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Second, using DBU as the base for enolization of propargylic esters of unsaturated acids 18e-k, we developed a tandem Ireland-Claisen rearrangement /isomerization reactions. It has been shown that the reaction sequence affords triene molecules 42a-b and 43a-b in moderated to high yields. Interestingly, with allyl hexa-3,5-dienoates 18i-j as the substrate, the rearranged products underwent further aromatization to give uniquely substituted benzyl acids 44a-b.

其次,以含有活泼质子的烯酸炔丙酯18e-k为底物,在DBU为烯醇化碱、TMSCl为硅试剂的条件下,底物18e-h发生了Ireland-Claisen重排/异构化串联反应,得到完全共的三烯类化合物42a-b及43a-b;而以己二烯酸炔丙基酯18i-j为底物时,重排/异构化后的产物进一步发生电环化等反应最终得到芳构化产物——取代苯甲酸类化合物44a-b。

The results demonstrate that ACM-A is capable of intercalating between the base pairs of DNA double helix, the π-π electronic overlapping between π-electron of ACM-A and DNA stabilizes the ACM-DNA adduct, and through electrostatic interaction, the trisaccharide interacts with the minor groove of DNA owing to C(3') amino group.

实验结果表明,ACM-A主要以其蒽环平面嵌入DNA双螺旋碱基对之间,发生-等电子间相互共,同时药物糖基上C3'位的-N(CH3)2基团带正电荷,易与带负电荷的磷酸骨架产生静电吸引,从而发生沟槽作用,嵌入DNA的小沟区,这是二者之间的主要结合模式。并且,DNA与ACM-A药物原型的亲和力要强于还原后的药物代谢产物。

Other enhancements include trunnion mounting to eliminate side loads for prolonged seat life; tangential purge; and heavy-duty mounting yoke design.

其他优点还包括轴颈安装消除侧面负载,延长阀座使用寿命;正切清洗;和坚固耐用的安装架结构。

Because of the conjugated bonds, the tung oil is more activated than the soybean oil.

因为桐油分子中含有多个共双键,反应活性比豆油强。

Two-up:(1) Printing two copies of the same thing at one impression by using duplicate plates or a step-and-repeat machine.

这是一个振幅恒定的波,在共的象平面上也是如此。

The global convergence properties of the conjugate gradient methods for the unconstrained optimization problems are studied in this dissertation.

本文集中对求解无约束最优化问题的有效方法—共梯度法的全局收敛性进行分析。

This paper presents some new conjugate gradient methods for unconstrained optimization.

本文主要考虑求解无约束最优化问题的共梯度法。

It is good for a man to undergo the yoke when he is young.

3:27 人在幼年负、这原是好的。

An acid/base indicator is a weak organic acid or a weak organic base whose undissociated from differs in color form its conjugate base or its conjugate acid form.

酸碱指示剂一般是弱的有机酸或有机碱,其中酸式及其共碱式具有不同的颜色,当滴定至等当点时,过量的酸或碱使指示剂得到或失去质子,由碱式变为酸式,引起颜色的变化。

The ambiguity of DOA estimation due to ignorance of the function form of angular signal distribution is analyzed and the DOA estimation without ambiguity is given. 4. A method of DOA estimation of distributed sources is proposed by using the knowledge of the unimodal property of angular signal distribution and independence between different distributed sources.

利用角信号分布函数的共对称性,提出了基于噪声子空间的极小最小特征值一维搜索分布式目标DOA估计方法,和基于信号子空间的极大最大特征值一维搜索分布式目标DOA估计方法。

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She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了,但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场,你等着挨绳子吧!

Several theories about reigniting and extinguishing of the arc have been refered.

本文综合考虑了几种电弧重燃和熄灭理论。