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The transfer behavior of pyrazolone derivatives, such as antipyrine, aminopyrine, 4-aminoantipyrine and analgin, across the W/NB interface was investigated. The three medicines studied can form complex with a proton and the complex formed can transfer reversely across the W/NB interface and the transfer process was controlled by diffusion. The transfer of protonated analgin was not observed within potential window because of its high transfer potential.

研究了吡唑啉酮类的安替比林、氨基比林、4-氨基安替比林和安乃近四种药物在W/NB界面的转移行为,前三种药物在一定pH值的水溶液中结合一个质子形成1∶1质子配合物,并能在W/NB界面发生可逆转移,其转移过程受扩散控制,安乃近的质子化物由于有较高的转移电位而未在电位窗内观察到其转移峰。

The advantage of supercritical carbon dioxide used as an environmental medium in polymerization and reactions in supercritical carbon dioxide are described. It includes homogeneous free radical polymerizations, precipitation free radical polymerizations, dispersion free radical polymerizations, emulsion and inverse emulsion free radical polymerizations, cationic polymerizations, ring-opening polymerization, melt-phase condensation polymerizations, sol-gel polymerizations, polymer blend synthesis, catalytic chain transfer polymerizations, oxidative coupling polymerization, nitroxide-mediated radical dispersion, atom-transfer radical polymerization, reversible addition-fragmentation chain transfer polymerization, electrochemical polymerization, simultaneous one-pot combination of enzymatic and chemical polymerization, copolymerization of carbon dioxide used as monomer.

评述了ScCO2作为聚合反应介质的优点,以及在ScCO2中可进行的聚合反应类型,包括均相聚合、沉淀聚合、分散聚合、乳液及反相乳液聚合、阳离子聚合、开环聚合、熔融态缩聚、溶液-凝胶聚合、聚合物混合合成、链催化转移聚合、氧化-偶合反应聚合、氮氧自由基可控活性聚合、原子转移自由基聚合、可逆加成-断裂链转移、电化学聚合、原子转移聚合与酶催化开环聚合两种活性聚合在ScCO2中同时聚合、二氧化碳作为原料共聚合等。

Methods The specimens of 50 gastric carcinoma, 22 heteromorphism hyperplastic tissue and 20 normal gastric mucosa were studied with co...

Runx3的表达水平与胃癌的分化程度、淋巴结转移、远处转移有关,Runx3的表达水平在胃癌高分化组、无淋巴结转移组和无远隔转移组明显高于低分化组、有淋巴结转移组。。。

The expression rates of CD44V5+ CD44V6+, cerbB-2+ cells in patients with metastasis, multi-metastasis nodes, DNA heteroploid, SPF elevated, and Apo decreased were higher than those of patients with non-metastasis, only one-metastasis node, DNA diploid, SPF non-elevation and Apo non-decreasing, respectively (P.01 or 0.05), while nm23+, DCC23+ and p16+ were contrary.

肿瘤转移者、多器官转移者、DNA异倍体者、SPF增高者、APO不减低者的CD44V5+、CD44V6+、cerbB-2+细胞表达率均显著高于未转移者、单器官转移者、DNA二倍体者、SPF不增高者、APO不减低者(P.01或0.05)。而nm23+、DCC+、p16+细胞的表达率与此相反。

Cuspidate with 33% identity and 50% similarity to taxadien-5α-ol-O-acetyltransferase, 34% identity and 52% similarity to 10-deacetylbaceatin Ⅲ-10-O-acetyltransferase, and 33% identity and 49% similarity to taxane 2α-O-benzoyltransferase, respectively, moreover, it contained the conserved HXXXDG motif that is found in other transacylases, this sequence element has been suggested to function in acyl group transfer from acyl CoA to the substrate alcohol.

No.AF448807)在氨基酸水平与大部分植物来源的酰基转移酶具有较大的同源性,其中与东北红豆杉紫杉二烯-5α-醇-乙酰转移酶的一致性达33%、相似性达50%,与东北红豆杉紫杉10-去乙酰巴卡亭Ⅲ-10-0-乙酰转移酶的一致性达34%、相似性达52%,与东北红豆杉紫杉二烯2α-0-苯甲酰转移酶的一致性达33%、相似性达49%,并且在TS4的氨基酸序列中还发现酰基转移酶家族成员特有保守序列HXXXDG,这个序列单元被认为在将酰基CoA转移至醇类底物的过程中发挥作用。

The percentage of TGF-β〓 positive cell in the pancreatic cancer tissue (43.8±5.2)% was significantly higher than that in adjacent pancreatic tissue (28.7±3.6)%, P<0.05. The worse the cancer cells differentiated and lymphy node metastasis, the more over-expression of TGF-β〓. 2. The percentage of Tr positive cell in the pancreatic cancer tissue (41±4)% was significantly higher than that in adjacent pancreatic tissue (23±3)%, P<0.05. The worse the cancer cells differentiated and lymphy node metastasis, the more over-expression of Tr, but the expression of Tr protein was not correlated with lymphy node metastasis (P>0.05). 3. The percentage of β-GCD positive cell in the pancreatic cancer tissue (62.5± 4.1)% was significantly higher than that in adjacent pancreatic tissue (33.5±2.8)%, P<0.05. The worse the cancer cells differentiated and lymphy node metastasis, the more over-expression of β-GCD in pancreatic cancer tissue, but the expression of β-GCD protein was not correlated with lymphy node metastasis. P>0.05. 4. the expression of β-GCD was significantly correlated with TGF-β〓 and Tr in the pancreatic cancer tissue.

结果如下:1、胰腺癌组织TGF-β〓阳性细胞百分率(43.8±5.2)%明显高于癌旁胰腺组织(28.7±3.6)%,P<0.05;且癌细胞分化愈差或有淋巴结转移TGF-β〓过度表达愈多。2、胰腺癌组织Tr阳性细胞百分率(41±4)%,明显高于癌旁胰腺组织(23±3)%,P<0.05;且不同分化程度胰腺癌组织Tr表达强度不同,分化程度愈低,表达强度愈高,P<0.05;但胰腺癌Tr表达强度与淋巴结是否转移无关,P>0.05.3、对于胰腺癌组织TGF-β〓和Tr表达,检测胰腺癌组织(32例)β-GCD阳性细胞百分率分别为(62.5±4.1)%或(62±4)%,分别明显高于癌旁胰腺组织β-GCD阳性细胞百分率(33.5±2.8)%或(43±3)%,P<0.05;不同分化程度胰腺癌组织β-GCD表达强度不同,分化程度越低,表达强度越高,P<0.05;但胰腺癌组织β-GCD表达强度与淋巴结是否转移无关,P>0.05.4、TGF-β〓、Tr和β-GCD在胰腺癌组织中的表达随着分化程度的改变,呈现一致性的关系,而且TGF-β〓与淋巴结转移有关,Tr和β-GCD与淋巴结是否转移无关。

The expression of MMP-2 was higher while oncosis index was lower in the cases with lymph node metastasis than those without.

MMP-2在淋巴结转移组的阳性表达率为69.57%(16/23),明显高于无淋巴结转移组的42.86%(12/28);有淋巴结转移组胀亡指数明显低于无淋巴结转移组P.05)。

Hca-P and Hca-F is a pair of syngenetic mouse hepatocarcinoma ascites cell lines, presenting a specific potential of lymphatic metastasis when inoculated subcutaneously in 615 mice.

Hca-F细胞和Hca-P细胞分别为高淋巴结转移和低淋巴道转移细胞株,在615小鼠内淋巴结转移率分别大于70%和小于30%,是研究癌症淋巴道转移机制难得的细胞株模型。

The lower neck node area and supraclavicular fossae were irradiated with the conventional technique by anterior field. results with a median follow up of 12 months(range 2~32 months), 6 patients died(4 died of distant metastasis), 5 patients relapse in the primary site, 2 patients relapse in the neck and 16 patients showed distant metastasis.

结果 中位随访时间12个月(2~32个月)。6例死亡(其中4例死于远处转移),5例原发灶复发,2例颈部复发,16例远处转移。1年和2年的总体生存率、无局部复发生存率、无区域进展生存率和无远处转移生存率分别为100%,94.6%;98.4%,91.4%;99.1%,97.9%及91.9%,85%。n分期是影响无远处转移生存率的预后因素(p=0.04)。

Because the rate of ET and HT reactions is determined by the coupling term J, and in long range ET and HT systems the degeneracy of the π orbitals of donor and acceptor is lifted through mixing with the bridge orbitals of appropriate symmetry by an amount △E. Because the △E splittings are proportional to electronic coupling, so we can use the static quantity △E to exploring the dynamic quantity J, and to make a detailed study on the microscopic influence of coupling mechanism in ET and HT process.

由于电子转移和空穴转移反应速率的大小决定于反应的耦合因子,在长程电子转移和空穴转移体系中,给体和受体的简并π轨道由于与饱和桥之间的TB作用而产生一定的分裂能,此分裂能又与耦合因子的数值成正比,因此,我们可以用静态的分裂能数值间接地表征动态的耦合因子,从而详细研究电子转移和空穴转移过程中耦合机理的微观影响因素。

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