧自由基和减轻脂质过氧化损伤等机制来实现的。

Objective: To study the effects of Melastoma dodecandrum flavonoids on scavenging oxygen free radicals and inhibiting lipid-peroxidation of mice liver mitochondria in vitro.

目的：研究地菍总黄酮(Melastoma dodecandrum flavonoids，MDF)清除氧自由基与抗脂质过氧化作用。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。