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Results: Compared test group with control group at 14th day of experiment, test group rats were osteoporotic. The lower bone density figures of test group showed that bones were osteoporotic and test group bone HE microtome section showed that bone trabecula was looser, os integumentale was thiner and chondrocyte was decreased.

结果:实验第14天,模型组与对照组相比,模型组大鼠骨质疏松模型建立成功:骨密度不同程度的降低、骨HE切片中骨小梁稀松、皮质骨变薄、软骨细胞层减少等病理变化。

Mallory trichrism staining exhibited light blue samples. Eight weeks following repair, CT showed round blunt defect edges in the coronal position, which had bony pustute connection with gel materials. Density at the defect region significantly increased. 3D reconstruction suggested that defects became small. After hematoxylin-eosin staining, abundant fibrous connective tissue appeared in defect regions, with bony tissues. Mallory trichrism staining revealed that maroon mature bone tissues were found, surrounded by light blue chondroid tissues. Twelve weeks following repair, coronal defect regions were filled with callus. 3D reconstruction showed that defects were repaired. Defect region and surrounding bony tissues had bony connection, with thick bone trabecula and mature Haversian system.

修复后8周,冠状位CT显示缺损边缘圆钝,与凝胶材料有骨性突起连接,缺损处密度增高明显,三维重建显示缺损范围较之前有所减小;标本苏木精-伊红染色后缺损部可见大量含血管成分的纤维结缔组织,有骨样组织结构形成,Mallory三色染色显示有褐红色成熟骨组织形成,其旁边有淡蓝色软骨样组织修复后12周,冠状位CT显示缺损区基本被骨痂填满,三维重建示缺损基本修复;缺损区域和周围骨组织形成骨性结合,骨小梁粗大,哈弗氏系统成熟。

DATA SYNTHESIS: Compared with the control group, VEGF can promote osteogenesis, bone formation and remodeling through the effect of VEGF on endochondral ossification and intramembranous ossification.

资料综合:与对照组相比,VEGF能通过对软骨内成骨、膜内成骨的影响促进骨的发生、形成和改建。

Both cyclin D1 and cdk4 were present in 1/ 8 (12.5%) osteochondroma of the jaws.

结果 软骨肉瘤cyclin D1和cdk4阳性表达率分别为70%(14/ 20)和65%(13/20),二者的阳性表达存在正相关(rs= 0.526, P 0.05);而它们在骨软骨瘤的阳性表达率均为12.5%(1/ 8),在软骨瘤无表达,与软骨肉瘤相比有显著性差异(P 0.05)。

Focus on research work and clinical studies in musculoskeletal oncology, especially about mechanism and biological therapy of osteosarcoma, such as proteomics studies of osteosarcoma, prospective control study of osteosarcoma, registration system of musculoskeletal oncology and genic tests about the familial inheritance osteoenchondroma, etc.

拟开展《骨肉瘤特异性相关抗原的蛋白质组学研究》、《骨肉瘤多中心前瞻性随机对照研究》、《骨与软组织肿瘤注册-会诊-随访登记系统》、《多发性骨软骨瘤家族遗传性基因的检测》等课题的相关研究工作,承担国家、省级和市级重大项目等课题的申报。

Sanders et al.13, in a study of twenty-four skeletally immature girls, found that a Risser sign of 0 and an open tricartilage acetabular cartilage correlated with peak height elocity.

Sanders在一项包括24例骨发育未成熟的女性的研究中,发现Risser指数0和开放髋臼三软骨与身高增长峰值相关。

Then 3 rabbits with 6 limbs of each group were killed in the 1st, 3, 5, 7, 10 and 13th week respectively, to compare the bone healing roentgenologically and histologically There was receptive reaction in fresh homogenous bone implant ati...

实验证明脱钙同种异体骨是一种较好的植入物。彼优于新鲜异体骨,与新鲜自体骨植入无显著差异。新骨及软骨出现在植入物中而不在邻近宿主骨处,表明新骨形成可能是骨诱导作用的结果。

RESULTS: During 10 - 12 weeks, in cuntrol group: The defect area was repaired by white and soft tissue that had no resistance to press. The repaired tissue was still lower than the surrounding articular surface with clear boundary. By histological observation, it was found that the defect was repaired by the mechanism similar to inflammatory reaction and the defect is ultimately filled by the hyperplasia of hyaline degenerative fibrous tissues. In filling group: the defect was repaired by semi-transparent, smooth, textured tissues with polish that had resistance to press as well as elasticity. The repaired tissue was almost similar to the shape of the surrounding cartilage,difficult to be distinguished. After histological observation, it was found that there was no inflammatory reaction, but active hyperplasia of inner bonetissue and cartilage tissues; a lot of osteoid tissues and trabeculation were found. Newlborn cartilage was fused with surrounding cartilage tissue and connected with surrounding tissues.

结果:10~12周,对照组:缺损区由白色、质软、按压无阻抗的组织修复,修复组织仍低于周围关节面,边界仍清晰可辨,组织学以类似炎症反应的机制修复缺损,最终以透明变性的纤维组织的增生来填补缺损部位;填充组:缺损区由半透明状、质韧光滑有光泽,按压有阻抗并有弹性的组织修复,修复组织与周围软骨外形上已基本相似,不易区分,组织学未见有炎症反应的过程,内骨组织和软骨组织增生活跃,并可见大量类骨组织和骨小梁形成,新生软骨和周围软骨组织融合,并与周围组织连接。

Methods Fifty healthy SD rats were fed for twentytwo months in order to build the model of aging rats, the histology of femoral bone, tibial bone and lumbal vertebra was used to observe, then we evaluated the indexes which reflect the degeneration of intervertebral disc including the quantity of collagen type Ⅱ,Ⅹ of intervertebral disc by the immunohistochemistry methods, the relative area of vascular bud, the thickness of calcified layer and uncalcified layer on cartilage endplate and the indexes which reflect the osteoporosis including the thickness ratio of cortical bone, the relative area of bone trabecula, the bone density, the max stress and straining of bone.

50只健康纯种SD大鼠,喂养22个月,建立老龄大鼠模型,进行股骨、胫骨、腰椎等组织学观察,并评价椎间盘退变的相关指标(椎间盘软骨Ⅱ型和Ⅹ型胶原表达、软骨终板血管芽相对面积、软骨终板钙化层/非钙化层厚度)与骨质疏松的相关指标(骨皮质厚度指数、骨小梁相对面积、骨密度、骨最大应力和应变)的相关性。

Furthermore, the connection between two sesamoids and metacarpal was a kind of soft tissue connection which seemed like fabric, it could exist mini-motion between two sesamoids and metacarpal, resulting in the increasing friction between the tendon of flexor pollicis longus muscle and sesamoids. Meantime, it could lead to metacarpophalangeal joints dislocation and injury the tendon sheath of flexor pollicis longus muscle.

而且,籽骨和掌骨之间没有骨性连接,为纤维软骨样软组织连接,导致籽骨和掌骨之间可以微动,拇指屈伸时,籽骨和掌骨间的微动导致拇长屈肌腱与籽骨摩擦进一步加大,籽骨易脱位,产生籽骨嵌顿于掌指关节,造成拇长屈肌腱狭窄性腱鞘损伤。

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