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Then sold out the factory, and finally transferred to the hands of a few shareholders, of which the holder is the most important Gonzalo ...

后又将工厂转卖出去,最后转到了几位股东手上,其中最主要的持有人是Gonzalo 。。。

The transforming growth factor-β superfamily, a large group of highly conserved growth factors including TGF-βs, activins and BMPs, regulate a wide variety of cellular functions such as proliferation, differentiation, apoptosis and migration. Signals from these growth factors are transduced by a group of Smad proteins. To date, there are nine vertebrate Smads, including the receptor-activated Smads , Smadsl-3, 5 and 8, the common mediator Smad4 and Smad4β, and the inhibitory Smads, Smad6 and 7. Signaling is initiated when the ligand induces assembly of a heteromeric complex of type Ⅱ and type Ⅰ TGFβ receptors. Then R-Smads are directly phosphorylated by activated type I TGF-β receptors.

在多种SMADS中,SMAD5令我们产生兴趣,基于三个原因:1、Smad5基因敲除胚胎中发现卵黄囊的异位造血以及CFU-GM祖细胞数目增加,表明SMAD5可能是早期造血发育的负向调控基因。;2、应用反义核酸封闭Smad5可以逆转TGF-β对祖细胞增殖的抑制效应,表明它可能介导TGF-β信号转导,后者的异常,包括某些SMADS的功能异常,和白血病紧密相关;3、Smad5基因定位在人染色体5q21,此区域的缺失和急性髓系白血病和骨髓增生异常综合症相关,因此,Smad5被怀疑为白血病抑制基因。

We chose 30 type milli-needle as tools after routine sterilization. Usually we pick levelly 0.5-0.8 inch at Baihui, 1. 5 inch at Jiaji, 1-1. 5 inch inclinedly to the nose tip at Fengchi, 1-1. 5 inch inclined at Jianjin, 1-1. 5 inch at Shousanli. After obtaining gas by rotating method, we used moxibustion at Baihui by lighting the moxa strip, and put the acupuncture and moxibustion therapeutic instrument (made in shanghai, G6805-Ⅰ) at other acupuncture points. We chose thin and dense wave and adjust the current strength according to endurance of the patients, and 20 minutes each time, one time every other day, 15 times a course.

操作:患者俯卧位或坐位,选30号毫针,常规消毒,管筒进针,进针后百会穴平刺0.5~0.8寸,夹脊穴直刺1.5寸,风池穴针尖微下,向鼻尖斜刺1~1.5寸,肩井斜刺1~1.5寸,手三里直刺1~1.5寸,行捻转法得气后,将艾条点燃后于百会穴上行温和灸,其余各穴接上海产G6805-Ⅰ型针灸治疗仪,用疏密波,电流强度以病人能耐受为度(其中风池穴的电流强度以偏小为宜),每次20分钟。

Micrococcal lysis assay of the milk samples showed that the cDNA was efficiently expressed in the mammary glands with similar expression levels ranging from 60 to 87 mg/L. Different tissues of each vector-injected mouse were assayed for transcription of hLYZ mRNA by dot-blotting and for expression of hLYZ activity by Micrococcal lysis assay. The results showed that expression of the three recombinant vectors was mainly restricted to mammary glands with some degrees of ectopic expression in spleen, intestines and/or kidney.

注射后72 h采集乳样,经微球菌溶解实验证明,3组小鼠乳汁中hLYZ的表达量分别为87、69、60 mg/L;从每组小鼠的12种组织提取总RNA,经Dot blotting检测证明,三种重组载体除在乳腺中表达外,p205C3LYZ还在小鼠的脾和肠、pBJLYZ在脾、pBCLYZ在脾和肾中具有一定的异位表达;在有hLYZ mRNA转录的上述脏器中用微球菌溶解试验均可检测到hLYZ活性。

He saw the moonlike phases of Venus, indicating that this planet circled the sun, not the Earth, in even greater disobedience of the priests.

他看见金星如月亮般的位相,表明金星围绕太阳而转,并不是地球,这与神父讲的更加南辕北辙。

Species richness of phytophagous insects in plantation of transgenic insect-resistance hybrid poplar 741 was obviously lower than that of neutral arthropod. The individuals of intermediate and top species apparently increased.

转双抗虫基因741杨(简称转基因741杨)节肢动物群落中,基位物种的植食性昆虫丰富度显著降低,但中性节肢动物丰富度却明显增加。

Then, cl-I, an allele of cl, was also isolated from maize. It was thought to act as a transcriptional represser in the anthocyanin pathway.

后来人们又发现了c1的等位突变基因c1-I,它在相应基因转录方面的调节作用与c1相反:抑制花青素的合成。

The screening method of seven alleles (Z-6,Z-4,Z -2,Z,Z+2,Z+4 and Z+6) in then dinucleotide tandem repeat sequence was st udied. These alleles constitute a microsatellite DNA marker upstream of the tran scription initiation site on the aldose reductase gene.

湖南医科大学学报000103 摘要:研究了醛糖还原酶基因转录起始点上游-2.1kb处的微卫星DNA标记--n二核苷酸串联重复序列7种等位基因(Z+6,Z+4,Z+2,Z,Z-2,Z-4和Z-6)的筛选方法。

The screening method of seven alleles (Z-6,Z-4,Z -2,Z,Z+2,Z+4 and Z+6) in then dinucleotide tandem repeat sequence was st udied. These alleles constitute a microsatellite DNA marker upstream of the tran scription initiation site on the aldose reductase gene.

研究了醛糖还原酶基因转录起始点上游-2.1kb处的微卫星DNA标记--n二核苷酸串联重复序列7种等位基因(Z+6,Z+4,Z+2,Z,Z-2,Z-4和Z-6)的筛选方法。

Those voters will be redirected 2.5 miles away to the Snoqualmie Fire Station located at 37600 SE Snoqualmie Parkway.

这些选民将会被转至2.5里外,位於37600 东南 Snolqualmie Parkway 的史诺夸米消防站。

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With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务,乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐,因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。

Closes the eye, the deep breathing, all no longer are the dreams as if......

关闭眼睛,深呼吸,一切不再是梦想,犹如。。。。。。