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There may be no relation between the extent of arthrogenous muscle weakness and the extent of joint pathology in knee osteoarthritic patients.

结果:有明显软骨丧失和无明显软骨丧失的患肢屈伸膝肌群的等速肌力参数的下降程度无统计意义上的差别。结论:膝骨关节炎的肌肉软弱程度和关节病理程度不一定有关。

The purpose of this study was to prospectively analyze the clinical outcome and graft morphology of patients who received fresh, hypothermically stored, allograft tissue for the treatment of symptomatic chondral and osteochondral defects of the knee.

这项研究的目的就是前瞻性分析接受用新鲜低温冻存的同种异体骨组织治疗有症状的膝关节软骨和骨软骨缺损的病人的临床疗效和移植物的形态学变化。

The purpose of this study was to prospectiely analyze the clinical outcome and graft morphology of patients who receied fresh, hypothermically stored, allograft tissue for the treatment of symptomatic chondral and osteochondral defects of the knee.

这项研究的目的就是前瞻性分析接受用新鲜低温冻存的同种异体骨组织治疗有症状的膝关节软骨和骨软骨缺损的病人的临床疗效和移植物的形态学变化。

Bone marrow containing hematopoietic stem cells has already been known , theses another group stem cells exists in bone marrow named mesenchymal stem cells. MSCs retain the potentiality of differentiating into osteoblast, chondroblast, adipoblast, tendonblast, myoblast, cardiomyoblast, neuron, etc , which displays a bright prosperity of its use in tissue enigeering, wound healing , cell transplatation and gene therapy. MSCs can be obtained and expanded easily compared to ESC without any problems of morality , law and ethic , immunology.

最早在130年前,德国病理学家Cohnheim在研究创口愈合时就推测在创口愈合过程中出现的部分细胞可能来自骨髓。20世纪70年代,Friendenstein发现一小部分骨髓中贴壁最牢固的细胞经数此传代后形成独特的纺锤形外观,具有形成成骨细胞或软骨细胞的能力。80年代以来,许多研究小组进一步证实了Friendenstein分离到的这些细胞是多能的,在体外特定诱导条件下,可以分化为成骨细胞、软骨细胞、脂肪细胞、成肌细胞、神经元等,被称为骨髓间充质干细胞(Bone MarrowMesenchymal Stem Cells,MSCs)。

Image analysis system was used for semi-quantitive assay of TGF-βRⅠ and R Ⅱexpression, and microphotography was used to record the morphologic changes of culturedchondrocytes. The results are:1. TGF-〓 showed sequentially inhibitory and promotive effects on the proliferation of human articular chondrocytes of two week monolayer culture from one passage to eight passage.

本研究采用CellTiter 96〓单溶液细胞增殖分析试剂盒测定体外培养中的软骨细胞的增殖活细胞数量;免疫组化法测定软骨细胞TGF-βR Ⅰ、R Ⅱ,Ⅱ型胶原和S-100蛋白的定性表达;酶免分析法测定TGF-〓作用后的Ⅱ型胶原定量表达;通过图象分析仪,对TGF-βRⅠ、R Ⅱ的免疫组化染色结果进行半定量分析;本研究的实验结果如下:1。

AIM: To investigate the effect of enhanced green fluorescence protein gene transfection on the cell cycle distribution of primary cultured human chondrocytes in order to establish a tracking method of cultured human nasoseptal chondrocytes.

目的 :观察转染增强型绿色荧光蛋白基因后原代培养的人鼻中隔软骨细胞的细胞周期的变化,建立原代培养的人鼻中隔软骨细胞的示踪方法。

During the last few years a large amount of evidence has provided new insights into the biochemistry and molecular biology of cartilage, subchondral bone, and other articular tissues, which suggest distinct etiopathogenetic mechanisms in some forms of primary OA.

过去几年中的大量的证据,让我们在软骨,软骨下骨及其他关节组织的生物化学和分子生物学方面获得了新的认识,提示某些类型的原发性关节炎有不同的发病机制。

Dynamic enhancement on MR imaging coincided with histologic data showing the locations and concentrations of blood vessels in physes, epiphyses, metaphyses and other anatomic regions.

组织学研究所显示的生长板软骨、骨骺软骨、干骺端等不同解剖区域的血管解剖及分布特征与相应部位的增强率及强化快慢所提示的血供状态基本相吻合。

The soft-diet feeding has no significant effect on proliferation of cell in cartilage. But, it leads to increased number of apoptotic cell in cartilage. It suggests that decreased masticatory force induced by soft-diet feeding promote the maturation and apoptosis of cell in cartilage.

软食喂养对这一时期大鼠髁突软骨中的细胞增殖活性影响不大,但却使细胞凋亡的数量增加,提示软食喂养可能加速了髁突软骨中细胞的分化、成熟、凋亡,进而影响髁突的正常发育。

Objective To investigate the role of SOX-9(SRY-related high mobility group box gene 9)regulating the apoptosis in the hyaline cartilage cells of human cervical zygapophysial joints.

目的 探讨重组腺病毒介导的人SOX-9(AdSOX-9)对人的颈椎关节突关节软骨细胞凋亡细胞数目及Caspase-3基因表达的作用及相关意义,更好理解颈椎软骨退变的发生机制。

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