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Methods Seventy-eight adult female PVGrats were divided into experimental group (n=60) and control group (n=18), intraneural injection technique was used to supply three kinds of NO donors with different half-life(DETA NONOate, DPTANONOate and Spermine NONOate) or saline into the rat sciatic nerve subperineurally under light microscope. At the 1th,2th,3th,7th,and 14th day of duration after sciatic nerve injection, a segment of injected sciatic nerve was taken out and embedded it in TAAB resin after tissue processing. Then it was cut into thin layers (1μm) and the histological changes were observed under high power microscope, meantime the number of degenerated axons were counted.

选择78只雌性PVG大鼠,分为实验组和对照组,以在体神经内微注射实验方法,将三种半衰期不同的NO供体(DETA NONOate,DPTA NONOate和Spermine NONOate)及生理盐水分别注入大鼠左侧坐骨神经的神经束膜下,于注射后的不同时间(1天、2天、3天、7天和14天)取出注射部位的坐骨神经,经组织学处理后做成树脂包埋块,以超薄切片机切片,然后在高倍显微镜下观察并计数神经横断面的变性轴突数目。

RESULTS The degenerative changes of nerve ending in Meissner's corpuscles were observed after 1 month of denervation, and the basic structure of the corpuscles had no obvious changes. After 3 months, the axons of corpuscles were disappeared, and the volume of corpuscles was shrunk. The basic structure of nerves was disappeared, and the lemmocyte and neurolemma plate were changed after 5 months.

结果 失神经1个月时触觉小体内的神经末梢已有溃变,触觉小体的基本结构无明显改变;3个月时轴突消失,触觉小体的体积开始萎缩;5个月时神经结构消失,膜细胞及其膜板亦开始改变;8个月时触觉小体内胶原纤维含量逐渐增多;12个月时触觉小体内膜结构与膜间基质完全消失,被胶原纤维代替。

Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo.

鱿鱼神经轴突的钠离子与钾离子电流〉,《生理科学期刊》, 116期(1952), 449-472页, Hodgkin,与 Huxley。

Immunofluorescence histochemistry combined with retrograde tracing technique was employed to observe the effects of masseteric nerve transection on the expression of Trk ( tropomyosin-related kinase) receptor proteins, namely TrkA, TrkB and TrkC in the trigeminal mesencephalic nucleus (Me5) of the rat.

本研究应用免疫荧光结合逆行束路追踪技术观察了轴突切断对支配咬肌的三叉神经中脑核(Me5)神经元所含Trk受体蛋白,即TrkA、TrkB和TrkC表达的影响。

Furthermore, MSC p43 depletion in mice caused disorganization of the axonal NF network. Mechanistically, MSC p43 is required for maintaining normal phosphorylation levels of NFs.

进一步观察发现,MSC p43 蛋白参与神经元轴突发育过程中所必需的 neurofilament 蛋白磷酸化正常水平的维持。

Results: The shape of the mesenchyma stem cells change after the inducement of TPCD and a part of them even have the axon .

结果 经菟丝子总多糖诱导的骨髓间充质干细胞形态发生改变,部分细胞长出轴突

Results we found positive labeling for both anp and nos in different types of cells including the spiral modiolar artery, stria vascularis, spiral limbus, spiral ligaments, basilar membrane, organ of corti, spiral ganglion, and macula sacculi. however, no immunoactivity was found in the reissner membrane and tectorial membrane.

结果 在耳蜗各转螺旋动脉和血管纹,螺旋缘、螺旋韧带和corti器显示双阳性染色,螺旋神经节细胞及囊斑神经上皮细胞膜及轴突nos阳性染色,胞质anp阳性染色;盖膜、前庭膜阴性染色。

The stage of neuron development during which many axons become myelinated by glial cells .

神经胶质细胞造成轴突髓鞘化这段期间的神经元发展阶段。

At midgestation, cortical axonal tracts in the emerging white matter were PSA-NCAM+, but they were not yet myelinated, based on the lack of myelin basic protein immunoreaction.

妊娠中期发生的皮质轴突束是PSA-NCAM+的,但是还没有髓鞘,因为缺乏髓磷脂碱性蛋白的免疫反应。

Nerve growth factor is the fist found cellar factor that regulates cell growth, and it plays a very important role at the phrase of nerve development、neuraxon growth、 neurotransmitter synthesization and cell apoptosis and so on.

神经生长因子是最早发现的细胞生长调节因子,在神经元的发育、轴突的生长、递质的合成及细胞的凋亡等阶段起着非常重要作用。

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