转移酶

Part I Cbx4 promotes SUMO modification of DNA methyltransferase 3a Dnmt3a is one of de novo DNA methyltransferases in mammals, which are responsible for the generation of somatic methylation patterns during embryogenesis and gametogenesis.

第一部分：Cbx4促进DNA甲基转移酶3a的SUMO化修饰 Dnmt3a是哺乳动物中的一个起始性甲基转移酶，负责在胚胎发育和配子发生过程中创建各类细胞的甲基化谱式。

Galactosyltransferase 1 is the first cloned glycosyltransferase. It had been regarded as a house-keeping gene for a long time. In our previous investigation, it was found that GaT I was an intraction protein of SGT, and EIAF, one of the Ets family members could regulat its expression.

1，4半乳糖基转移酶是一个最早克隆的糖基转移酶，长期以来被认为是一个管家基因，本实验室以前的工作表明GalT Ⅰ是SGT的一个相互作用蛋白，Ets转录因子家族的成员EIAF可调控其基因的转录。

Two gene fragments of DEN-1(GenBank accession number DQ886390)and DEN-2(GenBank accession number DQ886391),differentially expressed between the ocular skin tissues of normal and albino turbot,were isolated by mRNA differential display and sequenced.It was confirmed by RT-PCR method that the expression levels of both DEN-1 and DEN-2 were down-regulated in the ocular skin tissue of albino turbot.The sequence homology search of DEN-1 revealed high sequence homologies with the UGGT genes of zebrafish and cattle,and the Ugcgl1 gene of Norway rat.High sequence homologies of DEN-2 were observed with the eya4 gene(the eye absent homolog 4)from red jungle fowl,zebrafish,human,Norway rat,mouse and dog.

应用mRNA差异显示技术，对比研究正常与白化大菱鲆有眼侧皮肤组织，克隆差异表达基因，经测序，RT-PCR 验证，差异表达基因片段DEN-1(GenBank登录号：DQ886390)与DEN-2(GenBank登录号：DQ886391)均在白化大菱鲆有眼侧皮肤组织中下调表达；通过BLAST检索发现，DEN-1与GenBank中的斑马鱼和牛的类似尿苷二磷酸-葡萄糖：糖蛋白葡糖基转移酶基因、与挪威鼠类似尿苷二磷酸-葡萄糖：神经酰氨葡糖基转移酶1(Ugcgl1)基因有较高同源性；DEN-2 与原鸡、斑马鱼、人、挪威鼠、家鼠和狗的眼缺乏同源框4(eya4)基因的同源性均较高。

Methods Acute liver impairment models were made by intraperitoneal injecting 0.1 % CCl4(10 mL/kg).AST and ALT were used as indexes to observe liver protection effect of alcohol extract South Wuweizi steamed with vinegar comparing with raw Wuweizi.

方法腹腔注射0.1%的CC l4花生油溶液(10 mL/kg)制作小鼠急性肝损伤模型，以血清中天门冬氨酸氨基转移酶及丙氨酸氨基转移酶为指标，观察比较生品南五味子和醋蒸南五味子乙醇提取物对小鼠肝脏的保护作用。

Coil O85 antigen contained 8 varieties of genes, including UDP-Nacetylglucosamine-2-epimerase gene (f1). UDP-galactopyranose mutase gene, glycosyl transferase genes (f3, f5, f6, f8), O-antigen transferase gene and O-antigen polymerase gene, in which two genes, wzx and wzy and 4 pairs of primers were identified to be specific to E.

发现8个开放阅读框架并确定功能，分别为：UDP-N-乙酰葡萄糖－2-异构酶基因，吡喃型UDP-半乳糖变位酶基因，糖基转移酶基因（orf3、orf5、orf6和orf8），O-抗原转运酶基因和O-抗原聚合酶基因。

Phosphoglycerate kinase 1, fumarate hydratase and aldolase A were expressed in primary cancer.

精氨酸酶，谷胱甘肽S-转移酶A3在肝转移灶中表达上调。

The current study is to test the potential of human secretor type α(1, 2) fucosyltransferase Se α(1, 2) FT］and antisense RNA transcripts complementary to the pig α(1, 3) galactosyltransferase

本文采用5型人腺病毒载体表达了人分泌型α（1，2）岩藻糖基转移酶基因和猪α（1，3）半乳糖基转移酶反义RNA，在体外用高度表达Gal α（1，3）Gal的小鼠NIH3T3细胞，体内用大鼠心脏作为模型检测了它们的表达对Gal α（1，3）Gal生成的影响。

MethodsAfter acate liver injury model was induced by carbon tetrachloride (CCl4), mice were administrated intragastrically with Hypericum japonicum.The serum ALT, AST, SOD, NO, TNF-α, IL-6 were determined and pathological change of liver was observed.

方法以四氯化碳（CCl4）制备小鼠急性肝损伤的模型，田基黄水煎剂灌胃，检测小鼠血清中的丙氨酸氨基转移酶、天冬氨酸氨基转移酶、超氧化物歧化酶活力以及一氧化氮、肿瘤坏死因子-α、白介素-6的含量，观察肝组织的病理损伤程度。

Similar to S-adenosylmethionine decarboxylase(B26),S-adenosylmethionine methyl-transferase(B70), allene oxide synthase(B38),ethylene receptor(B96),cytochrome P450(B58) and methionine synthase (B77) were found in ovaries of Pingyi Tiancha at 1d before the blossom day,which related to plant hormone and could participate in metabolic pathways of ethylene,polyamine,jasmonate acid and gibberellin,et al.,as well as had close relationship with maturity and senescence of plants.

在平邑甜茶开花前1d的子房中发现的S-腺苷甲硫氨酸脱羧酶(B26)、S-腺苷甲硫氨酸甲基转移酶(B70)、丙二烯氧化合酶(B38)、乙烯受体(B96)、细胞色素P450酶(B58)、甲硫氨酸合酶(B77)等相似基因片段与植物体内的生长素有关，将会参与乙烯、多胺、茉莉酸、赤霉素等的代谢途径，与植物的成熟和衰老具有密切的关系。

AIM: To determine the distribution and frequency of functionally important allelic variants in the cytochromes P450 2C19, arylamine N-acetyltransferase 2 (NAT2), and thiopurine S-methyltransferase genes in the Han Chinese population and compare them with those of other ethnic populations.

目的： 了解细胞色素P450(cytochromes P450，CYP)2C19，N-乙酰基转移酶2(arylamine N-acetyltransferase 2，NAT2)和硫嘌呤甲基转移酶(thiopurine S-methyltransferase，TPMT)基因常见的遗传多态性在河南地区汉族人群中的分布及其频率。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。