起皱

As exposed to optics microscope and inverted microscope,compared to control,SW480 cells with Giemsa staining that treated with the H2RA(cimetidine、nizatidine) took on malignance declining as crimpled firstly,cellular bulk and heteromorphism dimimished,the amount of rounded cell manifolded,nucleolus bulk lessened,dyeing thin,the amount of nucleolus decreased,partial cell organs manifest side-gathering phenomenon on chromatin,and the link between SW480 cell is loosened , subsequently partial rounded cell is floated.When the H2RA(cimetidine 40μM、nizatidine 20μM) against SW480 cells after 3 day,SW480 cells change roundly,nucleolus smashed,shrinking nucleolus came into being,and part of those not adhibited cell wall.

在光镜和倒置相差显微镜下，与对照组相比，经姬姆萨染色观察，西咪替丁、尼扎替丁处理的SW480细胞，先发生皱缩，体积变小，异形性减少，细胞变圆数目增多，细胞核变小，染色变淡，核仁数量减少，部分可见染色质边集现象；细胞间连接疏松，随后部分变圆细胞浮起。40μM西咪替丁及20μM尼扎替丁连续处理3天后，SW480细胞全部变圆，细胞核碎裂，固缩微核形成，部分不再贴壁。

"Jess?" My nose wrinkled as I cringed, waiting for her to turn on me.

&杰西？&虚弱的声音一出我便皱起鼻子，等着她转身看我。

Her forehead crinkled almost as if it hurt to speak.

她的额头皱起好象它被要说的话刺痛。

His eyes were bright blue, crinkled up into a permanent squint like a sailor's from gazing into the far distance.

他的眼睛是蓝的，常常会象水手那样皱着眉头，眯起眼睛注视远方。

"Oh, that's good, that is," she said, then gifted Simon with a dazzling smile, eyes crinkling at the corners.

&哦，很好吃。&她说，皱起眼角，对Simon笑了一下，这笑容象是送给Simon的礼物，使他眼花缭乱。

That wide mouth tilting. The corners of his eyes crinkling. The deep cleft in his cheek he refused to call a dimple.

我可以想像出他的笑容宽宽的嘴巴歪着，眼角皱起，脸颊上露出他拒绝称作酒窝的凹陷&那么你还记得我？&

To help your baby's small-motor skills, play lots of games that involve picking up objects, organizing them, stacking, nesting, pouring, tearing, crinkling, and crushing.

为了帮助婴儿提高他们小肌肉群的运动技能，应多玩一些与此有关的游戏，比如捡起物品、摆放、堆积、叠放、倾倒、撕扯、弄皱，和打碎。

To help your baby's small-motor skills, play lots of games that involve picking up objects, organizing them, stacking, nesting, pouring, tearing, crinkling, and crushing.

帮助孩子提高轻微肌肉运动技巧，玩大量的游戏，包括捡起物品、摆放、堆积、叠放、倾倒、撕扯、弄皱，和打碎。

He frowned."What I meant to say was, don't do what you're doing."

他皱起眉。&我的意思是说，不要做你正在做的事。&

"No, not really," he said. He frowned.

&不，真不是&，他皱起了眉头。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。