贫血的

Sickle-cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality.

镰状细胞性贫血是最流行的遗传性疾病之一，具有很高的发病率和死亡率。

Sickle-cell anemia is one of the most prealent hereditary disorders with prominent morbidity and mortality.

镰状细胞性贫血是最流行的遗传性疾病之一，具有很高的发病率和死亡率。

Examples of so-called SNP diseases are sickle-cell anemia and Huntington's disease, where a single variant or mutation has a dramatic effect.

镰状细胞性贫血和亨庭顿综合症就是这样的疾病，单个变异起了很大的作用。

We would be saying in effect that we prefer to leave genetic destiny to the crap shooting of nature, despite sickle-cell anemia and Tay-Sachs and all the rest, because ultimately we don't trust the market to regulate life itself.

禁止使用这种技术，等于表示我们宁愿把基因的命运留在大自然的手中，好像掷骰子一样。虽然可能发生镰状细胞贫血症、泰萨氏症等各种各样基因病变也甘冒风险，因为我们骨子里并不放心让市场来调节生命演进。

We would be saying in effect that we prefer to leave genetic destiny to the crap shooting' of nature, despite sickle-cell anemia and Tay-Sachs and all the rest, BEC ause ultimately we don't trust the market to regulate life itself.

禁止使用这种技术，等于表示我们宁愿把基因的命运留在大自然的手中，好像掷骰子一样。虽然可能发生镰状细胞贫血症、泰萨氏症等各种各样基因病变也甘冒风险，因为我们骨子里并不放心让市场来调节生命演进。

Note: pregnancy, lactation, severe liver damage, jaundice, or a continued itching during pregnancy, Dubin-Johnson syndrome, Rotor syndrome, liver cancer or a history of liver tumors, thromboembolic, or a history of sickle-cell anemia, breast cancer or endometrial cancer, vascular changes associated with severe diabetes, lipid metabolism disorders, should be used with caution.

注意事项：妊娠，哺乳，严重的肝功能损害，黄疸或在妊娠期有持续瘙痒，Dubin-Johnson综合征，Rotor综合征，肝脏肿瘤或有肝脏肿瘤病史，血栓栓塞或病史，镰状细胞性贫血，乳腺癌或子宫内膜癌，伴有血管变化的严重糖尿病，脂质代谢紊乱，均应慎用。

With the removal of oxygen from sickle hemoglobin, the red blood cell deforms into a sickled shape. This sickling damages the RBC membrane and increases the likelihood of rupture and anemia.

随着镰珠蛋白中氧的去除，红细胞变形成镰状，红细胞膜受到破坏，破裂的可能性增加，从而导致贫血。

In fact, it is very common for these diseases to be the cause of anemia, so both diseases end up existing side-by-side.

事实上，这是非常常见的为这些疾病的原因是贫血，所以这两种疾病最终现有并存。

An abnormal stippling of red blood cells with basic staining granules.

大红细胞异常增大的红细胞，特指与恶性贫血有关的

This can be the case for genes with a heterozygote advantage, such as sickle cell anemia or Tay-Sachs disease, which in their heterozygote form may offer an advantage against, respectively, malaria and tuberculosis.

有杂合体优势的基因就是这种情况，如镰状细胞贫血或泰-萨克氏症在其杂合子形式可以分别提供抵御疟疾和肺结核的优势。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。