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软骨瘤

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That consider condyle, bone caruncle of 5 exemple, cartilage fibrosarcoma of 3 exemple, nerve fibroma of 1 exemple, nerve 1. The symptom after 27 patients operation all has different level improvement, live on average without tumour time is 33.5 months. Incontinent companion meets the patient relieve oneself of S1 of 5 operations reservation or above nerve root pubic feeling is lost, after manager cure function trains, 3 parts restore, 2 conserve without progress; bladder and rectum function obstacle all appear after the 12 patients art of root of S2 above nerve, after training via rehabilitation physiotherapy and function, 10 return to normal basically, 2 patients still are put in the obstacle of be convenient to both of different level. 10 withhold S3 or the patient of above nerve root can conserve constrictor function.

结果术后病理报告示:脊索瘤17例、骨巨细胞瘤5例、软骨肉瘤3例、神经纤维肉瘤1例、神经纤维瘤1例。27例患者手术后症状均有不同程度改善,平均无瘤生存时间为33.5月。5例手术保留S1或以上神经根的患者大小便失禁伴会阴部感觉丧失,经理疗功能练习后,3例部分恢复,2例无进展;保全S2以上神经根的12例患者术后均出现膀胱及直肠功能障碍,经康复理疗和功能练习后,10例基本恢复正常,2例患者仍存在不同程度的两便障碍。10例保留S3或以上神经根的患者能保全括约肌功能。

Pathological diagnosis as follows: Chon- droblastoma (3 cases), giant cell tumor of bone (3 eases), fibrous dysplasia (2 cases), non-ossifying fibroma (1 case), and esosinophilic granuloma of bone (1 case).

材料和方法:经手术病理和临床活检证实共10例,其中成软骨细胞瘤和骨巨细胞瘤各3例,骨纤维异常增殖症2例,非骨化性纤维瘤和嗜酸性肉芽肿各1例。

Results The CT imaging of sacral tumors which included 10 cases of metastasis,5 of chordoma,4 of giant cell tumor,3 of neurogenous tumor,3 of chondrosarcoma and 5 of other tumors had their different features.

结果 30例骶骨肿瘤包括转移瘤10例,脊索瘤5例,骨巨细胞瘤4例,神经源性肿瘤3例,软骨肉瘤3例,其它5例,其CT影像学表现各有异同。

The malignant tumors included osteogenic osteosarcoma,metastasis tumor(six patients,two with pathologic fractures),chondrosarcoma,malignant fibrous histiocytoma (three patients,one with pathologic fracture),fibrosarcoma,and solitary myeloma.all patients received limb savage procedure with custom knee prosthesis including sevnteen cases of hinge joint and twentyone cases of posterior stability joints.

回顾分析我院接受定制型人工关节置换进行保肢治疗的股骨远端肿瘤患者38 例,其中良性肿瘤9 例,分别是骨巨细胞瘤7例(复发性骨巨细胞瘤5 例,骨折2例),骨巨细胞瘤合并动脉瘤样骨囊肿1 例,骨母细胞瘤1 例;恶性肿瘤29 例,分别是成骨性骨肉瘤16 例,转移性肿瘤6例(骨折2例),软骨肉瘤2 例,恶性纤维组织细胞瘤3例(骨折1例),纤维肉瘤1 例,局灶性骨髓瘤1 例。

But a few cases, compared with benign, such as muscle blastoma, chondroblastoma and osteoblastoma.

但少数情况则为良性,如肌母细胞瘤、软骨母细胞瘤和骨母细胞瘤。

EMA staining was positive in 100% of chordoid gliomas, 94% of chordomas, 90% of chordoid meningiomas, and 25% of extraskeletal myxoid chondrosarcomas.

EMA表达于100%例脊索样胶质瘤、94%例脊索瘤、90%例脊索样脑膜瘤、25%例骨外黏液样软骨肉瘤。

Pankeratin highlighted 100% of chordoid gliomas and chordomas, 38% of extraskeletal myxoid chondrosarcomas, and 20% of chordoid meningiomas.

Pankeratin高表达于100%例脊索样胶质瘤和脊索瘤、38%例骨外黏液样软骨肉瘤、20%例脊索样脑膜瘤。

We found that 1 mutant EG4 cells showed typical characteristics of pluripotent stem cells which had no obvious difference with wild cells; 2 When induced by 10〓 M retinoic acid , mutant EG4 cells differentiated into adipocytes with high frequency compared with mutant cells, suggested that EGFR plays a role in adipocyte differentiation; 3 when injected into nude mice, mutant teratocarcinomas contained a large amount of connective tissues as well as skeletal muscle, while wild EG4 cells produced frequently cartilage, keratinocyte and neuroepithelium.

我们建立了稳定表达胞内区功能缺失的外源EGFR cDNA片段的EG4细胞,分析其生长分化特性,发现 1)突变型细胞可在未分化状态下维持长时间的增殖,表明EGFR对EG多能干细胞表型无明显影响;2)〓 M的维甲酸A(retinoid acid A,RA)诱导后,大部分对照组细胞分化为脂肪细胞,而突变型细胞分化为脂肪细胞的比例明显较少,表明EGFR在脂肪细胞的发育分化中具有一定的调节作用;3)畸胎瘤切片分析显示,突变型瘤组织分布有大量的未分化细胞和结缔组织,分化细胞以肌肉细胞为主;对照组瘤组织含丰富的角质上皮、软骨、神经管等依赖EGFR的分化组织。

PPO gene was not detected in the multiple myelome、 malignant fibrous histiocytoma 、malignant lymphoma、malignant neurosarcoma、solitary plasmacytoma of bone、primitive neuroectodermal tumors、lipoma、 osteosarcoma and sarcoenchondroma.

PPO基因在多发性骨髓瘤、恶性纤维组织细胞瘤、恶性淋巴瘤、恶性神经肉瘤、孤立性浆细胞肉瘤、原始神经外胚瘤、脂肪瘤、骨及软骨肉瘤等肿瘤中没有表达。在骨巨细胞瘤中有微弱表达。

There were 22 malignant tumors including 11 osteosarcomas, 5 chondrosarcomas, 2 malignant fibrous histocytomas, and one each of malignant osteoblastoma, alveolar sarcoma, rhabdomyosarcoma, malignant giant cell tumor of bone. 28 benign tumors included 27 giant cell tumors of bone and 1 benign fibrous histocytoma.

肿瘤类型:恶性肿瘤22例,其中骨肉瘤11例,软骨肉瘤5例,恶性纤维组织细胞瘤2例,恶性骨母细胞瘤、腺泡状肉瘤、横纹肌肉瘤、骨巨细胞肉瘤各1例;良性肿瘤28例,其中骨巨细胞瘤27例,良性纤维组织细胞瘤1例。

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