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Methylation is negative correlation with genetic transcription , and the mechanism is probably as follows : directly interfere the combination of specific transcripton and recognition site of each promoter ; mediated transcription inhibition by change the construction of chromatin; induced gene silencing by combination of methylation site and transcription inhibition. P16 gene is also called multiple tumor supresser gene , which is the best easily to methylate in the anti-oncogenes. P16 gene locates in 9p21 of mankind-chromatosome , and it's total length is 8.5kb .

甲基化与基因转录呈负相关，其机制可能是[3]：直接干扰特异的转录子和各自启动子识别位点的结合；通过改变染色质结构，介导转录抑制；甲基化DNA位点直接与转录抑制子结合，诱导基因沉默。p16基因又称为多肿瘤抑制基因( multiple tumor suppressor 1 ，MTS1) [4] ，是肺癌中最易发生甲基化的抑癌基因，该基因位于人类染色体9p21上，全长8.5kb ，由两个内含子和三个外显子组成。

For I feel peaceful and comfortable nearside Zhuanjing Lun,without them ,emptiness around me .

没有转经轮我会觉得心空荡荡的，我对转经轮很有信心，只要我有生之年有一口气，我就要弘扬转经轮，只要有客人来，我就赠送转经轮作为礼物，种下善根。

In view of special applications of multi-pole magnetic permanent torque motor used for precise numerical control rotary table, motors with higher torque density and lower torque ripple s are needed.

针对精密数控转台伺服直接驱动用多极永磁力矩电机的特殊应用问题(要求电机有较大的转矩密度且较小的转矩波动)，在分析该种电机的特殊结构的基础上，提出一种新型不等齿顶宽结构，以提高绕组利用系数，加大电机的转矩密度；并采用转子斜极的方法，可在有效消除转矩波动的同时，电机仍保持较高的绕组利用系数。

In view of special applications of multi-pole magnetic permanent torque motor used for precise numerical control rotary table, motors with higher torque density and lower torque ripples are needed.

针对精密数控转台伺服直接驱动用多极永磁力矩电机的特殊应用问题(要求电机有较大的转矩密度且较小的转矩波动)，在分析该种电机的特殊结构的基础上，提出一种新型不等齿顶宽结构，以提高绕组利用系数，加大电机的转矩密度；并采用转子斜极的方法，可在有效消除转矩波动的同时，电机仍保持较高的绕组利用系数。

The scale analysis on planetary scale motion in the tropical atmosphere shows that the equilibrium between the pressure gradient force and Coriolis force in the meridional direction is easily established, which is known as the zonally semi-geostrophic motion The semi-geostrophic adaptation process in which the inertial gravity waves play an important part is relatively quick The evolution process after the semi-geostrophic adaptation process is slow and controlled by the Kelvin waves and long Rossby waves

对热带大气行星尺度运动所做的尺度分析和物理分析表明：热带大气的行星尺度运动在y方向容易实现气压梯度力与Coriolis力的平衡，它称为纬圈的半地转运动。半地转平衡的建立过程，也就是半地转适应过程相对是很短暂的，它不需要考虑f=β0y随y的变化，因而主要依靠惯性重力波为频散；而半地转平衡建立后的演变过程相对是很缓慢的，它主要受Kelvin波和Rossby波控制。

Moreover,through the review of relevant literature on CIT,we find that there are still some aspects left uncovered or seldom covered. These aspects are as follows:(1)for the issue of the role of metonymy in conceptual integration,and the aspects of the role of metonymy in satisfying optimality principle;(2)the applications of metonymy in English and Chinese idiomatic expressions,especially in the two special kinds of Chinese idioms—set phrases and wisecracks.

通过对相关文献的回顾，我们发现还有一些方面论述较少或没有论述到，这些方面如下：(1)关于转喻在概念整合中的作用，以及转喻在满足概念整合的优化原则中的作用；(2)转喻在英语和汉语熟语中的应用，尤其是汉语熟语中所特有的两种形式，即成语和歇后语等转喻性和隐喻性表达在概念整合网络中的在线意义构建和幕后认知。

Direct torque control is another high performance control technique of AC motor, it discard the decouple idea of vector control, but adapt flux oriented control and transient space vector theory, directly control stator flux and torque, it has the advantage of rapid torque response and less relying on stator parameters, but has the disadvantage of bigger torque ripple.

直接转矩控制技术是继矢量控制技术之后的又一种交流电机高性能控制技术，它摈弃了矢量控制中解耦的控制思想，采用定子磁链定向和瞬时空间矢量理论，直接对电机定子磁链和转矩进行控制，具有转矩响应快、对电机参数依赖小的优点，但它的不足之处就是存在转矩脉动。

Methods In this study,a plasmid vector,rAd5,and rAAV2 were used to transfect rat cochlear marginal cells of stria vascularis by injection into the perilymph through the round window membrane,and the transfection efficiency, target tissue accessibility, cell/ tissue toxicity, time course of expression, and effect on hearing were evaluated in vivo and in vitro.

结果三种载体对原代培养的大鼠耳边缘细胞的转染研究发现，腺病毒的转染效率最高，而腺相关病毒转染对细胞活性影响最小。rAAV2和rAd5对大鼠耳蜗组织的感染实验发现，腺病毒和腺相关病毒携带的增强型绿色荧光蛋白可在多种耳蜗组织中及转染对侧耳蜗组织表达，且并不引起明显的耳蜗组织细胞凋亡。rAAV2携带的EGFP基因在第90天时仍可检测到大量表达。rAd5携带的EGFP基因在第30天时表达明显减弱。

PIAS proteins play roles mainly through two mechanisms: acting as SUMO E3 ligases to promote modifications of some transcriptional factors and cofactors, especially sumoylation, and to regulate their transcriptional activation; acting as structural proteins to offer platforms for protein-protein interactions and to promote the abstraction and recruitment of other regulators in the cellular signal pathway complexes or gene transcriptional complexes, companied by the subnuclear location of target proteins.

PIAS蛋白的调控机制主要有两种：一种是通过其自身所具有的SUMO(small ubiquitin-related modifiers)E3连接酶活性，促进对一些转录因子、转录辅因子的化学修饰，尤其是SUMO化修饰，从而调控它们的转录活性；另一种是作为构架蛋白，为蛋白质之间的相互作用提供平台，促进细胞信号通路复合物或基因转录复合物中其它调节蛋白的去除和募集，并涉及到靶蛋白的亚核定位。

Put the operating objects into water for soaking absolutely, then enforce the picture surface to be face to face with the object surface after printing film separates from floor sheet absolutely and finally fish out the object after verifying the position of printing film, which is more suitable to print round object with a large-scale or curly surface.

将欲转印的物品完全泡在水中，待转印膜与底纸完全分离后，将转印膜图像面向上置于物品表面，调整好转印膜的位置，再从水中小心将物品捞出。（此方法适合大幅面和曲面转印）。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。