赋形剂

The present invention relates to immunogenic compositions for intradermal delivery of an antigenic or immunogenic agent in combination with one or more excipients.

本发明涉及免疫原性组合物，其用于皮内输送与一种或多种赋形剂相组合的抗原性或免疫原性试剂。

Methods: According to the refe-rence of new traditional Chinese medicine study, maximal dosage of drug was given to rabbits to do the acute toxicological and irritative test on skin. The guinea pig was used to do the skin hypersensitive test with excipient as negative control and 1% 2,4-dinitrochlorobenzene as the positive control.

参照中药新药研究指导原则，采用最大给药剂量法对大白兔进行皮肤用药急性毒性和刺激性试验；以赋形剂为阴性对照，1%的2，4-二硝基氯苯丙酮溶液为阳性对照，对豚鼠进行皮肤过敏性试验。

Bulk substances (e.g., drug substances, impurities, excipients) should be stored in opaque nonreactive containers.

而像原料药，杂质，赋形剂等，则应当要保存在不透明的惰性容器中。

Objective To assess the results of lacrimal duct probing followed by irrigation with ofloxacin based on methylcellulose in infants under1years old with epiphora,due to congenital nasclacrimal duct obstruction.Methods Following the failure of regular lacrimal sac massage,60infants（67eyes）under1years old with persistent epiphora and impeded lacrimal drainage systemwere performed lacrimal duct probing followed by irrigaˉtion with ofloxacin based on methylcellulose under topic anesthesia.

目的 评价对患先天性鼻泪管阻塞的1岁内婴儿施行泪道探通术联合泪道内灌注氧氟沙星眼膏的临床效果方法因持续性泪溢、泪道冲洗不通，经泪囊区局部按摩无效而被确诊先天性鼻泪管阻塞的1岁内婴儿60例（67眼），在局麻下施行泪道探通术，并注入泪道以甲基纤维素为赋形剂的氧氟沙星眼膏，术后点滴氧氟沙星眼水1周。

Methods Following the failure of regular lacrimal sac massage,60infants（67eyes）under1years old with persistent epiphora and impeded lacrimal drainage systemwere performed lacrimal duct probing followed by irrigaˉtion with ofloxacin based on methylcellulose under topic anesthesia.

因持续性泪溢、泪道冲洗不通，经泪囊区局部按摩无效而被确诊为先天性鼻泪管阻塞的1岁内婴儿60例（67眼），在局麻下施行泪道探通术，并注入泪道以甲基纤维素为赋形剂的氧氟沙星眼膏，术后点滴氧氟沙星眼水1周。

Intravitreous injection of TA with the dosage of ≤25 mg without excipient does no harm to the retinal configuration and function, and excipient may lead to the change of retinal configuration and function.

我们观察了有无赋形剂的不同剂量TA对视网膜功能和形态的影响，现将结果报道如下。1材料和方法纯种新西兰白兔32只，雌雄不限，兔龄8个月，随机分成4组行右眼

Carbowax of matrical suppository can dissolve in water and various organic solvents, having superior lubricity and thermostability, having no toxicity and stimulation. The electrolysis has no influence on it dissolved in water. As a excipient , it has a protection to the interferon albumen.

本处方系参照《药剂学》中的配方而设计的，栓剂基质聚乙二醇能溶于水和多种有机溶剂，有优越的润滑性及热稳定性，几乎没有毒性和刺激性，对水的溶解性不受电解的影响，用做赋形剂，对干扰素蛋白有保护作用。

METHODS: Thirty-six rabbits underwent perivascular injury at both carotid arteries, followed by a 1.5% cholesterol diet. After 90 days, rabbits were randomly divided into 6 groups and treated 5 times with vehicle or ETC-216 at 5, 10, 20, 40, or 150 mg/kg dose every 4 days.

36只兔子在双侧颈动脉制造外周血管损伤，随机给予1.5%的胆固醇餐。90天后，兔随机分为6组，用赋形剂或ETC-216以5，10，20，40，150 mg/kg 剂量每4天给药1次。

The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA compounds in a pharmaceutically acceptable carrier or excipient.

此处的该组合物含有一种基本上纯的至少一种邻苯二酚丁烷，包括，例如，在一种制药学上可接受的载体或赋形剂中的NDGA化合物的制剂。

The first, selecting Mannitol of polyhydric and Dextran ofpolysaccharide as subsidiary material, In accordance with differentusing quantities, making up eight recipes, freeze-drying test is madewith eight recipes differently. By adjusting recipe, to select themethod of two factors three levels. The best recipe determined is thatof Mannitol(160mg/bottle) and Dextran(40mg/bottle), Solving theproblem of description、moisture(≤1.5%)、solution(≤6s)、stability(95.0～110.0%) etc., The quality of preparation has beenimproved.

首先，选择赋形剂多元醇类的甘露醇和多糖类的右旋糖酐作为辅料，按照不同的用量，组合成8种处方进行冷冻干燥试生产，采用二因素三水平的满因子分析法，通过处方调整，确定甘露醇160mg／瓶、右旋糖酐40mg／瓶为最佳处方，解决了冻干制剂在性状、水分(≤1.5％)、溶解性(≤6s)和含量稳定性(95.0～110.0％)等方面的不足，提高了产品质量。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。