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The results showed that HGF not influenced the proliferation and osteogenic differentiation of bone marrow-derived mesenchymal stem cells.

结果表明,重组人HGF不影响骨髓间充质干细胞的增殖和向成骨细胞的分化,但可明显促进骨髓间充质干细胞的迁移并抑制anoikis诱导的细胞凋亡;PI-3K和MAPK途径参与了HGF促进细胞迁移的作用。

In this part, the densities of sodium benzoate, sodium nitrobenzoate, sodium chlorobenzoate and sodium methylbenzoate in DMFwater mixed solvents have been measured at 298.15K with an Anton Paar Model 55 densimeter. From these densities, apparent molar volumes and partial molar volumes have been calculated, transfer volumes from water to DMF-water mixtures and substituent contributions to the transfer volumes have also been obtained. Solvent and substituent effects are discussed in detail. The Scaled Partical Theory has been applied to the ternary solutions to evaluate the partial molar volumes of cavity formation and the volumes change associated with solute-solvent interaction.

选择了含有取代基团的芳香类有机电解质,主要是苯甲酸钠、硝基苯甲酸钠、氯苯甲酸钠和甲基苯甲酸钠的邻、间、对同分异构体作为研究对象,用DMA 55型振荡管密度计测定了它们在不同质量百分数组成的DMF-水混合溶剂中的密度,利用这些密度数据,计算了表观摩尔体积和偏摩尔体积,得到了这些单取代苯甲酸钠从水到DMF-水混合溶剂中的迁移偏摩尔体积及苯环上不同位置的取代基对迁移偏摩尔体积的贡献值,讨论了溶剂效应和取代基效应,并将定标粒子理论应用于此三元电解质溶液中。

It stably subsided after its formation. During Palaeogene ang Neogene salt-forming, Kuqa basin experienced strong-weak-strong tectonic stages, and its center of subsidence moved gradually from north to south and depocenter from northwest to east and southeast. Because of tectonic differentiation, series of second depression formed in Kuqa basin.

盆地自形成以来一直处于稳定的沉降状态,在古近纪和新近纪成盐期,盆地经历了强-弱-强3个构造演化阶段,其沉降中心由北而南逐渐迁移,沉积中心由北西逐渐向东、南东方向迁移,盆地内的构造分异渐趋明显,形成了一系列次级凹陷。

The vein grafts with perivenous support by fibrin glue demonstrated a statistically decrease in neointimal and medial hyperplasia compared with non-supported vein grafts(p.01). immunohistochemical analysis showed that the expression of proliferating cell nuclear antigen was inhibited significantly in fs group compared with ns group. almost intact endothelium was showed in fs grafts(p.01). but in ns grafts there were severe endothelium damages where lymphocytes infiltrated. in ns grafts, the smooth muscle cells were hyperplasia and migrated to intimal, whereas in fs group, the hyperplasia of smooth muscle cells were inhibited and migrated to adventitia.

免疫组化结果显示与ns组相比,fs组移植静脉细胞增殖核抗原表达明显受到抑制;ns组内皮层损伤严重,有淋巴细胞侵润,而fs组内皮层则几乎完好无损(p.01);在ns组平滑肌细胞增殖活跃且向内膜迁移,fs组平滑肌细胞增殖受到抑制,且向外膜迁移;在fs组移植静脉外膜有丰富的成熟微小血管网形成,但是在ns组,微小血管数量则非常少。

The obtained potential energy curves disclosed that a four-state cycle existed in the ground and excited states. It was also found that the activation energy for the methyl transfer was higher compared to the phenyl transfer, which was consistent to the experimental results that the photoisomerization of the phenyl substituted derivative was more rapid than the methyl substituted derivatives.

对反应势能面的研究发现,在光异构化反应中化合物M21和M21、M31的基态和激发态虽然都可以构成四能级反应过程,但由于M21异构化过程的活化能较高,使其所构成的四能级反应难以进行,这就从理论上解释了迁移基团为甲基的M21变色性能低于迁移基团为苯基的M31的实验结果。

The human cartilages are composed of chondrocyte and extracellular matrix,the form of chondrocytes are hypertrophy and the quantity are less;the ECM of cartilage are compised of type II collagen and proteoglycan. Articular cartilages are all hyaline with little fibers. Trauma and arthritis are the main cause of cartilage injury,the ommilayer injury ofcartilage can be recovered by marrow,but because of without stimulation mechanism,the new tissues are merely fibrocartilages,they can not be coincide with hyaline cartilage in menchanics;the purely damage of articular cartilage can not stimulate chondrocyte to regenerate because of without blood circulation,thus,the plerosis of articular catilage can not depend on the proliferation of local chondrocyte.Ever since,people tried their best to find a way to reconstruct articular cartilage.

造成人体关节软骨损伤的原因主要为创伤和关节炎,关节软骨全层损伤可由于骨髓中间充质干细胞的高速增殖修复,但这种修复由于缺乏相应的刺激机制,只能形成纤维软骨,而不能形成符合关节生理、力学要求的透明软骨;单纯软骨部分损伤软骨组织内无血管,软骨细胞迁移迟缓,无法使损伤区域软骨细胞再生,因此,关节炎及关节创伤后的软骨修复不能依赖于软骨细胞的增殖和迁移

The human cartilages are composed of chondrocyte and extracellular matrix , the form of chondrocytes are hypertrophy and the quantity are less; the ECM of cartilage are compised of type Ⅱ collagen and proteoglycan. Articular cartilages are all hyaline with little fibers. Trauma and arthritis are the main cause of cartilage injury, the ommilayer injury ofcartilage can be recovered by marrow, but because of without stimulation mechanism, the new tissues are merely fibrocartilages, they can not be coincide with hyaline cartilage in menchanics; the purely damage of articular cartilage can not stimulate chondrocyte to regenerate because of without blood circulation, thus, the plerosis of articular catilage can not depend on the proliferation of local chondrocyte.

造成人体关节软骨损伤的原因主要为创伤和关节炎,关节软骨全层损伤可由于骨髓中间充质干细胞的高速增殖修复,但这种修复由于缺乏相应的刺激机制,只能形成纤维软骨,而不能形成符合关节生理、力学要求的透明软骨;单纯软骨部分损伤软骨组织内无血管,软骨细胞迁移迟缓,无法使损伤区域软骨细胞再生,因此,关节炎及关节创伤后的软骨修复不能依赖于软骨细胞的增殖和迁移

The human cartilages are composed of chondrocyte and extracellular matrix , the form of chondrocytes are hypertrophy and the quantity are less; the ECM of cartilage are compised of type Ⅱ collagen and proteoglycan. Articular cartilages are all hyaline with little fibers. Trauma and arthritis are the main cause of cartilage injury, the ommilayer injury ofcartilage can be recovered by marrow, but because of without stimulation mechanism, the new tissues are merely fibrocartilages, they can not be coincide with hyaline cartilage in menchanics; the purely damage of articular cartilage can not stimulate chondrocyte to regenerate because of without blood circulation, thus, the plerosis of articular catilage can not depend on the proliferation of local chondrocyte. Ever since, people tried their best to find a way to reconstruct articular cartilage.

中文题名人骨髓基质干细胞成软骨诱导及多孔复合材料作为细胞载体的体外实验研究副题名外文题名 Cartilage induction of human mesenchymal stem cells and experiment on compound porous materials as cells' scaffold in vitro 论文作者刘晓岚导师周江南学科专业外科学研究领域\研究方向学位级别博士学位授予单位中南大学学位授予日期2003 论文页码总数68页关键词骨组织工程软骨细胞骨髓基质干细胞壳聚糖高分子外消旋聚乳酸馆藏号BSLW /2003 /R68 /10 造成人体关节软骨损伤的原因主要为创伤和关节炎,关节软骨全层损伤可由于骨髓中间充质干细胞的高速增殖修复,但这种修复由于缺乏相应的刺激机制,只能形成纤维软骨,而不能形成符合关节生理、力学要求的透明软骨;单纯软骨部分损伤软骨组织内无血管,软骨细胞迁移迟缓,无法使损伤区域软骨细胞再生,因此,关节炎及关节创伤后的软骨修复不能依赖于软骨细胞的增殖和迁移

He results showed that prestimulation of BCMEC with TNF(100 kU·L 1 ) enhanced monocytes adhesion to and migration...

NF(100kU·L-1)可促进单核细胞与BCMEC的粘附及迁移,其促粘附与迁移作用具明显的时效关系。

The basic procedures of the experiments were:(1)rule training:thisis pretraining in order to make subjects attend gradually to the numberdimension of stimuli,and master the rule of number matching.(2)formaltraining:a variety of cards loading number"3"or"5"served as samplesand comparisons.(3)transfer test,test trials were interposed among usualtraining trials of each session,the number is from 1 to 9,and three typestransfer test were proceeded.

两个实验的基本程序为:(1)规则训练阶段:用几个步骤使被试逐渐注意刺激的数维度,并掌握数目匹配原则;(2)正式训练阶段:数目3、5的多种变式作为样本和比较刺激,通过被试在各种样本和比较刺激对上的反应分析它们所利用的线索;(3)迁移测试阶段:将迁移测验随机插入每天的正式训练中,数目扩展为1至9,以验证被试数能力的抽象程度。

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