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Objective To investigate the role of hypoxia inducible factor-1α(HIF-1α) and von Hippel-Lindau in murine endochondral ossification.

目的 研究低氧诱导因子1α(HIF-1a)和von Hippel-Lindau在成骨细胞水平对小鼠软骨内成骨过程的调控机制。

HXHY decoction promoting the expressions of serum BGP, CollagenⅠ, TGF-β1 of callus of fracture sides as to accelerate endochondral ossification.

活血化瘀汤能通过促进骨折大鼠Ⅰ型胶原、骨钙素、TGF-β1 mRNA及蛋白的表达,促进软骨内成骨。

AIM To study the effects of total velvet antler polypeptides, native VAP and synthetic VAP on proliferation of epidermic cells and fibroblasts.

方法分离乳鼠表皮细胞和家兔肋软骨细胞,体外加入TVAP ,nVAP和sVAP ,观察其对 [3H]TdR参入细胞DNA合成的影响。

Objective to study on the effects of radiofrequency energy and treatments time on chondrocytes and matrix of fibrillated articular cartilage.

目的:探讨射频消融能量大小及处理时间与关节软骨细胞及基质损伤效应之间的关系。

Experimental study on age-related changes in expression of tissue inhibitor of metalloproteinases-3 (TIMP-3) associated with transition from notochordal nucleus pulposus to fibrocartilaginous NP in rabbit intervertebral disc.

研究设计:兔子椎间盘脊索髓核向纤维软骨NP转变过程中金属蛋白酶3(TIMP-3)组织抑制因子年龄相关改变的实验性研究。

Experimental study on age-related changes in expression of tissue inhibitor of metalloproteinases-3 (TIMP-3) associated with transition from notochordal nucleus pulposus to fibrocartilaginous NP in rabbit interertebral disc.

研究设计:兔子椎间盘脊索髓核向纤维软骨NP转变过程中金属蛋白酶3(TIMP-3)组织抑制因子年龄相关改变的实验性研究。

Results: The degenerative changes were demonstrated in the knee joints injected with papain and L-cysteine, such as the lower activity scope of knee joint, thinner and worse articular cartilage, fissuration, fibrous degeneration, fibrillation and destroyed cartilage matrix.

结果:实验侧关节注射木瓜蛋白酶后,活动范围明显低于对照侧,关节软骨变薄且有裂隙形成、纤维变性、基质分解破坏等退行性改变,并随观察时间的延长而进一步发展。

Methods A novel injectable thermosetting gel was made of chitosan and glycerophosphate mixture.

方法以体外培养扩增的兔关节软骨细胞为种子细胞,以自制温固化可注射C/GP凝胶为支架,按5 10^7/ml细胞浓度复合体外培养。

Results Intramuscularly injected with hydrochloric dexamethasone for6weeks,the rabbits in osteoporosis model group showed obvious signs of osseous destruction such as destruction in the facies articularis of femur head,rar-efaction and fragmentation of trabecula,disappearance of myeloid cells,while those in control groop showed few sign of osseous destruction.

结果 对实验兔予以肌肉注射DX6周后,正常对照组基本无骨质破坏的征象,而骨质疏松模型组则表现为股骨头关节表面软骨破坏,骨小梁稀疏、断裂,骨母细胞消失等明显骨破坏现象。

The expression of heterogenetic hGDF5 gene can induce BMSCs differentiation to chondrogenic cells.

高表达的hGDF5可以促进BMSCs向软骨表型分化,但对细胞增殖和碱性磷酸酶活性无明显影响。

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