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It encodes a putative zinc finger transcription factor, and is a transcriptional corepressor for thyroid hormone receptors. Hairless gene plays a critical role in maintaining the delicate balance between cell proliferation, differentiation, and apoptosis in the hair follicle as well as in the interfollicular epidermis, and is concerned with the control of hair growth cycling.

无毛基因是与皮肤和被毛结构有重要关联的核受体基因，编码一个锌指结构转录因子，是甲状腺激素受体的转录辅阻遏物，并参与毛发生长周期的调控，在维持毛囊及毛囊间上皮的增殖、分化、调亡的精致平衡中扮演重要角色。

Methods: After transferred pcDNA3.1/hTM plasmid into rabbit artery by high-pressure injection, rabbit common iliac artery were cut and anastomosed again. At the 14 days and 28days after second operation, we checked inside diameter of anastomotic stoma and blood flow velocity by color Doppler. The treated artery were sliced and stained by Verhoeff. Local neointima formation and the ratio stenosis of intervascular were calculated by computer.

用注射式加压转染的方式对兔动脉壁转染pcDNA3.1/hTM质粒，再制造动脉损伤-阻滞模型，于术后14天、28天用彩色多普勒观察活体吻合口内径和血流流速；再做病理切片Verhoeff染色，观察血管内膜增生的程度、部位，计算血管内膜面积、中膜面积和血管狭窄率。

CaN Aβ gene silencing can reduce myocardial hypertrophy in cultured cells, si1280 (21bp) of CaN Aβ gene is the most effective target site for siRNA. The method of intrapericardial injection of plasmid, microbubbles and erzymes can improve transfection efficiency of non-viral plasmid with satisfying targeted transfection. But the scope of transfected myocytes is still limited. CaN Aβ shRNA expressing plasmid transfection in vivo by pericardial injection results in decreased CaN Aβ protein expression of small part of myocytes, and CaN Aβ mRNA only shows decreased trend. The dosage of non-viral vector and the parameters of ultrasound energy should be optimized in further study.

结论RNAi技术抑制CaN Aβ基因表达可有效减轻Ald诱导的心肌细胞肥大程度；CaN Aβ基因中si1280(21bp)片段为实现RNAi的更有效片段；微泡+酶类心包腔内注射超声导入的方法可有效改善非病毒载体在体心肌的转染效率，同时具有一定的靶向性，但总的转染范围仍然有限；采用这一方法进一步进行&一肾一夹&心肌肥大模型大鼠在体心肌细胞的CaNAβ的RNAi干预，发现心肌肥大大鼠心外膜下局部心肌细胞CaN Aβ蛋白水平降低，CaN AβmRNA水平虽有下降趋势，但无统计学差异，提示质粒的用量及超声导入的参数有待进一步研究使其优化。

Immunofluorescence staining shows that, the CaN Aβ protein expression of intrapericardial injection group decreased in some myocytes under epicardium, while other groups show no decreased fluorescence.

三在体心肌CaN AβsiRNA表达质粒转染后，转染各组与心肌肥大模型组CaN AβmRNA水平比较无差异(P＞0.05)，但免疫荧光结果显示心包腔内途径CaN Aβ干扰组较心肌肥大模型组心外膜下部分心肌荧光减弱。

Objectives To study the expressions of STAT1 and PDGF in lung tissue of pulmonary fibrosis model induced by bleomycin in rats, and discuss the possible mechanism.Methods Thirty Wistar rats were randomly divided into two groups (15 in each group), they were bleomycin group and control group.①The BLM group was intratracheally instilled with belomycin (5mg/kg);② NS group was intratracheally instilled with saline (5mg/kg).

目的 观察肺纤维化鼠肺组织信号转导和转录活化因子1（STAT1）和血小板源性生长因子表达的变化，探讨其在肺纤维化的作用机制方法 30只Wistar大鼠随机分博莱霉素组和对照组，①BLM组：气管内灌注BLM（5mg/kg）诱导肺纤维化；②NS组：气管内灌注NS。

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在英译汉过程中，有些句子可以逐词对译，有些句子则由于英汉两种语言的表达方式不同，就不能逐词对译，只能将词类进行转译之后，方可使译文显得通顺、自然；对词类转译技巧的运用须从四个方面加以注意。

The proliferation of SGC-7901 cell line was markedly inhibited by shRNA-GC-CⅢ（ P .05）. There was changes in cell morphology, such as cell volume reduction, karyopyknosis and chromatin conglomeration. FCM showed that GC-C inhibition caused the appearance of sub-G 0 /G 1 peak which increased from 5.47%（48h after transfection） to 5.63%（72h after transfection）.

转染GC-C shRNA真核表达载体后SGC-7901细胞的增殖能力受到抑制（ P 。05）；细胞形态发生改变，细胞体积缩小，核固缩，染色质浓缩聚集于核膜；流式细胞术检测显示G 1 峰前出现亚二倍体峰，转染48、72h后凋亡率分别为5.47%和5.63%（ P nbsp； 0.05）。

Cells were transfected with lamin A/C siRNA using the transfection reagents indicated, according to the manufacturer's protocol.

RNAiFect 是一种基于脂质的转染试剂，专门用于 siRNA 转染，确保没有 RNAse 活性。

Exogenous lignoceric acid (C24:0) showed a similar effect on protein accumulation and gene activation, indicating that these two compounds may indeed promote fiber elongation by sequentially modulating the production of specific cell wall polymers.

乙烯和C24：0处理的蛋白质组学和转绿水平分析表明：乙烯和24碳饱和脂肪酸(C24：0)能诱导UER1、UGD1和UGP1的蛋白和转录水平的显著提高。暗示二者能够通过诱导某些特殊细胞壁多糖的合成，从而导致纤维细胞的伸长。

The result showed that Insulin capsule could increase the insulin sensitivity of model rat of insulin resistance of typeⅡdiabetes mellitus by decreasing its blood sugar,decreasing its avoirdupois,improving its lipodystrophy and hemodynamics , increasing its GLUT4 translocation of skeletal muscle cell,increasing expression level of GK in liver cell, increasing expression level of PEPCK and decreasing level of TNF-αexpression in adipose tissue.

结果表明，胰苏灵胶囊可使2型糖尿病IR模型大鼠的血糖降低、体重减轻、脂质代谢异常得到改善、血流变异常得到改善；能使模型大鼠的脂肪组织TNF- a的mRNA表达水平降低，能使模型大鼠骨骼肌细胞的GLUT4的转位增加，能增加肝GK表达，能诱导PEPCK的转录。通过以上作用，胰苏灵胶囊可使2型糖尿病IR大鼠模型的IR得到改善。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。